The high-strength and toughness Janus bionic periosteum matching bone development and growth in children

Zhang, Zhiqiang; Bao, Luhan; Qian, Chuang; Furtado, Meison; Li, Haodong; Guo, Shangyu; Zheng, Yiming; Fu, Dong; Dong, Kuiran; Cui, Wenguo; Wang, Dahui

doi:10.1016/j.compositesb.2023.110642

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…The strength of the nHA/SF sample was lower than that of the porcine femoral periosteum (16.93 MPa) . However, since the artificial periosteum is not a load-bearing tissue, mechanical strength is not required and a certain tensile strength is required.…”

Section: Resultsmentioning

confidence: 93%

“…The strength of the nHA/SF sample was lower than that of the porcine femoral periosteum (16.93 MPa). 44 However, since the artificial periosteum is not a load-bearing tissue, mechanical strength is not required and a certain tensile strength is required. Compared with mechanical properties, the degradation properties and factor release profile are more critical to the function of the artificial periosteum.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Dual Factor-Loaded Artificial Periosteum Accelerates Bone Regeneration

Yao,

Liang,

Zeng

et al. 2024

ACS Biomater. Sci. Eng.

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In the clinic, inactivation of osteosarcoma using microwave ablation would damage the periosteum, resulting in frequent postoperative complications. Therefore, the development of an artificial periosteum is crucial for postoperative healing. In this study, we prepared an artificial periosteum using silk fibroin (SF) loaded with stromal cell-derived factor-1α (SDF-1α) and calcitonin gene-related peptide (CGRP) to accelerate bone remodeling after the microwave ablation of osteosarcoma. The prepared artificial periosteum showed a sustained release of SDF-1α and CGRP after 14 days of immersion. In vitro culture of rat periosteal stem cells (rPDSCs) demonstrated that the artificial periosteum is favorable for cell recruitment, the activity of alkaline phosphatase, and bone-related gene expression. Furthermore, the artificial periosteum improved the tube formation and angiogenesis-related gene expression of human umbilical vein endothelial cells (HUVECs). In an animal study, the periosteum in the femur of a rabbit was inactivated through microwave ablation and then removed. The damaged periosteum was replaced with the as-prepared artificial periosteum and favored bone regeneration. In all, the designed dual-factor-loaded artificial periosteum is a promising strategy to replace the damaged periosteum in the therapy of osteosarcoma for a better bone-rebuilding process.

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Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%