The Hippocampal Formation in Schizophrenia

Tamminga, Carol A.; Stan, Ana D.; Wagner, Anthony D.

doi:10.1176/appi.ajp.2010.09081187

Cited by 518 publications

(494 citation statements)

References 234 publications

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“…In line with a recent study that reported greater hippocampal shape alterations in patients with schizophrenia and prior comorbid alcohol use disorders (Smith et al, 2011), we hypothesised that cannabis use would exert an additional effect on the hippocampal pathology typically observed in schizophrenia, particularly in the anterior hippocampus (Csernansky et al, 2002;Small et al, 2011;Tamminga et al, 2010).…”

Section: Introductionsupporting

confidence: 64%

Alteration to hippocampal shape in cannabis users with and without schizophrenia

Solowij

Walterfang

Lubman

et al. 2013

Schizophrenia Research

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Abnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users. There is a paucity of research investigating potential additive effects of cannabis use on brain pathology associated with schizophrenia. In this study, we performed hippocampal shape analysis in cannabis-using and non-using patients with schizophrenia, healthy cannabis users and healthy non-using controls. Hippocampal shape changes were observed in each group relative to controls, with the greatest degree of alterations (i.e., deflations across the hippocampus, and with an anterior predisposition), in cannabis-using schizophrenia patients. These alterations were associated with cannabis use patterns and psychotic symptoms. AbstractAbnormalities in hippocampal morphology are characteristic of schizophrenia and have also been reported in chronic cannabis users. There is a paucity of research investigating potential additive effects of cannabis use on brain pathology associated with schizophrenia. In this study we performed hippocampal shape analysis in cannabis-using and non-using patients with schizophrenia, healthy cannabis users and healthy non-using controls. Hippocampal shape changes were observed in each group relative to controls, with the greatest degree of alterations (i.e., deflations across the hippocampus, and with an anterior predisposition), in cannabis-using schizophrenia patients. These alterations were associated with cannabis use patterns and psychotic symptoms.

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Section: Introductionsupporting

confidence: 64%

Alteration to hippocampal shape in cannabis users with and without schizophrenia

Solowij

Walterfang

Lubman

et al. 2013

Schizophrenia Research

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“…Neuropathological studies of people with schizophrenia indicate the presence of cytoarchitectural abnormalities within cortical grey matter and particularly in hippocampus, typically reduced hippocampal volume (Tamminga et al, 2010). However, such findings are not always replicated (particularly if controls are family members) (Gothelf et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Grey-matter texture abnormalities and reduced hippocampal volume are distinguishing features of schizophrenia

Radulescu

Ganeshan

Shergill

et al. 2014

Psychiatry Research: Neuroimaging

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(2014) Grey-matter texture abnormalities and reduced hippocampal volume are distinguishing features of schizophrenia. Psychiatry Research: Neuroimaging, 223 (3). pp. [179][180][181][182][183][184][185][186] This version is available from Sussex Research Online: http://sro.sussex.ac.uk/50754/ This document is made available in accordance with publisher policies and may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the URL above for details on accessing the published version. Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. were also used as covariates in VBM analyses to test for correspondence with regional brain Author's Accepted Manuscriptvolume. Linear discriminant analysis tested if texture and volumetric data predicted diagnostic group membership (schizophrenia or control). We found that uniformity and entropy of grey matter differed significantly between individuals with schizophrenia and controls at the fine spatial scale (filter width below 2 mm). Within the schizophrenia group, these texture parameters correlated with volumes of the left hippocampus, right amygdala and cerebellum. The best predictor of diagnostic group membership was the combination of fine texture heterogeneity and left hippocampal size. This study highlights the presence of distributed grey-matter abnormalities in schizophrenia, and their relation to focal structural abnormality of the hippocampus. The conjunction of these features has potential as a neuroimaging endophenotype of schizophrenia.

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“…A consistent neuropathology in SZ is the subtle disruption of the anterior aspect of the hippocampal formation (Goldman and Mitchell, 2004;Harrison, 2004;Tamminga et al, 2010). While the specific, persistent chemoanatomical disruptions in the maturation of the hippocampus and its target regions following TTX on PD7 remain to be determined, they are likely to be more representative than the large, gross lesions produced by early ibotenic acid lesions of the VH.…”

Section: Ttx-induced Inactivation Of Developing Vh As An Animal Modelmentioning

confidence: 99%

Transient Inactivation of the Neonatal Ventral Hippocampus Impairs Attentional Set-Shifting Behavior: Reversal with an α7 Nicotinic Agonist

Brooks

Pershing

Thomsen

et al. 2012

Neuropsychopharmacol

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Cognitive deficits represent a core symptom cluster in schizophrenia that are thought to reflect developmental dysregulations within a neural system involving the ventral hippocampus (VH), nucleus accumbens (NAC), and prefrontal cortex (PFC). The present experiments determined the cognitive effects of transiently inactivating VH in rats during a sensitive period of development. Neonatal (postnatal day 7, PD7) and adolescent (PD32) male rats received a single bilateral infusion of saline or tetrodotoxin (TTX) within the VH to transiently inactivate local circuitry and efferent outflow. Rats were tested as adults on an attentional set-shifting task. Performance in this task depends upon the integrity of the PFC and NAC. TTX infusions did not affect the initial acquisition or ability to learn an intradimensional shift. However, TTX rats required a greater number of trials than did controls to acquire the first reversal and extradimensional shift (ED) stages. These impairments were age and region-specific as rats infused with TTX into the VH at PD32, or into the dorsal hippocampus at PD7, exhibited performance in the task similar to that of controls. Finally, acute systemic administration of the partial a7 nicotinic acetylcholine receptor (nAChR) agonist SSR 180711 (3.0 mg/kg) eliminated the TTX-induced performance deficits. Given that patients with schizophrenia exhibit hippocampal pathophysiology and deficits in the ED stages of set-shifting tasks, our results support the significance of transient hippocampal inactivation as an animal model for studying the cognitive impairments in schizophrenia as well as the pro-cognitive therapeutic potential of a7 nAChR agonists.

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The Hippocampal Formation in Schizophrenia

Cited by 518 publications

References 234 publications

Alteration to hippocampal shape in cannabis users with and without schizophrenia

Alteration to hippocampal shape in cannabis users with and without schizophrenia

Grey-matter texture abnormalities and reduced hippocampal volume are distinguishing features of schizophrenia

Transient Inactivation of the Neonatal Ventral Hippocampus Impairs Attentional Set-Shifting Behavior: Reversal with an α7 Nicotinic Agonist

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