“…Aromatic aldehydes, such as p-chlorobenzaldehyde, p-hydroxybenzaldehyde, 4-hydroxy-3methoxybenzaldehyde, 4-hydroxy-3-ethoxybenzaldehyde, and 4-hydroxy-3-methoxy-5-methyl-benzaldehyde, have been used as pivotal intermediates in the pharmaceutical, printing and dyeing, pesticide, cosmetic, ame retardant and spice industries. [4][5][6][7] Typically, p-hydroxybenzaldehyde is mainly used to synthesize the cardio-cerebrovascular medicine esmolol, the oral antibiotic amoxicillin, the antibacterial sulfa synergist trimethoxy benzylamine, the anti-hepatic uke nitroiodophenol nitrile, among others. [8][9][10][11] However, due to the outstanding water solubility of MADs, their highly efficient conversion has always been the focus of attention, especially under low MAD concentration.…”