The herbicide glyphosate is a potent inhibitor of 5-enolpyruvylshikimic acid-3-phosphate synthase

Steinrücken, Hans Christian; Amrhein, Nikolaus

doi:10.1016/0006-291x(80)90547-1

Cited by 950 publications

(562 citation statements)

References 9 publications

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“…29 The US Environmental Protection Agency 30 and the World Health Organization 31 have concluded that glyphosate is not mutagenic or carcinogenic. Since then, however, some experimental studies indicate genotoxic, hormonal and enzymatic effect in mammals, as reviewed.…”

Section: Discussionmentioning

confidence: 99%

Pesticide exposure as risk factor for non‐Hodgkin lymphoma including histopathological subgroup analysis

Eriksson

Hardell

Carlberg

et al. 2008

Intl Journal of Cancer

146

128

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We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to different agents was assessed by questionnaire. In total 910 (91%) cases and 1016 (92%) controls participated. Exposure to herbicides gave odds ratio (OR) 1.72, 95% confidence interval (CI) 1.18-2.51. Regarding phenoxyacetic acids highest risk was calculated for MCPA; OR 2.81, 95% CI 1.27-6.22, all these cases had a latency period >10 years. Exposure to glyphosate gave OR 2.02, 95% CI 1.10-3.71 and with >10 years latency period OR 2.26, 95% CI 1.16-4.40. Insecticides overall gave OR 1.28, 95% CI 0.96-1.72 and impregnating agents OR 1.57, 95% CI 1.07-2.30. Results are also presented for different entities of NHL. In conclusion our study confirmed an association between exposure to phenoxyacetic acids and NHL and the association with glyphosate was considerably strengthened.

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Section: Discussionmentioning

confidence: 99%

Pesticide exposure as risk factor for non‐Hodgkin lymphoma including histopathological subgroup analysis

Eriksson

Hardell

Carlberg

et al. 2008

Intl Journal of Cancer

146

128

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“…Much recent interest has been shown in the aroA gene product, 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase, of plants, which is the primary target for the herbicide glyphosate (Stalker et al, 1985;Steinrucken & Amrhein, 1980). Sequence analysis of proteins and nucleic acids provides a new and powerful approach to measure evolutionary relationships between organisms.…”

Section: Introductionmentioning

confidence: 99%

Cloning and DNA sequence analysis of the serC-aroA operon from Salmonella gallinarum; evolutionary relationships between the prokaryotic and eukaryotic aro A-encoded enzymes

Griffin¹,

Griffin²

1991

Microbiology

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The serC-aroA operon of Salmonella galfinarum was isolated from a gene library using a labelled oligonucleotide probe and by complementation of an aroA Escherichia cofi strain. The nucleotide sequence of a 2.6 kbp fragment was determined. The predicted amino acid sequence of the aroA gene product was compared to the equivalent sequence from ten other organisms. Computer-generated evolutionary trees clearly divide the eleven sequences into four different groups: Gram-negative bacteria, Gram-positive bacteria, fungi and plants. These trees depict a close evolutionary relationship between the sequences from Gram-negative bacteria and higher plants.

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“…The primary metabolic target site for this herbicide is 5-enolpyruvylshikimate 3-phosphate synthase, the penultimate enzyme of the shikimate pathway (1,12,28). Glyphosate inhibition is competitive with phosphoenolpyruvate, one of the substrates for this enzyme (3).…”

mentioning

confidence: 99%

Glyphosate Induces 3-Deoxy-d-arabino-Heptulosonate 7-Phosphate Synthase in Potato (Solanum tuberosum L.) Cells Grown in Suspension Culture

Pinto

Dyer²,

Weller³

et al. 1988

Plant Physiol.

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The activity of the first enzyme of the shikimate pathway, 3-deoxy-Darabino-heptulosonate 7-phosphate synthase, varies during the growth cycle of Solanum tuberosum L. cv superior cells in suspension culture. Maximum specific enzyme activity was observed midway through the linear phase of growth. When mid-log phase cells are exposed to glyphosate, the specific activity of the enzyme increases severalfold within 24 hours. The glyphosate-induced increase in enzyme activity is due to an increase in the amount of enzyme as determined by immunoblotting. Glyphosate (up to 2 millimolar) has no effect on the enzyme activity in vitro. Dehydroquinate synthase, the second enzyme of the shikimate pathway, is not induced by glyphosate.

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The herbicide glyphosate is a potent inhibitor of 5-enolpyruvylshikimic acid-3-phosphate synthase

Cited by 950 publications

References 9 publications

Pesticide exposure as risk factor for non‐Hodgkin lymphoma including histopathological subgroup analysis

Pesticide exposure as risk factor for non‐Hodgkin lymphoma including histopathological subgroup analysis

Cloning and DNA sequence analysis of the serC-aroA operon from Salmonella gallinarum; evolutionary relationships between the prokaryotic and eukaryotic aro A-encoded enzymes

Glyphosate Induces 3-Deoxy-d-arabino-Heptulosonate 7-Phosphate Synthase in Potato (Solanum tuberosum L.) Cells Grown in Suspension Culture

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