The High-Energy Proton Beam as a Neurosurgical Tool

Larsson, B.; Leksell, L; Rexed, Bror; Sourander, Patrick; Mair, W.; Andersson, B.

doi:10.1038/1821222a0

Cited by 245 publications

(66 citation statements)

References 1 publication

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“…MeV protons at the Harvard Cyclotron Laboratory (HCL) 91 to treat more than 4000 patients. 5 5 • 92 -97 •From 1957 to 1968, the 185-MeV protons from the 230-cm synchrocyclotron at the Gustaf Werner Institute in Uppsala, Sweden was used to treat a limited number of patients with stereotactic radiosurgery of the brain 98 and for the treatment of cancer. 99 • 101 They have upgraded a 200-MeV .…”

Section: Ibl On-going Proton and Helium-ion Trialsmentioning

confidence: 99%

Instrumentation for treatment of cancer using proton and light-ion beams

Chu

Ludewigt

Renner

1993

Review of Scientific Instruments

283

186

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Clinical trials using accelerated heavy charged-particle beams for treating cancer and other diseases have been performed for nearly four decades. Recently there have been worldwide efforts to construct hospital-based medically dedicated proton or light-ion accelerator facilities. To make such accelerated heavy charged-particle beams clinically useful, specialized instruments must be developed to modify the physical characteristics of the particle beams in order to optimize their biological and clinical effects. This article reviews the beam modifying devices and associated dosimetric equipment developed specifically for controlling and monitoring the clinical beams.

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Section: Ibl On-going Proton and Helium-ion Trialsmentioning

confidence: 99%

Instrumentation for treatment of cancer using proton and light-ion beams

Chu

Ludewigt

Renner

1993

Review of Scientific Instruments

283

186

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“…More than 50 years ago, he investigated combining stereotactic surgery techniques with external beam irradiation [4] . In 1956, about the same time that similar work began in the USA, Larsson and Leksell initiated proton radiosurgery in Uppsala, Sweden [5] . Some 12 years later, these two individuals led the development of Gammaknife cranial radiosurgery, and in 1972 Leksell and his son founded Elekta Instruments to manufacture this and other related devices.…”

Section: Stereotaxis and Radiotherapy Deliverymentioning

confidence: 99%

New Technologies in the Radiotherapy Clinic

Meyer¹,

Verhey²,

Xia

et al. 2007

IMRT, IGRT, SBRT - Advances in the Treatment Planning and Delivery of Radiotherapy

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What are the limitations to the accuracy of our current technologies in radiation oncology? The immobilization of the patient, definition of the target, motion of the target and localization of the target are the major concerns that must be addressed. Current approaches to meet these needs have brought new technical systems with greater precision and new clinical procedures with higher expectations of practice. This text offers discussions on these issues, including advances in intensitymodulated radiotherapy planning, clinical target definition for the major tumor sites, management of organ motion, target localization and image guidance systems, and the expanding applications of high-precision treatment with stereotactic body radiotherapy. The technologies of radiotherapy planning and delivery have undergone rapid change. While these changes have been welcomed and carefully nurtured for the benefit of the cancer patient, each change has carried with it a spectrum of new concerns about its appropriate application and efficient integration into radiotherapy practice. These technologies, and the clinical treatment programs that bring them into practical use, are the focus of this volume.These technical achievements are closely interrelated: one development gives opportunity for another, but often necessitates the creation of a third, and then redefines the use of several others. Understanding this evolving world of new technologies and their applications requires broad perspectives from different vantage points. This volume first takes the viewpoint of computerized treatment planning and delivery with intensity-modulated radiotherapy (IMRT), an elaboration of

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“…27 They also considered the LINAC as a potential radiation source. Ultimately, they constructed the Gamma Knife using cobalt radiation.…”

Section: Linear Accelerator Technology and Radiosurgerymentioning

confidence: 99%

“…30 Leksell began treating patients with this device in 1957, calling the technique "stralkniven" (ray knives). 11,27 Other investigators worked with particle beam radiosurgery systems at the University of California at Berkeley and in Boston. 23,33 Early radiosurgery researchers were aware of LINAC's potential in delivering targeted radiation.…”

Section: Linear Accelerator Technology and Radiosurgerymentioning

confidence: 99%

Stereotactic radiosurgery and the linear accelerator: accelerating electrons in neurosurgery

Rahman¹,

Murad²,

Bova³

et al. 2009

FOC

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The search for efficacious, minimally invasive neurosurgical treatment has led to the development of the operating microscope, endovascular treatment, and endoscopic surgery. One of the most minimally invasive and exciting discoveries is the use of targeted, high-dose radiation for neurosurgical disorders. Radiosurgery is truly minimally invasive, delivering therapeutic energy to an accurately defined target without an incision, and has been used to treat a wide variety of pathological conditions, including benign and malignant brain tumors, vascular lesions such as arteriovenous malformations, and pain syndromes such as trigeminal neuralgia. Over the last 50 years, a tremendous amount of knowledge has been garnered, both about target volume and radiation delivery. This review covers the intense study of these concepts and the development of linear accelerators to deliver stereotactic radiosurgery. The fascinating history of stereotactic neurosurgery is reviewed, and a detailed account is given of the development of linear accelerators and their subsequent modification for radiosurgery.

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The High-Energy Proton Beam as a Neurosurgical Tool

Cited by 245 publications

References 1 publication

Instrumentation for treatment of cancer using proton and light-ion beams

Instrumentation for treatment of cancer using proton and light-ion beams

New Technologies in the Radiotherapy Clinic

Stereotactic radiosurgery and the linear accelerator: accelerating electrons in neurosurgery

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