The high prolificacy of D’man sheep is associated with the segregation of the FecLL mutation in the B4GALNT2 gene

Jemaa, Slim Ben; Ruesche, Julien; Sarry, Julien; Woloszyn, Florent; Lassoued, N.; Fabre, Stéphane

doi:10.1111/rda.13391

Cited by 15 publications

(7 citation statements)

References 21 publications

(44 reference statements)

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“…It can be assumed that the D'man and the Blanche de Montagne, being small sized breeds 10 , were crossed with the biggest Sardi and Timahdite individuals to increase their meat production. Otherwise, the D'man being well known for its high prolificacy 30 , was crossed to Sardi, Timahdite and Blanche de Montagne breeds to improve their reproductive characteristics.…”

Section: Discussionmentioning

confidence: 99%

The origin of sheep settlement in Western Mediterranean

Kandoussi

Boujenane

Auger

et al. 2020

Sci Rep

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The arrival of Neolithic culture in North Africa, especially domestic animals has been essentially documented from archaeological records. As the data relative to sheep are scarce, we studied the genetic relationship between Moroccan sheep breeds and Mediterranean ones using the sequencing of 628 bp of the mitochondrial DNA control region in 193 Moroccan individuals, belonging to six breeds, and 652 sequences from other breeds in Europe and Middle East. Through Network analysis and an original phylogenetically derived method, the connection proportions of each Moroccan breed to foreign ones were estimated, highlighting the strong links between Moroccan and Iberian breeds. The first founders of Moroccan sheep population were issued at 79% from Iberia and 21% from a territory between Middle East and Africa. Their calculated expansion times were respectively 7,100 and 8,600 years B.P. This suggests that Neolithization was introduced by a double influence, from Iberia and from another route, maybe Oriental or Sub-Saharan. The consequence of the environmental changes encountered by founders from Iberia was tested using different neutrality tests. There are significant selection signatures at the level of Moroccan and European breeds settled in elevated altitudes, and an erosion of nucleotide diversity in Moroccan breeds living in arid areas.

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Section: Discussionmentioning

confidence: 99%

The origin of sheep settlement in Western Mediterranean

Kandoussi

Boujenane

Auger

et al. 2020

Sci Rep

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“…As described for other prolific alleles, such as FecB B , FecX G , FecG H , FecX Gr , and FecL L , a given mutation can segregate in several sheep populations (Davis et al, 2002;Mullen et al, 2013;Chantepie et al, 2018;Ben Jemaa et al, 2019). We have tested the FecX N allele presence in a diversity of 26 sheep breeds representing 725 animals (Rochus et al, 2018).…”

Section: Characterization Of the Mutationmentioning

confidence: 99%

Genome-Wide Identification of a Regulatory Mutation in BMP15 Controlling Prolificacy in Sheep

et al. 2020

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The search for the genetic determinism of prolificacy variability in sheep has evidenced several major mutations in genes playing a crucial role in the control of ovulation rate. In the Noire du Velay (NV) sheep population, a recent genetic study has evidenced the segregation of such a mutation named FecL L . However, based on litter size (LS) records of FecL L non-carrier ewes, the segregation of a second prolificacy major mutation was suspected in this population. In order to identify this mutation, we have combined a case/control genome-wide association study with ovine 50k SNP chip genotyping, whole genome sequencing, and functional analyses. A new single nucleotide polymorphism (OARX:50977717T > A, NC_019484) located on the X chromosome upstream of the BMP15 gene was evidenced to be highly associated with the prolificacy variability (P = 1.93E-11). The variant allele was called FecX N and shown to segregate also in the Blanche du Massif Central (BMC) sheep population. In both NV and BMC, the FecX N allele frequency was estimated close to 0.10, and its effect on LS was estimated at +0.20 lamb per lambing at the heterozygous state. Homozygous FecX N carrier ewes were fertile with increased prolificacy in contrast to numerous mutations affecting BMP15. At the molecular level, FecX N was shown to decrease BMP15 promoter activity and supposed to impact BMP15 expression in the oocyte. This regulatory action was proposed as the causal mechanism for the FecX N mutation to control ovulation rate and prolificacy in sheep.

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“…This could be due to the genes for high prolificacy transmitted by the D rams to crossbred ewes, depending on whether or not the rams used carried these genes. Ben Jemaa et al (2019) reported that the high prolificacy of the D breed is due to the segregation of a prolificacy While the OD breed is characterized by a large body size capable of multiple gestations but low prolificacy, the D breed is known as being light in weight but prolific. These two breeds therefore complement each other in terms of zootechnical traits and can be crossed.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Évaluation des performances reproductives et productives d’un croisement génétique alternatif entre deux races ovines locales, Ouled Djellal et D’man

Sebkhi,

Adaouri,

Triki

et al. 2024

Rev. Elev. Med. Vet. Pays Trop.

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L’objectif de cette étude était d’évaluer l’effet du croisement alternatif sur les performances reproductives et la productivité des ovins. Deux races ovines indigènes algériennes ont été utilisées : Ouled Djellal (OD), connue pour ses qualités exceptionnelles de production de viande, et D’man (D), connue pour ses qualités exceptionnelles de reproduction. Au total, 288 brebis (tous génotypes confondus) ont été utilisées, dont 130 brebis OD de race pure constituant le troupeau de base de la première génération (G1), 71 brebis croisées (50 % de sang OD et 50 % de sang D) de la deuxième génération (G2), et 87 brebis croisées (75 % de sang OD et 25 % de sang D) de la troisième génération (G3). L’effet bélier a été utilisé pour synchroniser les chaleurs en lutte naturelle en lot. Nos résultats montrent une amélioration de la fécondité (fertilité × prolificité) des brebis des première, deuxième et troisième générations par rapport à la valeur standard (95 %) des brebis de race pure OD (G1 : 97,69 ± 66,43 % ; G2 : 122,54 ± 53,98 % ; G3 : 114,94 ± 58,13 %). Il y a également eu une amélioration de la productivité numérique et pondérale au sevrage (90 jours) par rapport aux valeurs précédemment rapportées pour les brebis OD élevées en Algérie. Pour la productivité numérique, les valeurs étaient de 83,85 ± 62,01 % à G1, 121,13 ± 53,23 % à G2, et 100 ± 54,98 % à G3 (contre 73 % rapportés dans la littérature) ; pour la productivité pondérale, les valeurs étaient de 15,29 ± 9,41 kg à G1, 24,56 ± 9,01 kg à G2, et 17,15 ± 7,67 kg à G3 (contre 10,55 kg rapportés dans la littérature). En conclusion, la race D, qui présente un potentiel reproductif exceptionnel, pourrait être utilisée en croisement pour augmenter la productivité des systèmes d’élevage ovin fonctionnant dans les conditions locales dans les zones favorables à la production de viande. Elle pourrait également être utilisée pour créer une race synthétique en la croisant alternativement avec la race ovine locale OD.

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The high prolificacy of D’man sheep is associated with the segregation of the FecL^L mutation in the B4GALNT2 gene

Cited by 15 publications

References 21 publications

The origin of sheep settlement in Western Mediterranean

The origin of sheep settlement in Western Mediterranean

Genome-Wide Identification of a Regulatory Mutation in BMP15 Controlling Prolificacy in Sheep

Évaluation des performances reproductives et productives d’un croisement génétique alternatif entre deux races ovines locales, Ouled Djellal et D’man

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