The herbal extract ALS-L1023 from Melissa officinalis reduces weight gain, elevated glucose levels and β-cell loss in Otsuka Long-Evans Tokushima fatty rats

Shin, Yujin; Lee, Dongju; Ahn, Junho; Lee, Mijeong; Shin, Soon Shik; Yoon, Michung

doi:10.1016/j.jep.2020.113360

Cited by 17 publications

(12 citation statements)

References 45 publications

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“…In a similar study by Shin et al (2021), the administration of ALS-L1023 (HFD with 0.4% or 0.8% ( w / w )) for four weeks to Otsuka Long-Evans Tokushima fatty (OLETF) rats resulted in a reduction in BW with no change in food intake [ 491 ]. The extract also markedly inhibited hyperglycaemia and hypoinsulinaemia and restored β -cell mass, severely impaired in rats.…”

Section: Resultsmentioning

confidence: 99%

“…The extract also markedly inhibited hyperglycaemia and hypoinsulinaemia and restored β -cell mass, severely impaired in rats. A reduction in lipid accumulation in the liver and skeletal muscle of obese rats was observed after treatment with ALS-L1023 [ 491 ]. In parallel, the expression levels of fatty acid oxidising enzymes [AMPK α 2, ACOX (Acyl-CoA Oxidase), MCAD (Medium-chain acyl-coenzyme A dehydrogenase), and VLCAD (Very Long Chain Acyl-CoA Dehydrogenase Deficiency)] increased in liver and skeletal muscle after ALS-L1023 treatment.…”

Section: Resultsmentioning

confidence: 99%

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Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

Lahlou,

Carvalho,

Pereira

et al. 2024

Pharmaceutics

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The Serra da Estrela Natural Park (NPSE) in Portugal stands out as a well-preserved region abundant in medicinal plants, particularly known for their pharmaceutical applications in diabetes prevention and treatment. This comprehensive review explores these plants’ botanical diversity, traditional uses, pharmacological applications, and chemical composition. The NPSE boast a rich diversity with 138 medicinal plants across 55 families identified as traditionally and pharmacologically used against diabetes globally. Notably, the Asteraceae and Lamiaceae families are prevalent in antidiabetic applications. In vitro studies have revealed their significant inhibition of carbohydrate-metabolizing enzymes, and certain plant co-products regulate genes involved in carbohydrate metabolism and insulin secretion. In vivo trials have demonstrated antidiabetic effects, including glycaemia regulation, insulin secretion, antioxidant activity, and lipid profile modulation. Medicinal plants in NPSE exhibit various activities beyond antidiabetic, such as antioxidant, anti-inflammatory, antibacterial, anti-cancer, and more. Chemical analyses have identified over fifty compounds like phenolic acids, flavonoids, terpenoids, and polysaccharides responsible for their efficacy against diabetes. These findings underscore the potential of NPSE medicinal plants as antidiabetic candidates, urging further research to develop effective plant-based antidiabetic drugs, beverages, and supplements.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

Lahlou,

Carvalho,

Pereira

et al. 2024

Pharmaceutics

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show abstract

“…The extract ALS-L1023 confirmed that the effects of nutraceuticals present in this herb reduce weight gain. This extract, which increases the level of AMPKα2, alleviates abdominal obesity and insulin resistance in C57BL/6J mice by increasing the mRNA levels of carnitine palmitoyltransferase 1 (CPT-1), medium-chain acyl-coenzyme A dehydrogenase (MCAD) [ 79 ]. Thus, the effects of the herbs depend on the different nutraceuticals obtained according to solvents used to prepare the extracts.…”

Section: Resultsmentioning

confidence: 99%

Nutraceuticals and the Network of Obesity Modulators

Ammendola¹,

d’Abusco

2022

Nutrients

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Obesity is considered an increasingly widespread disease in the world population, regardless of age and gender. Genetic but also lifestyle-dependent causes have been identified. Nutrition and physical exercise play an important role, especially in non-genetic obesity. In a three-compartment model, the body is divided into fat mass, fat-free mass and water, and obesity can be considered a condition in which the percentage of total fat mass is in excess. People with a high BMI index or overweight use self-medications, such as food supplements or teas, with the aim to prevent or treat their problem. Unfortunately, there are several obesity modulators that act both on the pathways that promote adipogenesis and those that inhibit lipolysis. Moreover, these pathways involve different tissues and organs, so it is very difficult to identify anti-obesity substances. A network of factors and cells contributes to the accumulation of fat in completely different body districts. The identification of natural anti-obesity agents should consider this network, which we would like to call “obesosome”. The nutrigenomic, nutrigenetic and epigenetic contribute to making the identification of active compounds very difficult. This narrative review aims to highlight nutraceuticals that, in vitro or in vivo, showed an anti-obesity activity or were found to be useful in the control of dysfunctions which are secondary to obesity. The results suggest that it is not possible to use a single compound to treat obesity, but that the studies have to be addressed towards the identification of mixtures of nutraceuticals.

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“…Otsuka Long-Evans Tokushima fatty (OLETF) rat was the result of selective breeding at the Tokushima Research Institute in 1982 [44,47]. OLETF rats have been used as a model for studying diabetes and obesity [48][49][50][51]. They are hyperphagic and develop mild obesity [44], which is a consequence of increased food intake and meal size, leading to increase in the bodyweight [49].…”

Section: Otsuka Long-evans Tokushima Fatty Ratmentioning

confidence: 99%

Murine Models of Obesity

et al. 2022

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Obesity, classified as an epidemic by the WHO, is a disease that continues to grow worldwide. Obesity results from abnormal or excessive accumulation of fat and usually leads to the development of other associated diseases, such as type 2 diabetes, hypertension, cancer, cardiovascular diseases, among others. In vitro and in vivo models have been crucial for studying the underlying mechanisms of obesity, discovering new therapeutic targets, and developing and validating new pharmacological therapies against obesity. Preclinical animal models of obesity comprise a variety of species: invertebrates, fishes, and mammals. However, small rodents are the most widely used due to their cost-effectiveness, physiology, and easy genetic manipulation. The induction of obesity in rats or mice can be achieved by the occurrence of spontaneous single-gene mutations or polygenic mutations, by genetic modifications, by surgical or chemical induction, and by ingestion of hypercaloric diets. In this review, we describe some of the most commonly used murine models in obesity research.

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The herbal extract ALS-L1023 from Melissa officinalis reduces weight gain, elevated glucose levels and β-cell loss in Otsuka Long-Evans Tokushima fatty rats

Cited by 17 publications

References 45 publications

Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

Overview of Ethnobotanical–Pharmacological Studies Carried Out on Medicinal Plants from the Serra da Estrela Natural Park: Focus on Their Antidiabetic Potential

Nutraceuticals and the Network of Obesity Modulators

Murine Models of Obesity

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