The High Fat Diet Impacts the Plasticity between Fresh and Aged Neutrophils
Andrea Baragetti,
Giuseppe Danilo Norata
Abstract:Metabolic alterations induced by unhealthy lifestyles, including obesity and insulin resistance are often associated with increased innate immune response and chronic inflammation. Cholesterol has been identified as a key metabolite driving the activation of the inflammasome and the “epigenetic memory” in long-term living hematopoietic stem cells.
In addition to these mechanisms, the physiological aging of short-living neutrophils is a relevant modifier of their immune competency, as while they egress from … Show more
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