The hippocampus and reward: Effects of hippocampal lesions on progressive-ratio responding.

Schmelzeis, Mary C.; Mittleman, Guy

doi:10.1037/0735-7044.110.5.1049

Cited by 73 publications

(74 citation statements)

References 80 publications

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“…These animals also consistently exhibited higher maximal response rates during self-stimulation tests. Collectively, these novel results extend previous demonstrations of the involvement of the hippocampal formation in motor output and rewarded behavior [5,9,17,24,48,49] by demonstrating that lesions of this structure can dramatically alter behaviors traditionally ascribed to the mesoaccumbens DA system [2,13,14,29,[43][44][45].…”

Section: Discussionsupporting

confidence: 83%

“…Evidence consistent with this possibility has recently been presented [48]. In comparison to controls, rats with hippocampal lesions had significantly higher breakpoints in a progressive ratio, food reward task.…”

Section: Introductionsupporting

confidence: 58%

“…It has been shown that reward thresholds are lower during the presentation of an ascending current series, in comparison to random or descending current series [12,28]. Rats with hippocampal lesions have previously been described as being 'extremely sensitive' to contrast effects engendered by shifts in reward [31], and it has recently been reported that rats with extensive hippocampal damage were more sensitive than controls to 'increases' in the qualitative aspects of reward [48]. The current results confirm these earlier observations, and, in the case of ICSS, suggest that lesioned animals may be more sensitive to positive, rather than negative, contrasts.…”

Section: Discussionmentioning

confidence: 99%

“…First, maximal response rates for ICSS are usually considered to be a measure of motor performance [33]. Rats with hippocampal damage, produced by a variety of different methods, have been reported to display increased motor output in response to activating situations, food reward, and following drug administration [5,8,9,17,24,38,48,49,59,60]. These results may thus be another example of the enhancement in motor output resulting from hippocampal damage.…”

Section: Discussionmentioning

confidence: 99%

“…Because hippocampal damage enhances both motor output and incentive motivation [48,49], an additional goal of this was to determine if lesions of this structure altered reward processes or motor performance. In order to distinguish changes in reward sensitivity from changes in motor performance, the ICSS curve shift method was used (for reviews, see Refs.…”

Section: Introductionmentioning

confidence: 99%

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Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat

Kelley

Mittleman

1999

Behavioural Brain Research

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Kelley, Stephen P. and Mittleman, Guy (1999) AbstractThe main purpose of this study was to explore the role of the hippocampus in motivated behavior. Rats with bilateral excitotoxic lesions of the hippocampus and controls were trained to lever press for electrical stimulation of the ventral tegmental area. Rate-intensity functions were generated from an ascending and descending series of current intensities. Lesion-induced changes in sensitivity to reward were distinguished from enhancements in motor output by calculating reward thresholds and maximal response rates from the rate-intensity functions. Rats with hippocampal damage showed lower reward thresholds and higher maximal response rates than controls. These results provide further evidence of hippocampal modulation of the nucleus accumbens, suggesting that lesions of this structure enhance sensitivity to reward and increase motor output.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat

Kelley

Mittleman

1999

Behavioural Brain Research

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The hippocampus and appetitive Pavlovian conditioning: Effects of excitotoxic hippocampal lesions on conditioned locomotor activity and autoshaping

2005

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The hippocampus (HPC) is known to be critically involved in the formation of associations between contextual/spatial stimuli and behaviorally significant events, playing a pivotal role in learning and memory. However, increasing evidence indicates that the HPC is also essential for more basic motivational processes. The amygdala, by contrast, is important for learning about the motivational significance of discrete cues. This study investigated the effects of excitotoxic lesions of the rat HPC and the basolateral amygdala (BLA) on the acquisition of a number of appetitive behaviors known to be dependent on the formation of Pavlovian associations between a reward (food) and discrete stimuli or contexts: (1) conditioned/anticipatory locomotor activity to food delivered in a specific context and (2) autoshaping, where rats learn to show conditioned discriminated approach to a discrete visual CS+. While BLA lesions had minimal effects on conditioned locomotor activity, hippocampal lesions facilitated the development of both conditioned activity to food and autoshaping behavior, suggesting that hippocampal lesions may have increased the incentive motivational properties of food and associated conditioned stimuli, consistent with the hypothesis that the HPC is involved in inhibitory processes in appetitive conditioning.

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Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation

Davidson¹,

Chan²,

Jarrard³

et al. 2008

Hippocampus

175

131

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The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity general behavioral activity, conditioned appetitive responding). The testing conditions were designed to minimize the nonspecific debilitating effects of these surgeries on intake and body weight. Rats with CHip and VP lesions exhibited significantly greater weight gain and food intake compared to controls. Furthermore, CHip-lesioned rats, but not rats with VP lesions, showed elevated metabolic activity, general activity in the dark phase of the light-dark cycle, and greater conditioned appetitive behavior, compared to control rats without these brain lesions. In contrast, rats with mPFC lesions were not different from controls on any of these measures. These results indicate that hippocampal damage interferes with energy and body weight regulation, perhaps by disrupting higher-order learning and memory processes that contribute to the control of appetitive and consummatory behavior.Much research on the causes of overeating and excessive weight gain has been directed at identifying the brain regions where metabolic and hormonal signals that stimulate or suppress intake are detected and utilized (Benoit et al., 2004;Cummings and Overduin, 2007;Leibowitz and Wortley, 2004;Seeley et al., 2004). Although specification of these physiological substrates will be central to any comprehensive account of food intake regulation, it is now clear that such accounts must also consider the role of learning and memory in the control of eating and appetitive behavior (Davidson et al., 2005;Higgs, 2005;Sclafani, 1997;Woods and Ramsay, 2000). In recent years, the hippocampus, a brain structure long considered critical to the performance of a number of learning and memory functions (Eichenbaum, 2006;Squire, 2004), has received increasing attention related to its potential involvement in energy regulation.This increased interest in possible involvement of hippocampus in energy regulation is based, in part, on findings that neurohormonal signals involved with meal termination (e.g., cholecystokinin), meal initiation, (e.g., ghrelin) and signaling the status of bodily energy Please correspond with: Terry L. Davidson,

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The hippocampus and reward: Effects of hippocampal lesions on progressive-ratio responding.

Cited by 73 publications

References 80 publications

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat

Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat

The hippocampus and appetitive Pavlovian conditioning: Effects of excitotoxic hippocampal lesions on conditioned locomotor activity and autoshaping

Contributions of the hippocampus and medial prefrontal cortex to energy and body weight regulation

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