The histologic subtype of ovarian tumors affects the detection rate by pelvic washings

Fadare, Oluwole; Mariappan, Malaiyalam; Wang, Sa; Hileeto, Denise; McAlpine, Jessica N.; Rimm, David L.

doi:10.1002/cncr.20239

Cited by 23 publications

(35 citation statements)

References 80 publications

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“…However, widely varying figures have been reported regarding its sensitivity for peritoneal involvement in ovarian tumors [1]. Also, studies regarding the accuracy of PW cytopathology, as evaluated in comparison with final histopathologic findings, have been strikingly discordant [1]. For example, some studies reported false-negative cytopathology in the presence of disseminated peritoneal disease in a range of 20–85% of cases [12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Since its introduction more than 50 years ago, the PW has gained widespread acceptance and is used routinely at most centers. However, widely varying figures have been reported regarding its sensitivity for peritoneal involvement in ovarian tumors [1]. Also, studies regarding the accuracy of PW cytopathology, as evaluated in comparison with final histopathologic findings, have been strikingly discordant [1].…”

Section: Introductionmentioning

confidence: 99%

“…a 94.6% survival rate for stage I disease confined to the ovary/ovaries vs. a 28.2% survival rate for stage III or IV disease with distant metastasis). Methods of detection of microscopic disease in EOC therefore are of significant interest and may reduce the mortality rate for this disease by enabling an earlier diagnosis of primary and/or recurrent EOC [1]. …”

Section: Introductionmentioning

confidence: 99%

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Significance of Peritoneal Washing Cytopathology in Ovarian Carcinomas and Tumors of Low Malignant Potential: A Quality Control Study with Literature Review

Özkara

2010

Acta Cytologica

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Objective: The author evaluated a consecutive group of peritoneal washings (PWs) performed in the evaluation of adnexal masses to determine whether the conventional histopathologic prognostic parameters significantly affect the tumor detection rate using this procedure. Study Design: Cytopathologic reports from all PWs performed over a 13-year (1996–2008) period in the evaluation of malignant and borderline ovarian tumors were reviewed and correlated with those of the synchronously obtained histopathologic specimens. Tumors of low malignant potential (LMP) were separated for analysis. Statistical significance was determined using the χ² test. Results: In the study, a total of 134 PWs were associated with primary epithelial malignant tumors (n = 114) or tumors of LMP (n = 20) involving the ovary. The positive PW cytopathology rates for clear cell (83.3%), undifferentiated (80.0%), and serous carcinomas (65.7%) were higher than the overall average positive rate (62.3%) for all histopathologic subtypes. In contrast, endometrioid (41.2%) and mucinous (45.5%) carcinomas had markedly lower cytopathology-positive rates than the overall average positive rate (p = 0.118). As expected, PWs were found to be significantly more likely to yield malignant cells in higher-grade (grades II + III, 71.1%, p = 0.002) and higher-stage (stages III + IV) tumors (76.6%, p = 0.000) than in lower-grade (grade I, 38.7%) and lower-stage (stages I + II) tumors (32.4%) and also in tumors with lymph node involvement (72.7%, p = 0.021) than in tumors without lymph node involvement (46.7%) and in bilateral tumors (74.6%, p = 0.004) than in unilateral tumors (42.9%). The positive cytopathology rates for the PWs of the corresponding primary ovarian carcinomas with prominent pleomorphism (81.0%, p = 0.007), with high mitotic score (80.0%, p = 0.006) and solid architecture (72.9%, p = 0.122) were also higher than the overall average positive rate. The overall sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and efficiency for the ovarian carcinoma (n = 114) cases were 72.3, 85, 95.8, 39.5 and 74.6%, respectively. The positive cytopathology rate for the PWs of the serous tumors of LMP (7.1%) was higher than that of the mucinous tumors of LMP (0.0%) and the overall average positive cytopathology rate (5.0%) for the ovarian tumors with LMP. The calculated sensitivity, specificity, PPV, NPV, and efficiency for tumors of LMP were 33.3, 100, 100, 89.5, and 90%, respectively. Conclusion: PW cytopathology results correlate significantly with almost all of the conventional histopathologic prognostic parameters and the cyto-histomorphologic parameters of the corresponding primary ovarian carcinomas. The positive cytopathology rates also differ according to the histopathologic subtypes. False negativity and ‘false positivity?’ was significantly correlated with tumor grade.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Significance of Peritoneal Washing Cytopathology in Ovarian Carcinomas and Tumors of Low Malignant Potential: A Quality Control Study with Literature Review

Özkara

2010

Acta Cytologica

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“…Fadare et al, reported 25% and Rubin et al, reported 30% detection rate, while Colgan et al, revealed 50% detection rate. [8][9][10] As much as 90% positive cytology detection rate has also been reported in a study. 11 This can be due to the inclusion of ascitic fluid along with peritoneal washings, as ascitic fluid has a much higher rate of detecting malignant cells.…”

Section: Discussionmentioning

confidence: 84%

“…Fadare et al, reported 71.4% of serous carcinoma (n = 57), 55 % of endometrioid carcinoma (n = 30), 20% of clear cell carcinoma (n = 19), and 50 % of mucinous carcinoma (n = 13) showing positive peritoneal cytology. 8 Similar study by Rubin et al, analyzed 96 cases of ovarian tumors of which 29 cases showed positive peritoneal washing cytology.…”

Section: Discussionmentioning

confidence: 88%

An observational study of cytopathological analysis of ascitic fluid or peritoneal washings cytology in ovarian neoplasms: correlation with histopathological parameters

Jaswani

Gupta

2018

Int J Res Med Sci

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Background: Analysis of ascitic fluid and peritoneal washing cytology serves as a useful predictor of ovarian surface involvement and peritoneal metastasis even in the absence of clinical omental spread. The aim of the current study is to correlate peritoneal cytology with various histologic features of ovarian cancers.Methods: It is a retrospective study. A total of 30 cases of ovarian neoplasms were included in the study. Results of peritoneal cytology were correlated with various histologic features of ovarian tumors including histologic type, grade, tumor size, capsular invasion, and omental metastasis, using chi-square test. A p value of <0.05 was considered as statistically significant.Results: Out of the 30 cases of ovarian tumors involved in the study, twenty-five cases were surface epithelial tumors, two sex-cord stromal tumors, one germ cell tumor, one primary ovarian lymphoma and one metastatic carcinoma. Capsular invasion was seen in 56.3 % of the cases, and omental metastasis in 46.6 % of the cases. A significant positive correlation was seen between positive peritoneal cytology and capsular invasion and omental metastasis with a p value of <0.001.Conclusions: Peritoneal fluid cytology is an indicator of peritoneal metastasis. Positive cytology also correlates with capsular invasion and histologic type in ovarian tumors. Therefore, it should always be used as an adjunctive tool in the surgical management of ovarian tumors.

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Peritoneal washing cytologic analysis of ovarian serous tumors of low malignant potential to detect peritoneal implants and predict clinical outcome

Sneige

Thomison

Malpica

et al. 2012

Cancer Cytopathology

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Background Patients with ovarian serous tumors of low malignant potential (OSLMP) who have peritoneal implants, especially invasive implants, are at increased risk of developing tumor recurrence. The ability of peritoneal washing (PW) cytology, to detect the presence and type of peritoneal implants has not been adequately investigated, and its prognostic significance is unknown. Methods We retrospectively reviewed records and PW specimens of 101 patients diagnosed with and treated for OSLMP between 1996 and 2010 at The University of Texas MD Anderson Cancer Center. We compared patients’ staging biopsy findings with those of our review of the PWs. Follow-up data were also analyzed. Results Of the 96 patients with staging biopsy results available, 26 (27%) had peritoneal implants (17 noninvasive, 9 invasive), 19 (20%) had endosalpingiosis, and 51 (53%) had negative findings. The PW specimens of 18 of the 26 patients (69%) with peritoneal implants were positive for serous neoplasm, and a correlation was found between cytologic and histologic findings (p < 0.0001). The sensitivity, specificity, positive predictive, and negative predictive values were 69%, 84%, 62% and 88%, respectively. Four of 101 patients had disease recurrence, 3 of these patients had invasive implants and 1 patient had noninvasive implants. None of the patients who had negative staging biopsy findings or endosalpingiosis but PW specimens positive for serous neoplasm developed disease recurrence. Conclusions PW cytology detects the presence of peritoneal implants with moderate accuracy. Long-term studies are needed to determine whether positive PW cytologic findings are an independent predictor of tumor recurrence.

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The histologic subtype of ovarian tumors affects the detection rate by pelvic washings

Cited by 23 publications

References 80 publications

Significance of Peritoneal Washing Cytopathology in Ovarian Carcinomas and Tumors of Low Malignant Potential: A Quality Control Study with Literature Review

Significance of Peritoneal Washing Cytopathology in Ovarian Carcinomas and Tumors of Low Malignant Potential: A Quality Control Study with Literature Review

An observational study of cytopathological analysis of ascitic fluid or peritoneal washings cytology in ovarian neoplasms: correlation with histopathological parameters

Peritoneal washing cytologic analysis of ovarian serous tumors of low malignant potential to detect peritoneal implants and predict clinical outcome

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