The high rate of familial lichen sclerosus suggests a genetic contribution: an observational cohort study

Шерман, В. Д.; McPherson, Tess; Baldo, Maha; Salim, A.; Xh, Gao; Wojnarowska, Fenella

doi:10.1111/j.1468-3083.2010.03572.x

Cited by 138 publications

(108 citation statements)

References 30 publications

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“…A genetic predisposition was shown in an observational cohort study of 1052 women with VLS where 12% had a family history of LS [11]. HLA-DR and DQ antigens or their haplotypes appear to be involved in susceptibility or resistance to VLS.…”

Section: Aetiologymentioning

confidence: 95%

Vulvar dermatosis

Moyal‐Barracco¹,

Wendling²

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

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Vulvar dermatoses are inflammatory conditions responsible for chronic or recurrent itching and soreness. The lesions are either circumscribed to the vulva or associated with extragenital localizations which may help to assess the diagnosis. They should be differentiated from infectious or neoplastic diseases which may have clinical similarities. As opposed to the majority of all dermatoses that have a benign and regular course, lichen sclerosus or lichen planus could exceptionally foster the occurrence of an epithelial cancer precursor which may evolve to squamous cell carcinoma. Topical corticosteroids are the mainstay treatment of vulvar dermatosis. We do not know if the treatment of vulvar lichen sclerosus and vulvar lichen planus prevents squamous cell carcinoma.

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Section: Aetiologymentioning

confidence: 95%

Vulvar dermatosis

Moyal‐Barracco¹,

Wendling²

2014

Best Practice & Research Clinical Obstetrics & Gynaecol

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“…Sherman et al [10] reported that patients with a positive familial history were more likely to have other associated autoimmune diseases as well as develop vulvar cancer. In that series, a positive familial history was positive in 12% of patients; in the present one it was 6%.…”

Section: Discussionmentioning

confidence: 99%

What Differentiates Symptomatic from Asymptomatic Women with Lichen Sclerosus?

Vieira‐Baptista

Lima-Silva

Cavaco-Gomes

et al. 2014

Gynecol Obstet Invest

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Aims: To investigate the differences between symptomatic and asymptomatic women with vulvarlichen sclerosus (LS). Methods: Data on file concerning 228 LS patients was retrospectively reviewed. Results: Most patients were symptomatic (193/228; 85%). Worsening of symptoms related to specific food intake was experienced by 26% (48/182) and pork was the most frequently cited (25/48; 52%); worsening at night was reported by 47% (87/185). Being over 50 years at the time of diagnosis or being menopausal were associated with being symptomatic (RR = 2.47, 95% CI: 1.15-5.29 and 6.55, 2.05-20.91, respectively). The same was true for urinary incontinence (UI) (5.23, 1.78-15.42), the use of absorbents (without UI) (3.59, 1.05-12.34) and dyspareunia (5.28, 1.64-17.0). All patients with a family history of LS were symptomatic. There was no association with hormonal factors or specific vulvar anatomical changes. Conclusions: Pork consumption may be involved in the worsening of symptoms. UI and the use of absorbents are more commonly present in symptomatic LS patients. Dietary changes and correction of UI might be useful in the control of LS symptoms.

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“…9 Genetic factors are implicated, and cases of familial LS have been reported. 10 Immunogenetic studies have demonstrated a significant association with HLA class II antigen DQ7 and DRB1*12. 11,12 LS has a tremendous impact on the quality of life by interfering with function (particularly sexual function) and self-image, and the resultant distress and anxiety are immediately apparent.…”

mentioning

confidence: 98%