The histogenesis of the “adenomatoid” tumor of the genital tract

Jackson, Jessica

doi:10.1002/1097-0142(195803/04)11:2<337::aid-cncr2820110218>3.0.co;2-0

Cited by 89 publications

(30 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Variably described as follicular inflammatory infiltrates, lymphocyte collections, chronic lymphoid follicles, or lymphoid aggregates (with or without germinal centers), 19,22,25,[34][35][36] these chronic inflammatory cell clusters/follicles have been reported to be useful diagnostic features of all genital tract adenomatoid tumors 36,37 despite a lack of formal appraisal across gender and site. Although an initial study in uterine/fallopian tube adenomatoid tumors reported 'inflammation' in up to 80% of cases, 35 only one other study to our knowledge has formally evaluated lymphoid aggregates in uterine adenomatoid tumors.…”

Section: Discussionmentioning

confidence: 99%

“…22 Since then, both ultrastructural and immunohistochemical studies of male and female genital tract adenomatoid tumors have shown support for a mesothelial origin. 12, Of the markers reported to have superior sensitivity in identifying mesothelialassociated neoplasms, [42][43][44][45][46] calretinin, D2-40, WT-1, CK5/6, and caldesmon were selected to determine immunoreactivity in both male and female genital tract adenomatoid tumors, with pankeratin staining used to corroborate the location and extent of tumor.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases

et al. 2009

View full text Add to dashboard Cite

Adenomatoid tumors of the female and male genital tracts are well characterized as mesothelial in origin, but a detailed histological and immunohistochemical analysis comparing both traditional and newer mesothelial markers across gender and site has not been formally conducted. A variety of morphologic features previously described as characteristic of adenomatoid tumors were evaluated in 44 adenomatoid tumors from the male and female genital tracts. Immunohistochemical analysis with pankeratin (AE1/CAM5.2), WT-1, calretinin, CK5/6, D2-40, and caldesmon was also performed. The extent and intensity of staining were scored semiquantitatively on one representative section per case and mean value for each parameter was calculated. All (n ¼ 44) the adenomatoid tumors from both the female and male genital tracts demonstrated a distinctive thread-like bridging strand pattern. Lymphoid aggregates were seen in all 12 adenomatoid tumors of male patients, but in only 4 of 32 (13%) tumors in female patients (Po0.0001). The remaining morphologic features were variably present with no clear sex predilection. Pankeratin, calretinin, and D2-40 reactivity were identified in all female (n ¼ 32) and male (n ¼ 12) genital tract adenomatoid tumors. Adenomatoid tumors expressed WT-1 in 11/12 (92%) male patients and in 31/32 (97%) female patients. In male patients, reactivity for CK5/6 and caldesmon was found in 1/12 (8%) and 0/12 (0%) adenomatoid tumors (respectively), whereas reactivity in female patients was found in 5/32 (16%) and 1/32 (3%); respectively. Female tumors differ from their male counterparts by the frequent absence of lymphoid aggregates and the presence of a circumscribed margin when occurring in the fallopian tube. Of the putative mesothelial markers evaluated, calretinin, D2-40, and WT-1 show a similar immunoprofile and have a higher sensitivity than CK5/6 and caldesmon in genital tract adenomatoid tumors. However, the presence of additional, often strong expression of WT-1 in normal tissues of the female genital tract limits the utility of WT-1 in this setting.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Der Ursprung dieser Tumoren wird seit ihrer Erstbeschreibung kontrovers diskutiert. Es wurde ein Ursprung aus Nebenhodenepithel, Endothel, Mesothel, mesonephrischem Epithel und Müller-Mesenchym vorgeschlagen [21]. Ultrastrukturell ist es unmöglich, zwischen den Zellen eines Mesothelioms und denen eines Adenomatoidtumors zu unterscheiden [22,23,24].…”

Section: Pathologische Resultateunclassified

Adenomatoider Tumor der Nebenniere

Schadde

Meissner²,

Kroetz³

et al. 2003

Chirurg

View full text Add to dashboard Cite

Adenomatoid tumors are uncommon, benign tumors of the genital tract which have also been reported to occur extragenitally. Case reports on adenomatoid tumors of the adrenal gland exist. Most of these are incidentally discovered at autopsy or after the resection of incidentalomas. We report on the case of a young man with epigastic pain and with the finding of a 4 cm heterogeneous right adrenal mass on abdominal CT scan. After endocrine activity had been ruled out, an inactive, benign adrenal tumor was suspected and laparoscopic right adrenalectomy performed. The specimen was found to be an adenomatoid tumor. We discuss the differential diagnosis and the possible embryological origin of these tumors. The feature of 'local invasive ability' does not imply malignancy. All cases discovered surgically and at autopsy have been benign. Local resection seems to be the appropriate therapy.

show abstract

“…3,4,10 Histogenesis of ATE is not clear where few pathologists consider it to be a reaction to injury or inflammation, most have believed it to be of mesothelial origin. 11 On electron microscopy, it can present in a wide spectrum however basic patterns being three only i.e. tubules, cell nests and cords.…”

Section: Discussionmentioning

confidence: 99%