The hippocampal commissure: a new finding at prenatal 3D ultrasound in fetuses with isolated complete agenesis of the corpus callosum

Contro, E.; Nanni, M.; Bellussi, Federica; Salsi, G.; Grisolia, Gianpaolo; Sanz-Cortés, Magdalena; Righini, Andrea; Rizzo, Nicola; Pilu, Gianluigi; Ghi, T.

doi:10.1002/pd.4645

Cited by 7 publications

(6 citation statements)

References 21 publications

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“…Vascular, toxic, genetic, and infectious (TORCH and Zika virus) etiologies have been described [6]. However, only <50% of the underlying cause is achieved [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Neurodevelopmental Outcomes following Prenatal Diagnosis of Isolated Corpus Callosum Agenesis: A Systematic Review

Cunha

Carneiro

Miguel³

et al. 2021

Fetal Diagn Ther

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Abnormalities of corpus callosum are one of the most common brain anomalies. Fetuses with isolated corpus callosum agenesis (CCA) have a better prognosis than those with additional anomalies. However, unpredictable neurodevelopmental outcomes of truly isolated CCA make prenatal counseling a challenge. The aim of this review is to evaluate neurodevelopmental outcomes in children with prenatal diagnosis of isolated CCA. Controlled clinical trials published between May 23, 2009, and May 23, 2019, using the MeSH term “agenesis of corpus callosum” were reviewed. A total of 942 articles were identified, and 8 studies were included in the systematic review depending on the inclusion criteria. These studies included 217 fetuses with isolated CCA and no other anomalies at prenatal assessment. Neurodevelopmental outcome was reported to be normal in 83 children with a prenatal diagnosis of isolated CCA confirmed at birth within 128 completed assessments. About 45 children presented borderline, moderate, or severe neurodevelopmental outcome. In this review, neurodevelopment was favorable in two-thirds of the cases, but mild disabilities emerged in older children. Despite this, disabilities can occur later beyond school age and a low risk of severe cognitive impairment exists. Our study highlights the essential early diagnosis and proper supportive therapy.

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“…Vascular, toxic, genetic, and infectious (TORCH and Zika virus) etiologies have been described [6]. However, only <50% of the underlying cause is achieved [9, 10].…”

Section: Introductionmentioning

confidence: 99%

Neurodevelopmental Outcomes following Prenatal Diagnosis of Isolated Corpus Callosum Agenesis: A Systematic Review

Cunha

Carneiro

Miguel³

et al. 2021

Fetal Diagn Ther

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“…17 The major limitation of this study is the lack of postnatal MR imaging in all cases because some neonates were submitted only to cranial sonography and some pregnancies were terminated, with brain deterioration not allowing an accurate postmortem analysis.…”

Section: Discussionmentioning

confidence: 99%

Variability of Forebrain Commissures in Callosal Agenesis: A Prenatal MR Imaging Study

Cesaretti

Nanni

Ghi

et al. 2015

AJNR Am J Neuroradiol

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“…[9,10] Recent neonatal and prenatal imaging studies suggest that corpus callosum agenesis occurs in at least 1:4,000 live births, [11] and other imaging studies demonstrated that 3-5% of the individuals assessed for neurodevelopmental disorders have corpus callosum agenesis. [12] In a prevelance study by Kidron et al [13] determined four distinct callosal defect groups which are complete (absence of all components), partial (presence of a short remnant), hypoplastic (thinning of the all parts of the corpus callosum), and mixed defects (partial corpus callosum agenesis with thinning of the residual part of the corpus callosum).…”

Section: Discussionmentioning

confidence: 99%

Partial corpus callosum agenesis and colpocephaly: a case report

Aydın¹,

Adıgüzel²,

Aksoy³

et al. 2016

Anatomy

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Callosal abnormalities are mostly described as central nervous system malformations and can be symptomatic or asymptomatic. Herein, we report an autopsy case of a 50-year-old Syrian immigrant male with poor academic performance, presented with partial agenesis of the corpus callosum and colpocephaly. He was evidently asymptomatic until death.The cause of death was determined to be hypothermia. Autosy revealed a corpus callosum of 3 cm only in the anterior part. Posterior part of the corpus callosum, anterior, posterior and hippocampal commissures were absent. On coronal sections, inferior horn of the lateral ventricle was dilated. Histopathological examination showed petechial microhemorrhagic areas and congestion in the brain. This case report was presented to demonstrate a good example of corpus callosum agenesis in asymptomatic individuals except for poor academic performance. Furthermore, this is the first corpus callosum agenesis in medical literature encountered during medicolegal autopsy in an adult case.

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The hippocampal commissure: a new finding at prenatal 3D ultrasound in fetuses with isolated complete agenesis of the corpus callosum

Cited by 7 publications

References 21 publications

Neurodevelopmental Outcomes following Prenatal Diagnosis of Isolated Corpus Callosum Agenesis: A Systematic Review

Neurodevelopmental Outcomes following Prenatal Diagnosis of Isolated Corpus Callosum Agenesis: A Systematic Review

Variability of Forebrain Commissures in Callosal Agenesis: A Prenatal MR Imaging Study

Partial corpus callosum agenesis and colpocephaly: a case report

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