2018
DOI: 10.1038/s41598-018-19666-7
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The high molecular weight dipeptidyl peptidase IV Pol d 3 is a major allergen of Polistes dominula venom

Abstract: Hymenoptera venom allergy can cause severe anaphylaxis in untreated patients. Polistes dominula is an important elicitor of venom allergy in Southern Europe as well as in the United States. Due to its increased spreading to more moderate climate zones, Polistes venom allergy is likely to gain importance also in these areas. So far, only few allergens of Polistes dominula venom were identified as basis for component-resolved diagnostics. Therefore, this study aimed to broaden the available panel of important Po… Show more

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Cited by 34 publications
(53 citation statements)
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“…The most common vespid stings leading to anaphylactic reactions involve the Polistes dominula (PD) and Ves­pula ( VV) species in southern Europe, and cross-reactions between them are well documented [1-3]. However, current routinely performed in vitro and in vivo diagnostics are not able to clinically distinguish between irrelevant cross-reactivity and real double sensitization to vespid venom.…”
mentioning
confidence: 99%
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“…The most common vespid stings leading to anaphylactic reactions involve the Polistes dominula (PD) and Ves­pula ( VV) species in southern Europe, and cross-reactions between them are well documented [1-3]. However, current routinely performed in vitro and in vivo diagnostics are not able to clinically distinguish between irrelevant cross-reactivity and real double sensitization to vespid venom.…”
mentioning
confidence: 99%
“…1). Molecular allergy research and development will likely help in sequencing new species-specific antigens for vespids, especially PD, whose antigen 1 (phospholipase) is not currently available for routinely diagnostic use; this would markedly increase the accuracy, making a Ves v 1/Pol d 1 comparison possible [1]. For the time being, the recombinant allergens currently in use, i.e., Ves v 5, Pol d 5, and Ves v 1, do not provide sufficient accuracy.…”
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confidence: 99%
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“…Its putative function in HBV is the processing and activation of the membrane‐toxic peptide melittin. The role of Api m 5 as major allergen of HBV was confirmed by its pronounced sIgE reactivity and the potent activation of basophils from HBV‐allergic patients …”
Section: Commentarymentioning
confidence: 92%
“…Subsequently, the Api m 5 homologues from Vespula vulgaris and Polistes dominula venom Ves v 3 and Pol d 3 were identified and characterized . Due to the extent of homology, both major allergens are protected by the same patent.…”
Section: Commentarymentioning
confidence: 99%