The Hippo Pathway: A Master Regulatory Network Important in Cancer

Liu, Qiuping; Liu, Xiaomeng; Song, Guanbin

doi:10.3390/cells10061416

Cited by 17 publications

(19 citation statements)

References 89 publications

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“…Other important players involved in lipid metabolic reprogramming in cancer are the Hippo, Wnt/β-catenin, and JAK/STAT3 signaling pathways [35,36].…”

Section: Metabolic Alterations In Cancermentioning

confidence: 99%

Reprogramming of Lipid Metabolism in Lung Cancer: An Overview with Focus on EGFR-Mutated Non-Small Cell Lung Cancer

Eltayeb

Monica

Tiseo

et al. 2022

Cells

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Lung cancer is the leading cause of cancer deaths worldwide. Most of lung cancer cases are classified as non-small cell lung cancers (NSCLC). EGFR has become an important therapeutic target for the treatment of NSCLC patients, and inhibitors targeting the kinase domain of EGFR are currently used in clinical settings. Recently, an increasing interest has emerged toward understanding the mechanisms and biological consequences associated with lipid reprogramming in cancer. Increased uptake, synthesis, oxidation, or storage of lipids has been demonstrated to contribute to the growth of many types of cancer, including lung cancer. In this review, we provide an overview of metabolism in cancer and then explore in more detail the role of lipid metabolic reprogramming in lung cancer development and progression and in resistance to therapies, emphasizing its connection with EGFR signaling. In addition, we summarize the potential therapeutic approaches targeting lipid metabolism for lung cancer treatment.

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“…Other important players involved in lipid metabolic reprogramming in cancer are the Hippo, Wnt/β-catenin, and JAK/STAT3 signaling pathways [35,36].…”

Section: Metabolic Alterations In Cancermentioning

confidence: 99%

Reprogramming of Lipid Metabolism in Lung Cancer: An Overview with Focus on EGFR-Mutated Non-Small Cell Lung Cancer

Eltayeb

Monica

Tiseo

et al. 2022

Cells

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“…The regulatory module of the Hippo signaling pathway consists of kinases, including sterile 20 like kinase 1 and 2 (MST1/ MST2), Large Tumor Suppressor 1 and 2 (LATS1/ LATS2), Salvador homolog 1 (SAV1) and MOB Kinase activator 1A and 1B (MOB1A/ MOB1B) 58 , 59 . The switching “ON” and “OFF” of the Hippo signaling cascade is largely controlled by this series of core kinases as illustrated in Figure 1 .…”

Section: Regulation Of Hippo-yap Signaling Axis By Circrnasmentioning

confidence: 99%

Circular RNAs modulate Hippo-YAP signaling: functional mechanisms in cancer

Qadir¹,

Li²,

Yang³

2022

Theranostics

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The Hippo signaling pathway is an evolutionarily conserved network that regulates organ size and tissue homeostasis in mammals. This pathway controls various cell functions, such as growth, proliferation, survival, apoptosis, and stemness by switching 'on' or 'off' its inhibitory and/or transcriptional module, thereby regulating target gene(s) expression. Altered Hippo signaling has been implicated in various forms of cancers. Increasing evidence suggests cross-talk between the Hippo signaling pathway and non-coding RNAs, in particular circular RNAs (circRNAs). In this context, the current review presents the mechanistic interplay between the Hippo pathway and related circRNAs in various forms of cancers, along with the capabilities of these circRNAs to function either as tumor suppressors or oncogenes through miRNA sponging or protein binding mechanisms. Furthermore, we discuss the constraints and limitations in circRNA mechanistic studies while highlighting some outstanding questions regarding the roles of circRNAs associated with the Hippo-YAP pathway in cancer. Finally, we delineate the potential of these circRNAs to be employed as diagnostic and prognostic biomarkers, as well as molecular hotspots for cancer therapy.

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“…Similarly, differentially CEGs ( Figure 3 ) which are uniquely co-expressed in CSCs but not in GTCs could be indicative of the AML CSC-specific pathways. In this regard, Tyrosine metabolism ( Sun et al., 2020 ), Hippo signalling pathway ( Liu et al., 2021b ), and the Proteoglycans in cancer ( Ahrens et al., 2020 ) are amongst the currently known pathways to be associated with CSC functioning. Accordingly, the pathways and biological processes enriched by differentially CEGs could be further focused on in future studies concerning AML CSC functioning.…”

Section: Discussionmentioning

confidence: 99%