The high potency of ME-5343 to aphids is due to a unique mechanism of action

Leichter, Cheryl A.; Thompson, Nathan; Johnson, Bruce; Scott, Jeffrey G.

doi:10.1016/j.pestbp.2013.06.009

Cited by 52 publications

(32 citation statements)

References 26 publications

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“…It is reported to be active against sucking insects, such as aphids, thrips and psyllids. The molecule was based on the natural product pyripyropene A, which was isolated from the fungi Aspergillus fumigatus . Kandasamy et al.…”

Section: Introductionmentioning

confidence: 99%

Determination and dissipation of afidopyropen and its metabolite in wheat and soil using QuEChERS–UHPLC–MS/MS

Chen

Guo²,

Liu

et al. 2018

J of Separation Science

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The dissipations of afidopyropen and its metabolite in wheat plant and soil were determined using a quick, easy, cheap, effective, rugged, and safe method with ultra-high performance liquid chromatography and tandem mass spectrometry under a field ecosystem. The limits of quantification were estimated for both target compounds as 0.001 mg/kg. The recoveries of afidopyropen and its metabolite ranged from 94 to 114% (soil), 90 to 109% (wheat seed) and 81 to 91% (wheat straw) at levels of 0.001, 0.01, 0.1, and 2.0 mg/kg with relative standard deviations ≤7%. The results of the residual dynamics experiments showed that afidopyropen dissipated rapidly in wheat plant and soil. Its metabolite initially showed a tendency of rapid increase followed by a decrease in wheat plant but could not be detected in soil. The data showed that the first + first-order model was more suitable for describing the decline of afidopyropen in wheat and soil. The half-lives of afidopyropen in wheat plant and soil were 1.65 and 1.21 days, respectively.

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Section: Introductionmentioning

confidence: 99%

Determination and dissipation of afidopyropen and its metabolite in wheat and soil using QuEChERS–UHPLC–MS/MS

Chen

Guo²,

Liu

et al. 2018

J of Separation Science

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“…The relative lack of toxicity of afidopyropen to natural enemies is not surprising considering that this insecticide has shown little to no toxicity to a range of other taxa (i.e. Blattodea, Diptera and Coleoptera) . Similarly, flonicamid was not toxic to H. convergens adults and showed no to moderate toxicity to O. insidiosus adults, and was not toxic to A. certus .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of afidopyropen against soybean aphid (Hemiptera: Aphididae) and toxicity to natural enemies

Koch

Queiroz

Aita

et al. 2019

Pest Management Science

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BACKGROUND Soybean aphid, Aphis glycines (Hemiptera: Aphididae), remains the most significant soybean insect pest in the North Central Region of the USA. The sustainability of reliance on only a few insecticide groups for this pest is questionable. We evaluate afidopyropen, a novel pyropene insecticide (Group 9D), for efficacy against A. glycines in field and greenhouse experiments and toxicity to common natural enemies in laboratory experiments. RESULTS Across 4 site‐years of field experiments and a greenhouse experiment, afidopyropen reduced A. glycines populations similar to commonly used broad‐spectrum [i.e. lambda‐cyhalothrin (Group 3A) and chlorpyrifos (Group 1B)] insecticides and potential selective insecticides [i.e. sulfoxaflor (Group 4C) and flupyradifurone (Group 4D)]. In the greenhouse, however, A. glycines mortality was delayed slightly for afidopyropen compared to the other insecticides. In laboratory experiments with natural enemies of A. glycines, afidopyropen was not toxic to adult or third instar Hippodamia convergens (Coleoptera: Coccinellidae) or adult Orius insidiosus (Hemiptera: Anthocoridae), and was only moderately toxic to Aphelinus certus (Hymenoptera: Aphelinidae). CONCLUSION Afidopyropen is effective against A. glycines and relatively non‐toxic to natural enemies, and appears to be an effective option for integrated pest management and insecticide resistance management programs for A. glycines. © 2019 Society of Chemical Industry

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“…Afidopyropen is a new potent and specific modulator of insect transient receptor potential vanilloid (TRPV) cation channels, exhibiting unique binding (Kandasamy et al 2017;Nilius and Owsianik 2011). It is derived from natural products (Jeschke 2017;Leichter et al 2013). The insecticidal activity of chordotonal organ TRPV channel modulators is likely related to species selectivity at the target level and the importance of chordotonal organs for insect survival.…”

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confidence: 99%

“…Their mode of action involves stimulating heterologously expressed transient receptor potential channels that act by targeting nanchung (NAN) and inactive (INA) proteins (Kandasamy et al 2017). Afidopyropen is a semi-synthetic analog of pyropropen, and was developed to target sap-feeding insects such as the pea aphid Acyrthosiphon pisum Harris (Hemiptera: Aphididae) by causing mortality through starvation and desiccation (Gerwick and Sparks 2014;Leichter et al 2013). In contrast, afidopyropen is practically nontoxic to other species-including German cockroach Blatella germanica (Linnaeus) (Blattodea: Blattellidae), yellow fever mosquito Aedes aegypti (Linnaeus) (Diptera: Culicidae), Colorado potato beetle Leptinotarsa decemlineata (Say) (Coleoptera: Chrysomelidae), red flour beetle Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae), house fly Musca domestica (Linnaeus) (Diptera: Muscidae), and fireflies Photuris spp.…”

mentioning

confidence: 99%

“…In contrast, afidopyropen is practically nontoxic to other species-including German cockroach Blatella germanica (Linnaeus) (Blattodea: Blattellidae), yellow fever mosquito Aedes aegypti (Linnaeus) (Diptera: Culicidae), Colorado potato beetle Leptinotarsa decemlineata (Say) (Coleoptera: Chrysomelidae), red flour beetle Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae), house fly Musca domestica (Linnaeus) (Diptera: Muscidae), and fireflies Photuris spp. (Coleoptera: Lampyridae)-despite the presence of NAN and IAV transcripts (Leichter et al 2013).…”

mentioning

confidence: 99%

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Susceptibility of Asian citrus psyllid, Diaphorina citri (Hemiptera: Liviidae), to the insecticide afidopyropen: a new and potent modulator of insect transient receptor potential channels

2018

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A relatively new insecticide chemistry for controlling sucking insects, afidopyropen, was investigated for toxicity against Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae). We evaluated the mortality of D. citri eggs, nymphs, and adults treated with afidopyropen using both laboratory-reared and field populations. We also quantified the effects of sublethal doses of afidopyropen on D. citri feeding, host choice selection, and fecundity. For laboratory susceptible adults, the contact LC 50 , topical application LD 50 , and leaf dip LC 50 were 2.13, 2.00, and 3.08 ng/µL, respectively. For adults collected from a commercially managed citrus grove in Florida, the contact LC 50 , topical application LD 50 , and leaf dip LC 50 were 1.37, 1.92, and 4.89 ng/µL, respectively. Egg hatch was significantly reduced following exposure to afidopyropen at 100 ng/µL. Furthermore, afidopyropen reduced D. citri nymph survival and adult emergence at concentrations ranging between 0.01 and 100 ng/µL. Diaphorina citri adult feeding decreased on citrus leaves treated with afidopyropen in a concentration-dependent manner as measured indirectly by honeydew excretion, and appeared almost completely inhibited after treatment with 10 and 100 ng/µL solutions of afidopyropen. In choice tests, significantly fewer D. citri adults settled on afidopyropen-treated plants than on control plants at 24, 48, and 72 h after release, with no differences in settling between males and females. Afidopyropen reduced the fecundity of D. citri in a concentration-dependent manner. Collectively, the results suggest that afidopyropen could contribute to the integrated management of D. citri and may therefore be useful in rotational programs to improve resistance management.

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The high potency of ME-5343 to aphids is due to a unique mechanism of action

Cited by 52 publications

References 26 publications

Determination and dissipation of afidopyropen and its metabolite in wheat and soil using QuEChERS–UHPLC–MS/MS

Determination and dissipation of afidopyropen and its metabolite in wheat and soil using QuEChERS–UHPLC–MS/MS

Efficacy of afidopyropen against soybean aphid (Hemiptera: Aphididae) and toxicity to natural enemies

Susceptibility of Asian citrus psyllid, Diaphorina citri (Hemiptera: Liviidae), to the insecticide afidopyropen: a new and potent modulator of insect transient receptor potential channels

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