The heterogeneity and complexity of skin surface lipids in human skin health and disease

Mijaljica, Dalibor; Townley, Joshua P.; Spada, Fabrizio; Harrison, Ian P.

doi:10.1016/j.plipres.2023.101264

Cited by 3 publications

(4 citation statements)

References 150 publications

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“…The Strat-M®, speci cally designed for skin penetration studies, consists of two layers of polyethersulfone in the outer layer, and a more diffusive polyole n layer in the bottom layer . In addition, it contains simulated skin lipids those found in the human stratum corneum (Mijaljica et al 2024;Uchida et al 2015). The Strat-M® can be applied as an inexpensive, stable and simple membrane in diffusion studies of active ingredients, excipients, and nished products for both topical and transdermal formulations.…”

Section: Discussionmentioning

confidence: 99%

An evaluation of collagen peptide for transdermal delivery using Strat-M ® membrane and excised mouse skin

Yan,

Dong,

Jiang

et al. 2024

Preprint

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In the field of medicine and cosmetics, transdermal experiments commonly used to evaluate the transdermal absorption of topical formulations. In this study, we applied Strat-M® membrane to study the in vitro transdermal properties of collagen peptide with different average molecular weight, and compared them with the transdermal absorption through excised mouse skin in vitro. The results showed that the transdermal rate of collagen peptide through Strat-M® and excised mouse skin increased linearly with time, and the different concentrations of collagen peptide solutions affected the final cumulative transmission. The cumulative transmission per unit area and transdermal rate of CP500 were both the highest among the four CPs. The cumulative transmission per unit area of collagen peptides through Strat-M® has a good correlation with that through excised mouse skin, R2 > 0.98. Strat-M® can replace the excised mouse skin in vitro to carry out the transdermal experiment of collagen peptide. Our results can be used to guide formulators in selecting vehicles in early development in the pharmaceutical, personal care and cosmetic industries.

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Section: Discussionmentioning

confidence: 99%

An evaluation of collagen peptide for transdermal delivery using Strat-M ® membrane and excised mouse skin

Yan,

Dong,

Jiang

et al. 2024

Preprint

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“…These amphipathic molecules consist of diverse sphingoid bases, N -acyl fatty acids, and polar head groups. They modulate multiple signaling pathways such as the cell cycle, senescence, and apoptosis through de novo synthesis or by hydrolyzing sphingomyelins. , With an increasing level of contaminants, barrier-promoting long-chain ceramide C20CER showed a negative linear trend after adjusting for other hair biocomponents and potential confounders. Other biocomponents did not exhibit a significant association with contaminants, possibly due to the small sample size.…”

Section: Discussionmentioning

confidence: 99%

“…39 Long-chain ceramides promote biological barrier function, while an increasing level of short-chain ceramides is associated with barrier damage. 40 Ceramides could thus induce changes in lipid metabolism by disrupting the cell membrane and promoting the retention of contaminants that associate with the displaced phospholipids. 35,37 We observed a significant overall negative association between the PFRs and biocomponents in hair.…”

Section: ■ Discussionmentioning

confidence: 99%

“…The soluble and amphiphilic properties of short-chain ceramides are in stark contrast to the insoluble and nonswelling nature of C16 and higher ceramides . Long-chain ceramides promote biological barrier function, while an increasing level of short-chain ceramides is associated with barrier damage . Ceramides could thus induce changes in lipid metabolism by disrupting the cell membrane and promoting the retention of contaminants that associate with the displaced phospholipids. , …”

Section: Discussionmentioning

confidence: 99%

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Quantitative Associations of Polluting Chemicals and Endogenous Biomolecules in Hair: An Observational Perspective from a Population-Based Study

Huang,

Liao,

Yang

et al. 2024

Environ. Sci. Technol. Lett.

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Hair is a valuable, non-invasive material for human biomonitoring. However, little is known about polluting contaminants in hair, particularly regarding the relationship between biocomponents and contaminant levels in hair. We measured the concentrations of 42 contaminants, including 11 phosphorus flame retardants (PFRs), 13 bisphenols (BPs), and 18 perfluoroalkyl and polyfluoroalkyl substances (PFAS), while simultaneously measuring the levels of keratin, melanin, and eight sphingolipids in hair samples. Long-chain sphingolipids (C20CER) were negatively associated with levels of PFRs, PFAS, and BPs, while C12CER and C14CER (short-chain) were positively associated with levels of PFRs and BPs. Furthermore, we observed an overall negative association between ∑7PFRs and endogenous biocomponents but a positive dose–effect relationship with ∑5BPs and biocomponents using Bayesian kernel machine regression models. Among the biocomponents, C20CER and C14CER contributed the most to the negative and positive associations, respectively. Specifically, a change in Ln C20CER (Z-score) concentration from the 25th to 75th percentile was associated with a decrease in ∑7PFRs of 47.0%-SD (−61.8%, −32.3%) when other biocomponents were at their median values. These findings provide new insights into the relationships between biocomponents and contaminants in hair, which is an essential step for the advancement of hair as a biomonitoring material.

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Research progress on the role of macrophages in acne and regulation by natural plant products

Zhao,

Wang,

et al. 2024

Front. Immunol.

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Acne vulgaris is one of the most common skin diseases. The current understanding of acne primarily revolves around inflammatory responses, sebum metabolism disorders, aberrant hormone and receptor expression, colonization by Cutibacterium acnes, and abnormal keratinization of follicular sebaceous glands. Although the precise mechanism of action remains incompletely understood, it is plausible that macrophages exert an influence on these pathological features. Macrophages, as a constituent of the human innate immune system, typically manifest distinct phenotypes across various diseases. It has been observed that the polarization of macrophages toward the M1 phenotype plays a pivotal role in the pathogenesis of acne. In recent years, extensive research on acne has revealed an increasing number of natural remedies exhibiting therapeutic efficacy through the modulation of macrophage polarization. This review investigates the role of cutaneous macrophages, elucidates their potential significance in the pathogenesis of acne, a prevalent chronic inflammatory skin disorder, and explores the therapeutic mechanisms of natural plant products targeting macrophages. Despite these insights, the precise role of macrophages in the pathogenesis of acne remains poorly elucidated. Subsequent investigations in this domain will further illuminate the pathogenesis of acne and potentially offer guidance for identifying novel therapeutic targets for this condition.

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The heterogeneity and complexity of skin surface lipids in human skin health and disease

Cited by 3 publications

References 150 publications

An evaluation of collagen peptide for transdermal delivery using Strat-M ® membrane and excised mouse skin

An evaluation of collagen peptide for transdermal delivery using Strat-M ® membrane and excised mouse skin

Quantitative Associations of Polluting Chemicals and Endogenous Biomolecules in Hair: An Observational Perspective from a Population-Based Study

Research progress on the role of macrophages in acne and regulation by natural plant products

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