The Histologic Spectrum of Prepuces from Patients with Phimosis

Clemmensen, Ole; Krogh, John; Petri, Michael

doi:10.1097/00000372-198804000-00002

Cited by 54 publications

(17 citation statements)

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“…[8485] Histological examination of foreskins removed for various reasons revealed LS in 3.6%–19%. [868788899091] A study in Plymouth, UK, of 422 boys aged 3 months to 16 years (mean 6 years) referred to a pediatric general surgical outpatient department with foreskin problems found 55.9% were normal, with the remainder (44.1%) undergoing surgery: 35% circumcision, 8% preputial adhesiolysis, and 0.1% frenuloplasty. [75] Histological abnormalities were seen in 85% of the foreskins removed by circumcision; chronic inflammation was seen in 47%, LS in 35%, fibrosis in 3%, and 13% were histologically normal.…”

Section: Resultsmentioning

confidence: 99%

Penile inflammatory skin disorders and the preventive role of circumcision

Morris

Krieger

2017

Int J Prev Med

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Penile inflammatory skin conditions such as balanitis and posthitis are common, especially in uncircumcised males, and feature prominently in medical consultations. We conducted a systematic review of the medical literature on PubMed, EMBASE, and Cohrane databases using keywords “balanitis,” “posthitis,” “balanoposthitis,” “lichen sclerosus,” “penile inflammation,” and “inflammation penis,” along with “circumcision,” “circumcised,” and “uncircumcised.” Balanitis is the most common inflammatory disease of the penis. The accumulation of yeasts and other microorganisms under the foreskin contributes to inflammation of the surrounding penile tissue. The clinical presentation of inflammatory penile conditions includes itching, tenderness, and pain. Penile inflammation is responsible for significant morbidity, including acquired phimosis, balanoposthitis, and lichen sclerosus. Medical treatment can be challenging and a cost burden to the health system. Reducing prevalence is therefore important. While topical antifungal creams can be used, usually accompanied by advice on hygiene, the definitive treatment is circumcision. Data from meta-analyses showed that circumcised males have a 68% lower prevalence of balanitis than uncircumcised males and that balanitis is accompanied by a 3.8-fold increase in risk of penile cancer. Because of the high prevalence and morbidity of penile inflammation, especially in immunocompromised and diabetic patients, circumcision should be more widely adopted globally and is best performed early in infancy.

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Section: Resultsmentioning

confidence: 99%

Penile inflammatory skin disorders and the preventive role of circumcision

Morris

Krieger

2017

Int J Prev Med

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“…The histopathological spectrum of BXO varies according to different classification, from early atypical changes to the typical fibrosing type. [7,8] However, any change within this spectrum has to be considered significant as it represents a precursor lesion that might develop to a full process. Without histopathology of circumcised foreskin, five of eight patients (62%) with BXO would have been missed in our study.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7] Peritonitis follows typhoid enteric perforation. [8] Management of typhoid enteric perforation is surgically challenging. There are various surgical treatment options for typhoid enteric perforation [8][9][10][11][12] but the superiority of any one procedure over the other remains controversial.…”

Section: Discussionmentioning

confidence: 99%

“…[8] Management of typhoid enteric perforation is surgically challenging. There are various surgical treatment options for typhoid enteric perforation [8][9][10][11][12] but the superiority of any one procedure over the other remains controversial. [8] However, simple, quick and less traumatic surgical procedure is advocated in the treatment of typhoid enteric perforation.…”

Section: Discussionmentioning

confidence: 99%

“…There are various surgical treatment options for typhoid enteric perforation [8][9][10][11][12] but the superiority of any one procedure over the other remains controversial. [8] However, simple, quick and less traumatic surgical procedure is advocated in the treatment of typhoid enteric perforation. [10] This study reviewed single versus doublelayer intestinal closure in the surgical management of typhoid intestinal perforations in children in our centre.…”

Section: Discussionmentioning

confidence: 99%

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