The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy

Moon, James; Reed, Emma; Sheppard, Mary N.; Elkington, Andrew G.; Ho, Siew Yen; Burke, Margaret; Petrou, Mario; Pennell, Dudley J.

doi:10.1016/j.jacc.2004.03.035

Cited by 612 publications

(415 citation statements)

References 20 publications

(20 reference statements)

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“…6---8 LGE imaging is a particularly valuable method for identifying areas of fibrosis and to determine their extent and distribution. 9,10 Characteristics of the study population…”

Section: Discussionmentioning

confidence: 99%

Phenotypic expression in hypertrophic cardiomyopathy and late gadolinium enhancement on cardiac magnetic resonance

Caetano

Botelho

Trigo

et al. 2014

Revista Portuguesa de Cardiologia (English Edition)

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Introduction and Aim:The prognostic value of late gadolinium enhancement (LGE) for risk stratification of hypertrophic cardiomyopathy (HCM) patients is the subject of disagreement. We set out to examine the association between clinical and morphological variables, risk factors for sudden cardiac death and LGE in HCM patients. Methods: From a population of 78 patients with HCM, we studied 53 who underwent cardiac magnetic resonance. They were divided into two groups according to the presence or absence of LGE. Ventricular arrhythmias and morbidity and mortality during follow-up were analyzed. Results: Patients with LGE were younger at the time of diagnosis (p=0.046) and more often had a family history of sudden death (p=0.008) and known coronary artery disease (p=0.086). On echocardiography they had greater maximum wall thickness (p=0.007) and left atrial area (p=0.037) and volume (p=0.035), and more often presented a restrictive pattern of diastolic dysfunction (p=0.011) with a higher E/E ratio (p=0.003) and left ventricular systolic dysfunction (p=0.038). Cardiac magnetic resonance supported the association between LGE and previous echocardiographic findings: greater left atrial area (p=0.029) and maximum wall thickness (p<0.001) and lower left ventricular ejection fraction (p=0.056). Patients with LGE more often had an implantable cardioverter-defibrillator (ICD) (p=0.015). At follow-up, no differences were found in the frequency of ventricular arrhythmias, appropriate ICD therapies or mortality. Conclusions:The presence of LGE emerges as a risk marker, associated with the classical predictors of sudden cardiac death in this population. However, larger studies are required to confirm its independent association with clinical events. PALAVRAS-CHAVE

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“…6---8 LGE imaging is a particularly valuable method for identifying areas of fibrosis and to determine their extent and distribution. 9,10 Characteristics of the study population…”

Section: Discussionmentioning

confidence: 99%

Phenotypic expression in hypertrophic cardiomyopathy and late gadolinium enhancement on cardiac magnetic resonance

Caetano

Botelho

Trigo

et al. 2014

Revista Portuguesa de Cardiologia (English Edition)

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“…106 The most commonly identified phenotypic variant of HCM is asymmetric hypertrophy, preferably localized within the basal segment of the anterior septum. This type is associated with LVOTO in 20-30% of cases 108,109 and usually the LV ejection fraction is preserved. Evidence suggests that wall hypocontractility may develop before hypertrophy becomes evident.…”

Section: The Role Of Echocardiography In Hcm Diagnosismentioning

confidence: 99%

“…108,124 Non-invasive injection of the contrast agent helps describe tissue characteristics and may identify interstitial and replacement fibrosis typical for HCM. (LGE appears in 80% of patients with HCM, most commonly in the middle third of the left ventricular wall).…”

mentioning

confidence: 99%

The mechanisms, diagnosis and management of mitral regurgitation in mitral valve prolapse and hypertrophic cardiomyopathy

Popa

Irimia

Papagheorghe

et al. 2016

Discoveries (Craiova)

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“…LV outflow tract obstruction can be identified (101) and quantified before and after therapeutic septal artery embolization; the change in outflow tract dimensions was shown to correlate with the improvement of the patient's symptoms ( Figure 5) (102). On histology, the disease is known to cause myofibrillar disarray and fibroses at the insertion sites of the RV wall; this is reflected by a signal increase on late enhancement imaging in those regions (103)(104)(105). Some studies (104) suggested that an increasing amount of fibrotic areas correlates with increasing clinical predictors for sudden cardiac death in patients with hypertrophic cardiomyopathy.…”

Section: Identification Of Etiology Hypertrophic Cardiomyopathymentioning

confidence: 99%

The emerging clinical role of cardiovascular magnetic resonance imaging

Kumar¹,

Patton²,

Friedrich³

2010

Canadian Journal of Cardiology

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The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy

Abstract: In this patient with HCM and heart failure, regions of myocardial late gadolinium enhancement by CMR represented regions of increased myocardial collagen but not disarray.

Cited by 612 publications

References 20 publications

Phenotypic expression in hypertrophic cardiomyopathy and late gadolinium enhancement on cardiac magnetic resonance

Phenotypic expression in hypertrophic cardiomyopathy and late gadolinium enhancement on cardiac magnetic resonance

The mechanisms, diagnosis and management of mitral regurgitation in mitral valve prolapse and hypertrophic cardiomyopathy

The emerging clinical role of cardiovascular magnetic resonance imaging

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