The hippocampal–striatal axis in learning, prediction and goal-directed behavior

Pennartz, Cyriel M. A.; Ito, Rutsuko; Verschure, Paul F. M. J.; Battaglia, Francesco P.; Robbins, Trevor W.

doi:10.1016/j.tins.2011.08.001

Cited by 274 publications

(254 citation statements)

References 134 publications

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“…Motivation is a state of desire or energy to carry out a certain action, triggered by intrinsic or extrinsic factors (Pennartz et al, 2011). Motivation enhances performance and learning and is typically accompanied by increased arousal.…”

Section: Box 1: Terminologymentioning

confidence: 99%

“…Here, we will mainly focus on the approach tendency and define motivation as a state of desire or energy to carry out a certain action, triggered by intrinsic or extrinsic factors (Pennartz et al, 2011). Reward motivation entails the attribution of incentive salience and/or value, which has been summarized by Berridge and Robinson (2003) as cue-triggered 'wanting' (see Box 1).…”

Section: Reward Motivationmentioning

confidence: 99%

“…The integration of inputs to the VTA takes place in the ventral striatum. This input combines information about current motivational goals and task set from the PFC (mPFC in rats, vmPFC in humans, see Bromberg-Martin et al, 2010b as well as Rushworth et al, 2011 about the role of PFC), sensory stimulus properties from BLA/hippocampus, and the context of the memory from the hippocampus (Pennartz et al, 2011), and serves to either promote or inhibit goal-directed behaviors (Schultz, 2010). PFC participates in memory consolidation by assimilating new information with existing mental schemas (Preston and Eichenbaum, 2013), while emotional arousal can bias memory processing via connections between the amygdala and the hippocampus.…”

Section: Reward Motivation Promotes Learning and Memorymentioning

confidence: 99%

“…Both the anticipation and the consumption of reward influence learning through mechanisms converging in the ventral and dorsal striatum (Pennartz et al, 2011) and involving the release of dopamine. Dopamine neurons are found mainly in the VTA and the neighboring substantia nigra pars compacta (SNpc) (D'Ardenne et Fields et al, 2007;Luo et al, 2011).…”

Section: Role Of Dopamine In Learning and Memory Consolidationmentioning

confidence: 99%

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Influence of reward motivation on human declarative memory

Miendlarzewska

Bavelier

Schwartz

2016

Neuroscience & Biobehavioral Reviews

149

134

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a b s t r a c tMotivational relevance can prioritize information for memory encoding and consolidation based on reward value. In this review, we pinpoint the possible psychological and neural mechanisms by which reward promotes learning, from guiding attention to enhancing memory consolidation. We then discuss how reward value can spill-over from one conditioned stimulus to a non-conditioned stimulus. Such generalization can occur across perceptually similar items or through more complex relations, such as associative or logical inferences. Existing evidence suggests that the neurotransmitter dopamine boosts the formation of declarative memory for rewarded information and may also control the generalization of reward values. In particular, temporally-correlated activity in the hippocampus and in regions of the dopaminergic circuit may mediate value-based decisions and facilitate cross-item integration. Given the importance of generalization in learning, our review points to the need to study not only how reward affects later memory but how learned reward values may generalize to related representations and ultimately alter memory structure.

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Section: Box 1: Terminologymentioning

confidence: 99%

Section: Reward Motivationmentioning

confidence: 99%

Section: Reward Motivation Promotes Learning and Memorymentioning

confidence: 99%

Section: Role Of Dopamine In Learning and Memory Consolidationmentioning

confidence: 99%

See 2 more Smart Citations

Influence of reward motivation on human declarative memory

Miendlarzewska

Bavelier

Schwartz

2016

Neuroscience & Biobehavioral Reviews

149

134

View full text Add to dashboard Cite

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“…It is known that these two hippocampal regions project differentially to other brain areas. The VH connects, for example, to the prefrontal cortex, amygdala, as well as the ventral and rostral sections of the nucleus accumbens (NAc)-ventral striatum (VS) shell associated with the regulation of context-dependent learning and emotional behaviour [32]. In contrast, the DH connects to the rostral part of the dorsal striatum (DS), including both the core and shell, dorsal lateral septum, mammillary bodies, anterior thalamus, ventral medial hypothalamus and anterior cingulate cortex [30].…”

Section: Introductionmentioning

confidence: 99%

Comparison of interval timing behaviour in mice following dorsal or ventral hippocampal lesions with mice having δ -opioid receptor gene deletion

Yin

Meck

2014

Phil. Trans. R. Soc. B

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Mice with cytotoxic lesions of the dorsal hippocampus (DH) underestimated 15 s and 45 s target durations in a bi-peak procedure as evidenced by proportional leftward shifts of the peak functions that emerged during training as a result of decreases in both ‘start’ and ‘stop’ times. In contrast, mice with lesions of the ventral hippocampus (VH) displayed rightward shifts that were immediately present and were largely limited to increases in the ‘stop’ time for the 45 s target duration. Moreover, the effects of the DH lesions were congruent with the scalar property of interval timing in that the 15 s and 45 s functions superimposed when plotted on a relative timescale, whereas the effects of the VH lesions violated the scalar property. Mice with DH lesions also showed enhanced reversal learning in comparison to control and VH lesioned mice. These results are compared with the timing distortions observed in mice lacking δ -opioid receptors (Oprd1 −/− ) which were similar to mice with DH lesions. Taken together, these results suggest a balance between hippocampal–striatal interactions for interval timing and demonstrate possible functional dissociations along the septotemporal axis of the hippocampus in terms of motivation, timed response thresholds and encoding in temporal memory.

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