The hip fracture surgery in elderly patients (HIPELD) study to evaluate xenon anaesthesia for the prevention of postoperative delirium: a multicentre, randomized clinical trial

Abstract

EudraCT 2009-017153-35; ClinicalTrials.gov NCT01199276.

Neurologic and cognitive outcomes associated with the clinical use of xenon: a systematic review and meta-analysis of randomized-controlled trials

“…The results for postoperative delirium were mixed. The incidence of delirium was found to be lower after xenon anesthesia for coronary artery bypass surgery 38 but not hip fracture surgery 57 in adults. Xenon as an adjuvant to sevoflurane anesthesia reduced emergence agitation but not delirium in children (\ four years old) undergoing interventional or diagnostic cardiac catheterization.…”

“…1). Ten 34,35,38,39,[51][52][53][54][55]57,58 were published in English and seven 36,37,[47][48][49][50]56 in Russian or Ukrainian. No study published in Chinese met the inclusion criteria.…”

“…One RCT 35 investigated the effect of xenon plus therapeutic hypothermia in birth-related neonatal asphyxia. Thirteen RCTs 38,39,[47][48][49][50][52][53][54][55][56][57][58] compared xenon anesthesia with other inhaled agents or total intravenous anesthesia (propofol). Two studies 36,37 investigated the effect of xenon as an adjuvant therapy during the withdrawal phase of addictive substances.…”

Influence of xenon on pulmonary mechanics and lung aeration in patients with healthy lungs

“…Because the minimum alveolar concentration (MAC) of xenon has finally been estimated as 51e69% inspiratory concentration 23 and the synergistic effect of remifentanil with xenon on the MAC has to date been poorly investigated, a targeted inspiratory xenon concentration of 60% was chosen as the standard anaesthesia regimen for all patients, reflecting the practice in previous trials. 24 After xenon wash-in, when all measurements were completed, propofol infusion was discontinued and anaesthesia was maintained with xenon and remifentanil (0.15e0.3 mg kg À1 min À1 , titrated to clinical needs) until the end of surgery.…”

The Effect of Xenon-Based Anesthesia on Somatosensory-Evoked Potentials in Patients Undergoing Carotid Endarterectomy

“…It remains to be proven if the promising preclinical data regarding the neuroprotective properties of xenon 14,17,45,46,50 actually translate into improvement of patient outcome, which so far has not been easy to confirm. 27 In this context, the influence of xenon on SSEP monitoring will have to be accounted for when designing an appropriate trial.…”