The higher prevalence of developmental defects of enamel in the dioxin-affected region than non-dioxin-affected region: result from a cross-sectional study in Vietnam

Ngọc, Võ Trương Như; Hương, Lê Thị; Van, Nhon Bui; Tan, Ngo Thi Minh; Thuc, Pham Van; Hien, Vo Thi Thu; Dung, Truong Manh; Toàn, Nguyễn Văn; Anh, Le Quynh; Sơn, Lê Hoàng; Chu-Dinh, Thien; Chu, Dinh‐Toi

doi:10.1007/s10266-018-0358-1

Cited by 11 publications

(5 citation statements)

References 12 publications

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“…Ngoc et al (2019) performed a case–control study to investigate the effects of PCDD/Fs on the prevalence of enamel dysplasia in 2200 adults living in herbicide-sprayed and non-sprayed areas in Viet Nam [ 22 ]. The results indicated that enamel dysplasia occurred in 20.5% and 5.8% of adults living in the sprayed areas and the non-sprayed areas, respectively, suggesting that enamel dysplasia was almost twice as prevalent in the exposed population than in the control population [ 22 ]. Enamel dysplasia was more prevalent in the premolars than in the molars.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Polychlorinated Dibenzo-p-dioxins, Polychlorinated Dibenzofurans, and Dioxin-like PCBs on Teeth and Bones in Animals and Humans

Takiguchi

Nishino

2022

Toxics

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Bone metabolism is regulated by endocrine systems, so people exposed to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) may suffer adverse effects on bones and teeth. We reviewed previous publications in which effects of PCDD/Fs and dioxin-like polychlorinated biphenyls on the teeth and bones of animals and humans were found. The aim was to identify future research directions, particularly for epidemiological studies of populations exposed to PCDD/Fs in the environment. Exposure of fetuses to PCDD/Fs may affect odontogenesis, particularly enamel formation, but the effects of PCDD/Fs on bone genesis are limited to palatine bone. Exposure to PCDD/Fs in milk may affect both teeth and bones, but the effects on bones may be reversible. Exposure to high PCDD/F concentrations even during adulthood may adversely affect teeth. Exposure to PCDD/Fs may induce osteogenesis and improve bone properties because the disrupting effects of PCDD/Fs cause bone remodeling and vitamin D activation. More studies involving humans are required to investigate previously found associations between the PCDD/F concentrations humans are exposed to and biological markers for teeth and bones, including metabolites of vitamin D.

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Section: Resultsmentioning

confidence: 99%

“…Enamel dysplasia was more prevalent in the premolars than in the molars. Most lesions were found on the buccal surfaces of the teeth [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Effects of Polychlorinated Dibenzo-p-dioxins, Polychlorinated Dibenzofurans, and Dioxin-like PCBs on Teeth and Bones in Animals and Humans

Takiguchi

Nishino

2022

Toxics

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“…Chemical elements may cause an adverse effect on dental formation. An association appears to exist between aDDE and some toxins: radioactive contamination ( 120 ), dioxin exposure ( 121 ) (“Agent Orange”), chronic lead poisoning ( 122 ), and long- term exposure to PCBs ( 123 ) and excess fluoride ( 124 ).…”

Section: Methodsmentioning

confidence: 99%

Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review

et al. 2022

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BackgroundDevelopmental Defects of Enamel (DDE) is a pathology of the teeth that can greatly alter the quality of life of patients (hypersensitivity, esthetic issues, loss of function, etc.). The acquired DDE may occur as a result of a wide range of acquired etiological factors and his prevalence of this pathology may reach up to 89.9%. The main objective of this research was to identify and analyze, in current literature, the factors related to acquired DDE, in order to propose a general theory about the mechanisms involved.MethodsThe search of the primary literature was conducted until [December 31, 2021]. Our search strategy uses the Pubmed/MEDLINE database and was structured around 3 terms [“Development,” “Defect,” and “Enamel”]. To be included, references had to be primary studies, written in English. Exclusion criteria were reviews, in vitro, animal, genetic or archeology studies, and studies focused on clinical management of DDE. One hundred and twenty three articles were included in this scoping review: 4 Randomized clinical trials, 1 letter, 5 cases reports, 2 fundamentals studies, and 111 observational studies (33 Cross-sectional studies, 68 Cohort study and 10 Case-control study). The quality of evidence was assessed using the PEDro scale for clinical trials, the Newcastle-Ottawa scale for observational studies, and a published tool to assess the quality of case reports and case series.ResultsA scoping review of the literature identified 114 factors potentially involved in acquired DDE. The most frequently encountered pathologies are those causing a disorder of calcium homeostasis or a perturbation of the ARNT pathway in mother or child. The link between the ARNT pathway and metabolism deficiency in uncertain and needs to be defined. Also, the implication of this mechanism in tissue impairment is still unclear and needs to be explored.ConclusionsBy identifying and grouping the risk factors cited in the literature, this taxonomy and the hypotheses related to the mechanism allow health practitioners to adopt behaviors that limit the risk of developing aDDE and to set up a prevention of dental pathology. In addition, by reviewing the current literature, this work provides guidance for basic research, clinical studies, and literature searches.

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“…1,3,[7][8][9] The collected data were checked and analyzed by using statistical program SPSS (version 23.0, SPSS Inc., Chicago). 11,12 All variables were in a normal distribution with Kolmogorov-Smirnov test and normal quantile plots (data no shown). The two independent samples were analyzed using student's T-test, while multiple samples were analyzed using one-way ANOVA.…”

Section: Instead Of Formula: N = 313 Childrenmentioning

confidence: 99%

The dental arch dimensions in Vietnamese children at 7 years of age, and their variation by gender and ethnicity

Dung

Ngọc

Khoi

et al. 2019

Journal of Oral Biology and Craniofacial Research

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Dental arch dimensions are important not only in dentistry (e.g. orthodontists and prosthodontists, and forensic odontology), but also other medical fields, biology, biometrics, painting or sculpture. This study aimed to determine these dimensions in Vietnamese children and compare these measurements across four ethnic groups and genders. Methods: A cross-sectional study was conducted on 3204 Vietnamese children at 7 years of age from four major ethnic groups in Vietnam (Kinh, Tay, Thai and Muong). Results: The means variables in study subjects were 33.72 ± 2.16 mm for upper inter-canine width (UCW); 52.74 ± 2.55 mm for upper inter-molar width (UMW); 8.69 ± 1.79 mm for upper anterior length (UAL); 29.59 ± 1.97 mm for upper posterior length (UPL); 26.94 ± 2.49 mm for lower inter-canine width (LCW); 45.89 ± 2.59 mm for lower inter-molar width (LMW); 5.04 ± 1.53 mm for lower anterior length (LAL); and 26.22 ± 2.07 mm for lower posterior length (LPL). The UCM, UMW, and LMW of Muong were significantly wider in males, but narrower in females compared with other ethnic groups. The Kinh, Tay and Thai groups had no significant differences between genders in all dimensions, but these sizes were significantly larger in males than females of Muong group. Conclusions: This study presents the means of dental arch dimensions in 7 year-old Vietnamese children, and there is no statistical differences in these dimensions between genders of almost studied groups, except Muong group. Ethnic differences are observed only in UCW, UMW and LMW of Muong vs other groups. Furthermore, Vietnamese children have dental arch width similar to the African and Caucasian.

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The higher prevalence of developmental defects of enamel in the dioxin-affected region than non-dioxin-affected region: result from a cross-sectional study in Vietnam

Cited by 11 publications

References 12 publications

Effects of Polychlorinated Dibenzo-p-dioxins, Polychlorinated Dibenzofurans, and Dioxin-like PCBs on Teeth and Bones in Animals and Humans

Effects of Polychlorinated Dibenzo-p-dioxins, Polychlorinated Dibenzofurans, and Dioxin-like PCBs on Teeth and Bones in Animals and Humans

Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review

The dental arch dimensions in Vietnamese children at 7 years of age, and their variation by gender and ethnicity

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