The High Prevalence of Vitamin D Deficiency and Its Related Maternal Factors in Pregnant Women in Beijing

Song, Shujun; Zhou, Ling; Si, Shihui; Liu, Junli; Zhou, Jianan; Feng, Kai; Wu, Jie; Zhang, Wenying

doi:10.1371/journal.pone.0085081

Cited by 61 publications

(54 citation statements)

References 45 publications

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“…Similar results were obtained by several other investigators [12,13]. "In a study including 133 women with recurrent pregnancy loss, Ota et al showed that 63 out of 133 women (47.4%) had Vitamin D deficiency [19]."…”

Section: Discussionsupporting

confidence: 81%

“…Evidence about the role of Vitamin D in human reproduction has been proved in a number of researchers [11]. Globally, vitamin deficiency is a frequent problem among women at the age of childbearing [12,13] among obstetric complications that have been reported to be associated with Vitamin Deficiency are gestational diabetes [14], pre-eclampsia [15] impaired intrauterine growth [16], and bacterial vaginosis [17]. Despite that, the association between poor Vitamin D status and spontaneous early pregnancy loss is less well defined.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Maternal Serum Vitamin D and Early Pregnancy Spontaneous Abortion in Iraqi Women

Mohammed

Alqani

2018

Asian J Pharm Clin Res

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Background: Spontaneous pregnancy loss is seen in approximately 10-15% of clinically observed pregnancies.Objective: This study was aimed to estimate the Vitamin D serum concentration in a cohort of women with a history of recurrent spontaneous abortion. Methods:The current cross-sectional study was conducted at Al-Diwaniya maternity and child teaching hospital, Al-Diwaniya province, Iraq. Data collection, lab work, and procedures related to the study extended from August 2016 to August 2017. The study enrolled 42 women of childbearing age who have a history of spontaneous early pregnancy loss. From each woman, a venous sample was obtained and sent to a lab to assess serum Vitamin D concentrations using standard routine biochemical methods.Results: Assessment of mean maternal serum Vitamin D concentration revealed that the mean was 21.48±11.82 (ng/ml) and the range was from 5 to 50 (ng/ml). The number of women with low serum Vitamin D (<20 ng/ml) was 25 (approximately 60%), the results also revealed a highly negative correlation was obtained between number of abortions and maternal serum Vitamin D (r=−0.717, p<0.001) and that the value or R 2 was 0.514 which indicated that the level of Vitamin D alone can act as an independent predictor to explain 51.4% of spontaneous abortions in the participating women. Conclusion:Vitamin D level is a strong predictor of pregnancy loss in early pregnancy, and that correction of Vitamin D status among Iraqi pregnant ladies may substantially reduce the frequency of spontaneous abortion.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Association Between Maternal Serum Vitamin D and Early Pregnancy Spontaneous Abortion in Iraqi Women

Mohammed

Alqani

2018

Asian J Pharm Clin Res

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“…Although 23 % of Auckland SCOPE participants were vitamin D deficient (25-hydroxyvitamin D <50 nmol/l), half to more than 90 % of pregnant women have been found to be deficient in previous studies (20)(21)(22) . The SCOPE Auckland cohort may be more vitamin D replete in comparison with the obstetric Auckland population and the wider New Zealand population.…”

Section: Discussionmentioning

confidence: 90%

The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort

et al. 2016

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Type of publicationArticle (peer-reviewed)Link to publisher's version http://dx.doi.org/10.1017/S0007114516003202Access to the full text of the published version may require a subscription. Rights © The Authors 2016Embargo information Access to this article is restricted until 12 months after publication by the request of the publisher Abstract Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes in a large, prospective pregnancy cohort. 25-Hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks of gestation from 1710 New Zealand women participating in a large, observational study. Associations between vitamin D status and pre-eclampsia, preterm birth, small for gestational age (SGA) and gestational diabetes were investigated. The mean 25-hydroxyvitamin D concentration was 72·9 nmol/l. In all, 23 % had 25-hydroxyvitamin D concentrations <50 nmol/l, and 5 % of participants had concentrations <25 nmol/l. Women with 25-hydroxyvitamin D concentrations <75 nmol/l at 15 weeks of gestation were more likely to develop gestational diabetes mellitus than those with concentrations >75 nmol/l (OR 2·3; 95 % CI 1·1, 5·1). However, this effect was not significant when adjustments were made for BMI and ethnicity (OR 1·8; 95 % CI 0·8, 4·2). 25-Hydroxyvitamin D concentration at 15 weeks was not associated with development of pre-eclampsia, spontaneous preterm birth or SGA infants. Pregnancy complications were low in this largely vitamin D-replete population.Key words: Vitamin D: Gestational diabetes mellitus: Pre-eclampsia Much progress has been made in the screening, diagnosis and management of important pregnancy disorders, but little progress has been made in the prevention of such disorders. Preeclampsia remains the second most common cause of maternal death worldwide (1) . Prematurity, mostly due to spontaneous preterm birth, is the leading cause of death among infants worldwide (2) . This is followed by growth restriction in term infants (3) . Furthermore, infants born preterm or with low birth weight have an increased risk of CVD and metabolic diseases later in life, the leading cause of death in adulthood (4) . The incidence of gestational diabetes mellitus (GDM) is increasing rapidly worldwide (5) and is associated with lifelong risks of metabolic disease in both mother and baby (6,7) . An association between low vitamin D and adverse pregnancy outcomes was first identified in the early 2000s (8) ; consequently, vitamin D has been postulated as a possible intervention strategy to reduce pregnancy complications. A recent meta-analysis found that low vitamin D, defined variably by the authors of included studies, was associated with an increased likelihood of pre-eclampsia (OR 1·79; 95 % CI 1·25, 2·58), small-for-gestational age (SGA) babies (OR 1·...

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“…Non-adherence to medication and advice can be due to lack of cultural competence from a care-giver perspective leading to that clinical needs are missed [14] such as the deficient levels of vitamin D (25-OHD) in pregnant non-Western women living in Europe [15–17], in adolescent girls in England [18], and in post-partum mothers [15]. Lack of vitamin D also occurs in high frequency in native populations of women in Beijing [19] and Denmark [20] while Swedish women in general practice seldom have levels below 25 nmol/L [21]. Notably, no clinical data were provided in any of the above mentioned studies.…”

Section: Discussionmentioning

confidence: 99%

Long-term adherence and effects on grip strength and upper leg performance of prescribed supplemental vitamin D in pregnant and recently pregnant women of Somali and Swedish birth with 25-hydroxyvitamin D deficiency: a before-and-after treatment study

Kalliokoski

Rodhe

Bergqvist

et al. 2016

BMC Pregnancy Childbirth

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BackgroundMuscular weakness and severe vitamin D deficiency is prevalent in Somali (veiled) pregnant women, Sweden. The study aims here were to explore adherence to prescribed supplemental vitamin D in new mothers with vitamin D deficiency and its effects on grip strength and upper leg performance in Somali (target group TG) and Swedish women (reference group RG) from spring through winter.MethodsA before- and after study was designed. A cross-sectional sample of women in antenatal care with serum 25-OHD ≤50 nmol/L were prescribed one or two tablets daily (800 or 1600 IU vitamin D3 with calcium) for 10 months. Reminders were made by Somali nurses (TG) or Swedish doctors (RG). Baseline and 10 month measurements of plasma nmol/L 25-OHD, maximal grip strength held for 10 s (Newton, N) and ability to squat (yes;no) were done. Total tablet intake (n) was calculated. Outcome variables were changes from baseline in grip strength and ability to squat. Predicting variables for change in grip strength and ability to squat were calculated using linear and binary regression in final models. Undetectable 25-OHD values (<10 nmol/L) were replaced with ‘9’ in statistic calculations.ResultsSeventy-one women (46 TG, 1/3 with undetectable baseline 25-OHD; 25 RG) participated. At the 10-month follow up, 17% TG and 8% RG women reported having refrained from supplement. Mean 25-OHD increased 16 to 49 nmol/L (TG) and 39 nmol/L to 67 nmol/L (RG), (both p < 0.001). Grip strength had improved from 153 to 188 N (TG) (p < 0.001) and from 257 to 297 N (RG) (p = 0.003) and inability to squat had decreased in TG (35 to 9, p < 0.001). Intake of number of tablets predicted increased grip strength (B 0.067, 95%CI 0.008–0.127, p = 0.027). One tablet daily (>300 in total) predicted improved ability to squat (OR 16; 95% CI 1.8–144.6).ConclusionsAdherence to supplemental vitamin D and calcium should be encouraged as an even moderate intake was associated to improved grip strength and upper leg performance, which was particularly useful for the women with severe 25-OHD deficiency and poor physical performance at baseline.Trial registrationClinicalTrials.gov Identifier: NCT02922803. Date of registration: September 28, 2016.

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The High Prevalence of Vitamin D Deficiency and Its Related Maternal Factors in Pregnant Women in Beijing

Cited by 61 publications

References 45 publications

Association Between Maternal Serum Vitamin D and Early Pregnancy Spontaneous Abortion in Iraqi Women

Association Between Maternal Serum Vitamin D and Early Pregnancy Spontaneous Abortion in Iraqi Women

The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort

Long-term adherence and effects on grip strength and upper leg performance of prescribed supplemental vitamin D in pregnant and recently pregnant women of Somali and Swedish birth with 25-hydroxyvitamin D deficiency: a before-and-after treatment study

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