The hippocampus: normal anatomy and pathology.

Hayman, L. Anne; Fuller, Gregory N.; Cavazos, José E; Pfleger, M J; Meyers, Craig; Jackson, Edward F.

doi:10.2214/ajr.171.4.9763010

Cited by 30 publications

(21 citation statements)

References 2 publications

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“…It is thus possible that the effect of age on CA1 volume found in Mueller et al's studies reflected an age effect on these parts of the subiculum that were included in the subiculum subfield in our study. Note that the definition of the CA1-subiculum boundary is particularly inconsistent across neuroimaging studies, using either a very medial position leading to an over-estimation of the volume of CA1 (Mueller et al, 2007;Yushkevich et al, 2009) or the lateral extremity resulting in over-estimating the subiculum volume (Hayman et al, 1998;Van Leemput et al, 2009). This difference may explain general discrepancies between studies regarding the Fig.…”

Section: Discussionmentioning

confidence: 99%

Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence

et al. 2010

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Recent advances in neuroimaging have highlighted the interest to differentiate hippocampal subfields for cognitive neurosciences and more notably in assessing the effects of normal and pathological aging. The main goal of the present study is to investigate the effects of normal aging onto the volume of the different hippocampal subfields. For this purpose, we developed a new magnetic resonance sequence together with reliable tracing guidelines to assess the volume of different subfields of the hippocampus using a 3 Tesla scanner, and estimated the validity of a simpler and less time-consuming method based on the widely-used automatic Voxel-Based Morphometry (VBM) technique. Three hippocampal regions of interest were delineated on the right and left hippocampi of 50 healthy subjects between 18 and 68 years old corresponding to the CA1, subiculum and other (including CA2-3-4 and Dentate Gyrus) subfields. A strong effect of age was found on the volume of the subiculum only, with a decrease paralleling that of the global gray matter volume, while CA1 and other subfields seemed relatively spared. Although less precise than the ROI-tracing technique, the VBM-based method appeared as a reliable alternative especially to distinguish CA1 and subiculum subfields. Our findings of a specific effect of age on the subiculum are consistent with the developmental hypothesis ("last-in first-out" theory). This contrasts with the predominant vulnerability of the CA1 subfield to Alzheimer's disease reported in several previous studies, suggesting that the assessment of hippocampal subfields may improve the discrimination between normal and pathological aging.

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Section: Discussionmentioning

confidence: 99%

Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence

et al. 2010

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“…Researchers in previous literature (1,8) have suggested nonarteriosclerotic disease as the cause for lentiform nucleus calcification, but whether the causes of calcification of the hippocampus and lentiform nuclei are related is uncertain. In most people, the dominant left hippocampus primarily mediates verbal learning and memory, whereas the nondominant right side primarily mediates nonverbal memory (9). However, Wegiel et al (2) demonstrated an almost identical prevalence of vascular fibrosis and calcification in a cohort with Alzheimer disease and an age-matched control cohort without Alzheimer disease.…”

Section: Location Of Intrahippocampal Calcificationmentioning

confidence: 99%

Hippocampal Calcification Prevalence at CT: A Retrospective Review

Chew¹,

Gupta

Alatakis

et al. 2012

Radiology

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“…The hippocampus is a complex and fascinating region of the brain and has enormous clinical significance regarding memory problems [1]. Because the hippocampus is thought to play a central role in memory, there has been considerable interest in the possibility that age-related declines could be caused by hippocampal deterioration [2,3].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effects of Sodium Butyrate, a Histone Deacetylase Inhibitor, on Increase of Neurogenesis Induced by Pyridoxine and Increase of Neural Proliferation in the Mouse Dentate Gyrus

et al. 2011

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We previously observed that pyridoxine (vitamin B(6)) significantly increased cell proliferation and neuroblast differentiation without any neuronal damage in the hippocampus. In this study, we investigated the effects of sodium butyrate, a histone deacetylase (HDAC) inhibitor which serves as an epigenetic regulator of gene expression, on pyridoxine-induced neural proliferation and neurogenesis induced by the increase of neural proliferation in the mouse dentate gyrus. Sodium butyrate (300 mg/kg, subcutaneously), pyridoxine (350 mg/kg, intraperitoneally), or combination with sodium butyrate were administered to 8-week-old mice twice a day and once a day, respectively, for 14 days. The administration of sodium butyrate significantly increased acetyl-histone H3 levels in the dentate gyrus. Sodium butyrate alone did not show the significant increase of cell proliferation in the dentate gyrus. But, pyridoxine alone significantly increased cell proliferation. Sodium butyrate in combination with pyridoxine robustly enhanced cell proliferation and neurogenesis induced by the increase of neural proliferation in the dentate gyrus, showing that sodium butyrate treatment distinctively enhanced development of neuroblast dendrites. These results indicate that an inhibition of HDAC synergistically promotes neurogenesis induced by a pyridoxine and increase of neural proliferation.

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The hippocampus: normal anatomy and pathology.

Cited by 30 publications

References 2 publications

Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence

Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence

Hippocampal Calcification Prevalence at CT: A Retrospective Review

Synergistic Effects of Sodium Butyrate, a Histone Deacetylase Inhibitor, on Increase of Neurogenesis Induced by Pyridoxine and Increase of Neural Proliferation in the Mouse Dentate Gyrus

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