The histologic features of intratubular germ cell neoplasia and its correlation with tumor behavior

Basiri, Abbas; Movahhed, Saeed; Parvin, Mahmood; Salimi, Maziar; Rezaeetalab, Gholam Hossein

doi:10.4111/icu.2016.57.3.191

Cited by 4 publications

(2 citation statements)

References 22 publications

(32 reference statements)

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“…Of patients undergoing radical orchiectomy, 80-90% have simultaneous ITGCN in adjacent testicular tissue (29). This suggests that ITGCN would be more likely to be present in the peripheral testicular parenchyma next to the excised tumor during partial orchiectomy.…”

Section: Discussionmentioning

confidence: 99%

Additional Preoperative Parameters to Enable the Decision of Partial Orchiectomy in Small Testicular Masses

Selvi¹,

Başar²

2020

Bezmialem Science

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Amaç:Tek taraflı, küçük (≤2 cm) testiküler kitlelerin preoperatif değerlendirmesinde, benign-malign ayrımını yapabilmede kullanılabilecek ek klinik parametrelerin öngörü değerini araştırarak, parsiyel orşiektomi uygulanabilecek hastaları belirlemeyi amaçladık.Yöntemler: Ocak 2010-Aralık 2017 tarihleri arasında radikal orşiektomi yapılan tek taraflı, küçük testiküler kitleye sahip 31 hastanın verileri retrospektif olarak incelendi. Hastaların demografik verileri, histopatolojik tümör tipleri, serum tümör belirteçleri, nötrofil/lenfosit oranı (NLR), monosit/lenfosit oranı (MLR), platelet/lenfosit oranı (PLO), ortalama platelet hacmi (MPV), eritrosit dağılım genişliği (RDW), testiküler disgenezis sendromu (TDS) ve bileşenlerinin varlığı, postoperatif takip verileri kaydedildi. Hastalar tümör histopatolojisine göre benign ve malign olarak iki gruba ayrılarak karşılaştırıldı.Bulgular: Ortalama tanı yaşı 29,39±5,90 olan 31 hastanın 11'i benign, 20'si malign patolojiye sahipti. İki grup arasında AFP (p=0,116), β-hCG (p=0,205), LDH (p=0,606), MPV (p=0,087) ve RDW (p=0,266) açısından anlamlı fark görülmezken; malign grupta MLR (p=0,001), NLR (p=0,036) ve PLR (p=0,001) anlamlı olarak daha yüksekti. Testiküler mikrolitiazis (p=0,719), inmemiş testis (p=0,254), hipospadias (p=0,645), atrofik testis (p=0,409) saptanma oranları gruplar arasında farklılık göstermezken; semen parametresi bozukluğu oranı (p=0,043) ve TDS varlığı (p=0,043) malign olgularda belirgin olarak yüksek bulundu. Çok değişkenli Objective: We aimed to determine the predictive value of additional parameters for differentiating benign-malign tumors and to identify optimal patients for partial orchiectomy in unilateral, small (≤2 cm) testicular masses. Methods:The data of 31 patients who underwent radical orchiectomy between January 2010 and December 2017 due to unilateral and small testicular masses were retrospectively analyzed. Demographic data, histopathological tumor types, serum tumor markers, neutrophil/lymphocyte ratio (NLR), monocyte/ lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV), red cell distribution width (RDW), the presence of testicular dysgenesis syndrome (TDS) and its components, postoperative follow-up outcomes were recorded. Patients were divided into two groups as benign and malignant.Results: There was no significant difference between groups in terms of AFP (p=0.116), β-hCG (p=0.205), LDH (p=0.606), MPV (p=0.087) and RDW (p=0.266); while MLR (p=0.001), NLR (p=0.036) and PLR (p=0.001) were significantly higher in malignant group. The presences of testicular microlithiasis (p=0.719), undescended testis (p=0.254), hypospadias (p=0.645), atrophic testis (p=0.409) were not different between groups; while the rate of disorders of semen parameters (p=0.043) and presence of TDS (p=0.043) were significantly higher in malignant cases.

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Section: Discussionmentioning

confidence: 99%

Additional Preoperative Parameters to Enable the Decision of Partial Orchiectomy in Small Testicular Masses

Selvi¹,

Başar²

2020

Bezmialem Science

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“…The histological heterogeneity and complexity within TGCTs allow for possible morphological overlaps and problematic areas for accurate diagnosis, for which IHC analysis is crucial [12,17,18]. The presence of GCNIS can only be confidently ascertained with IHC analysis, as the light microscopy of H&E slides underestimates its presence [19,20]. The final diagnosis of TGCTs is only possible after radical orchidectomy has been performed and the excised testis has undergone pathohistological examination.…”

Section: Introductionmentioning

confidence: 99%

Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry

Krasic,

Skara Abramovic,

Himelreich Peric

et al. 2023

Cells

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The accurate management of testicular germ cell tumors (TGCTs) depends on identifying the individual histological tumor components. Currently available data on protein expression in TGCTs are limited. The human protein atlas (HPA) is a comprehensive resource presenting the expression and localization of proteins across tissue types and diseases. In this study, we have compared the data from the HPA with our in-house immunohistochemistry on core TGCT diagnostic genes to test reliability and potential biomarker genes. We have compared the protein expression of 15 genes in TGCT patients and non-neoplastic testicles with the data from the HPA. Protein expression was converted into diagnostic positivity. Our study discovered discrepancies in three of the six core TGCT diagnostic genes, POU5F1, KIT and SOX17 in HPA. DPPA3, CALCA and TDGF1 were presented as potential novel TGCT biomarkers. MGMT was confirmed while RASSF1 and PRSS21 were identified as biomarkers of healthy testicular tissue. Finally, SALL4, SOX17, RASSF1 and PRSS21 dysregulation in the surrounding testicular tissue with complete preserved spermatogenesis of TGCT patients was detected, a potential early sign of neoplastic transformation. We highlight the importance of a multidisciplinary collaborative approach to fully understand the protein landscape of human testis and its pathologies.

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Pluripotent Very Small Embryonic-Like Stem Cells in Adult Testes – An Alternate Premise to Explain Testicular Germ Cell Tumors

Kaushik

Bhartiya

2018

Stem Cell Rev and Rep

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The histologic features of intratubular germ cell neoplasia and its correlation with tumor behavior

Cited by 4 publications

References 22 publications

Additional Preoperative Parameters to Enable the Decision of Partial Orchiectomy in Small Testicular Masses

Additional Preoperative Parameters to Enable the Decision of Partial Orchiectomy in Small Testicular Masses

Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry

Pluripotent Very Small Embryonic-Like Stem Cells in Adult Testes – An Alternate Premise to Explain Testicular Germ Cell Tumors

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