“…Upon gentle heating or vacuum drying of the harmine phenolate, the macromorphology of the crystal is preserved (Figure 5 The production of a porous API through the evaporation of solvent has been demonstrated previously for clozapine to which the porous structure increased the dissolution rate 5-fold. 36 Both carbamazepine and verapamil hydrochloride show no crystallisation or melting events at any ratio except an exotherm followed directly by and endotherm in the carbamazepine system at 10:1. Both systems display a Tg on both cooling and warming, which moves systematically towards lower temperatures with higher ratios.…”
Section: Thermal Analysis and Applicabilitymentioning
A new class of deep eutectic solvents are presented which exhibit all of the physical characteristics of classical deep eutectic solvents, with the exception that one of the components is volatile when exposed to the atmosphere at room temperature. This enables a premeditated, auto-destructive capability which can lead to novel crystalline identities. We demonstrate the effectiveness of this concept through the room-temperature crystallisation of a broad range of organic molecules, with a particular focus on pharmaceuticals, that possess a variety of functional groups and molecular complexity. Furthermore, we show how, through the simple altering of the eutectic composition, polymorphism in paracetamol can be controlled, enabling the elusive metastable form II to spontaneously crystallise at room temperature.Born from the class of solvents known as ionic liquids, the deep eutectic solvents (DESs), named from the Greek "εu" (eu = easy) and "τήξις" (teksis = melting), have been an increasingly well-researched class of solvents for the last two decades. They have been a boon to catalysis, extraction processes, electrochemistry, organic synthesis and in the creation of more efficient batteries and dye-sensitized solar cells. [1][2][3][4][5][6][7] Originally conceived as a greener and cheaper alternative to the more toxic and less environmentally friendly ionic liquids, 8,9 DESs Supporting Information Table S1 and Figures S1 -S21 Accession Codes CCDC 1879336 and CCDC 1879689 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.
“…Upon gentle heating or vacuum drying of the harmine phenolate, the macromorphology of the crystal is preserved (Figure 5 The production of a porous API through the evaporation of solvent has been demonstrated previously for clozapine to which the porous structure increased the dissolution rate 5-fold. 36 Both carbamazepine and verapamil hydrochloride show no crystallisation or melting events at any ratio except an exotherm followed directly by and endotherm in the carbamazepine system at 10:1. Both systems display a Tg on both cooling and warming, which moves systematically towards lower temperatures with higher ratios.…”
Section: Thermal Analysis and Applicabilitymentioning
A new class of deep eutectic solvents are presented which exhibit all of the physical characteristics of classical deep eutectic solvents, with the exception that one of the components is volatile when exposed to the atmosphere at room temperature. This enables a premeditated, auto-destructive capability which can lead to novel crystalline identities. We demonstrate the effectiveness of this concept through the room-temperature crystallisation of a broad range of organic molecules, with a particular focus on pharmaceuticals, that possess a variety of functional groups and molecular complexity. Furthermore, we show how, through the simple altering of the eutectic composition, polymorphism in paracetamol can be controlled, enabling the elusive metastable form II to spontaneously crystallise at room temperature.Born from the class of solvents known as ionic liquids, the deep eutectic solvents (DESs), named from the Greek "εu" (eu = easy) and "τήξις" (teksis = melting), have been an increasingly well-researched class of solvents for the last two decades. They have been a boon to catalysis, extraction processes, electrochemistry, organic synthesis and in the creation of more efficient batteries and dye-sensitized solar cells. [1][2][3][4][5][6][7] Originally conceived as a greener and cheaper alternative to the more toxic and less environmentally friendly ionic liquids, 8,9 DESs Supporting Information Table S1 and Figures S1 -S21 Accession Codes CCDC 1879336 and CCDC 1879689 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.
“…The kinetic and the thermodynamic parameters were derived using Equation 3published by Kashchiev et al 61 and used by the authors in the past. 14,42 𝐽(𝑆) = 𝐴 𝑆 exp ( -𝐵/𝑙𝑛 2 𝑆)…”
Section: Figure 6: (A) and (B) Plot Of 'Ln(j/s) Or Ln(j * /S)' Against (1/(t 3 Ln 2 S)) × 10 6 Which Illustrates The Dependence Of Nucleamentioning
confidence: 99%
“…This is consistent with their previous findings on the nucleation of clozapinemethanol solvate in the presence of MCC, confirming that the pre-exponential factor is the major contributing factor to heterogeneous nucleation. 42 Glycine and diglycine were selected as molecules of interest for this work. The reason for this is that glycine is the simplest and most studied amino acid, consisting of a non-heavy hydrogen side chain, which eliminates the need to consider the effect of the side chain of the amino acid when analysing the effect of the heterosurface.…”
Traditionally, the enhancement of nucleation rates in the presence of heterogeneous surfaces in crystallisation processes has been attributed to modification of the interfacial energy of the system according to the...
“…In the free base (Fillers & Hawkinson, 1982) this angle is 67.3 [unfortunately, the atomic coordinates retrieved from the CSD (Groom et al, 2016) have no s.u. values] and in the monohydrate (CSD refcode DEHBUP; the publication cited in the CSD could not be traced) and the methanol solvate (Verma et al, 2018), the corresponding angles are 63.4 and 56.1 , respectively. In the 1:1 salt formed with 3,5-dinitrobenzoic acid (II), this angle is 62.21 (11) (Kaur et al, 2015), fairly similar to the values of 60.97 (9) and 59.07 (16) in the 1:1 salts formed with maleic and 2-hydroxybenzoic acids, respectively (Kaur et al, 2015).…”
Section: Figurementioning
confidence: 99%
“…There are no hydrogen bonds in the structure of clozapine itself (Fillers & Hawkinson, 1982), but in the monohydrate (DEHBUP), a combination of one N-HÁ Á ÁO hydrogen bond and two O-HÁ Á ÁN hydrogen bonds links the components into a chain of rings. In the methanol solvate of clozapine (Verma et al, 2018), the components are linked by an O-HÁ Á ÁN hydrogen bond, but with no further aggregation. In the hydrogenmaleate and 2-hydroxybenzoate salts, multiple hydrogen bonds generate sheets and a three-dimensional supramolecular network, respectively (Kaur et al, 2015), while in the di(hydrobromide) salt, the ions are linked into chains by N-HÁ Á ÁBr hydrogen bonds (Fillers & Hawkinson, 1982).…”
In the title salt {systematic name: 4-[6-chloro-2,9-diazatricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaen-10-yl]-1-methylpiperazin-1-ium 3,5-dinitrobenzoate–3,5-dinitrobenzic acid (1/1)}, C18H20ClN4
+·C7H3N2O6
−·C7H4N2O6, there is a very short, asymmetric, O—H...O hydrogen bond [O...O = 2.453 (3) Å] within the anion. The oxygen atoms of one of the nitro groups of the anion are disordered over two sets of sites having occupancies of 0.56 (3) and 0.44 (3). The fused tricyclic portion of the cation adopts a butterfly conformation, with a dihedral angle of 45.59 (6)° between the planes of the two aryl rings. In the crystal, a combination of O—H...O, N—H...O and C—H...O hydrogen bonds links the component species into a three-dimensional framework. Comparisons are made with the structures of some related compounds.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.