The hepatoprotective effects of squid gonad phospholipids on fatty liver disease in zebrafish

Xia, Qing; Liu, Kechun; Jia, Zhiyan; Li, Xiaobin; Zhang, Shanshan; Han, Liwen; Sun, Guoxiang; Hsiao, Chung-Der; Zhang, Yun

doi:10.1016/j.fbio.2020.100592

Cited by 5 publications

(1 citation statement)

References 40 publications

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“…PLs play an important role in activating cells, maintaining metabolism, hormone secretion, and enhancing human immunity and regeneration. In addition, PLs can promote fat metabolism, reduce serum cholesterol, improve blood circulation, and prevent fatty liver and cardiovascular diseases (Hannun & Obeid, 2008; Lee et al, 2010; Liu et al, 2016; Lordan et al, 2020; Xia et al, 2020; Zlomke et al, 2020). Marine PLs have unique advantages in physiological function and biological activity due to their high contents of PUFAs, such as docosahexaenoic acid and eicosapentaenoic acid (Ahmmed et al, 2021; Hassane et al, 2020); they have been shown in detail to exhibit anti‐inflammatory effects and prevent cardiovascular diseases (Li, Zhang, Xie, et al, 2021; Lordan et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Comparative bioactivity profile of phospholipids from three marine byproducts based on the zebrafish model

Xie

Zhu

et al. 2022

Journal of Food Biochemistry

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Phospholipids (PLs) are important components of physiological metabolism in animals and plants, and they have been widely used in clinical treatment, cosmetics, and industry. With the development of marine resources, marine PLs rich in polyunsaturated fatty acids have attracted increasing attention. As important marine resources, shrimp heads (SH), codfish roe (CR), and squid gonads (SG) contain a high PL content.The antithrombotic, antistroke, anti-inflammatory, pro-angiogenic, and cardioprotective activities of PLs from SH, CR, and SG were evaluated and compared using the in vivo zebrafish model. The results showed that the PL extracts of SH, CR, and SG had significant biological activities, which lays a theoretical foundation for the development and utilization of PLs in marine byproducts in the future, providing a new choice for the prevention of inflammatory and cardiovascular diseases.

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