The Hippocampus

doi:10.1007/978-1-4684-2976-3

Cited by 122 publications

References 356 publications

(587 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Deficits in operant behavior and alteration of CA1, CA3 hippocampal dendritic arborization due to subicular lesions

Nutan

Meti

2000

J. Neurosci. Res.

View full text Add to dashboard Cite

The deficits in operant behavior and the alterations in dendritic arborizations of Cornu Ammonis 1 and Cornu Ammonis 3 (CA1 and CA3) hippocampal areas were investigated in subicular lesioned rats. The subjects were female Wistar rats aged 120 days, and were divided into four groups: one serving as age-matched untrained control, a second group received training and sham lesioning, a third group were only trained, and the fourth group were first trained and then subjected to subicular lesions. The rats were food-deprived 24 hours prior to operant behavior training sessions. Two training sessions for operant behavior with continuous reinforcement of 10 minutes duration per day were done during the shaping session, following which rats were allowed 10 minutes of operant food reward for 10 days. On the eleventh day, only the operant behavior and sham-operated rats were used for subicular lesion and sham surgery, respectively. After 72 hours of surgical recovery, operant behavioral testing was performed daily as before for a further period of 10 days. Later, all groups of rats were killed and the hippocampus was processed for rapid Golgi staining. Our results suggest that subicular lesions produce a significant reduction in operant learning. Further, the Golgi studies revealed a reduction in dendritic branching points and intersections of apical and basal CA1, CA3 neurons in lesioned rats.

show abstract

Deficits in operant behavior and alteration of CA1, CA3 hippocampal dendritic arborization due to subicular lesions

Nutan

Meti

2000

J. Neurosci. Res.

View full text Add to dashboard Cite

show abstract

Objectives of the Meeting

Gray

1978

Novartis Foundation Symposia

View full text Add to dashboard Cite

Differentiation of granule cell dendrites in the dentate gyrus of the rhesus monkey: A quantitative golgi study

Duffy

Rakić

1983

J of Comparative Neurology

103

View full text Add to dashboard Cite

The differentiation of granule cell dendrites in the dentate gyrus of the hippocampal region was studied in a series of developing fetal and postnatal rhesus monkeys whose brains were processed by the rapid Golgi method. The total combined lengths of dendrites, the total number of dendritic spines, and their density on the proximal, middle, and distal thirds of the dendritic shafts were determined at embryonic days 58, 95, 120, 153, term (165), postnatal days 3, 20, 60, 150, 365, and adults. At all ages examined, granule cells exhibited various levels of maturation with the more differentiated cells being situated in the superficial strata of the granular layer and the less mature cells lying in progressively deeper positions, thus conforming to the outside-to-inside spatiotemporal gradient of their genesis. Quantitative analysis shows that, in this primate, hippocampal granule cells differentiate mainly in the second half of gestation with all measured parameters attaining mature values by the time of birth. However, the analysis also reveals a transient phase of exuberant postnatal development which involves excessive dendritic branching, regional changes in dendritic length, overproduction of dendritic spines, and redistribution of spines within the molecular layer. After reaching peak values around the middle of the first year of life, these parameters decrease and in adult monkeys fall back to the neonatal level.

show abstract

The Hippocampus

Cited by 122 publications

References 356 publications

Deficits in operant behavior and alteration of CA1, CA3 hippocampal dendritic arborization due to subicular lesions

Deficits in operant behavior and alteration of CA1, CA3 hippocampal dendritic arborization due to subicular lesions

Objectives of the Meeting

Differentiation of granule cell dendrites in the dentate gyrus of the rhesus monkey: A quantitative golgi study

Contact Info

Product

Resources

About