The hepatoprotective effect of aminoguanidine in acute liver injury caused by CCl4 in rats

Kostić, Tomislav; Popović, Dejan; Perišić, Zoran; Stanojević, Dragana; Dakić, Sonja; Sarić, S; Radojković, Danijela; Apostolović, Svetlana; Božinović, Nenad; Zdravković, Snežana Ćirić; Milutinovic, Stefan; Živković, Nikola; Golubović, Mlađjan; Djordjevic, Miodrag; Damjanović, Radomir; Bell, Abraham; Đinđić, Boris

doi:10.1016/j.biopha.2022.113918

Cited by 7 publications

(5 citation statements)

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“…ALT is mainly localized in the cytoplasm, while AST is mainly found in the mitochondria. [ 38 ] We found that CCL 4 exposure increased the pro-oxidative marker MDA and the liver damage markers (ALT and AST), and it reduced the antioxidant defense capacity (SOD and CAT); these findings are similar to those of other studies. As a result of damage to the cell and subcellular membranes, CCL 4 increases ALT and AST activity.…”

Section: Discussionsupporting

confidence: 90%

The Inhibitory Effect of Geraniol on CCL4-induced Hepatorenal Toxicity in Pregnant Mice through the PI3K/AKT Signaling Pathway

Alzahrani,

Bekhet,

Ammar

et al. 2024

Saudi Journal of Medicine &Amp; Medical Sciences

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Background: Hepatotoxicity caused by CCL4 is well known. Geraniol (GNL) has high antioxidant effect that can induces liver regeneration. However, the protective effect of GNL effect on CCL4-induced hepatorenal toxicity in pregnant mice has not yet been studied. Objective: To investigate whether GNL could protect against oxidative stress induced by CCL4 via the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, which is regulated by phosphatidylinositol 3 kinase/protein kinase B (PI3K/AKT), and has been found to have protective effects on renal and hepatic tissues. Materials and Methods: Forty-eight female albino mice weighing 25–30 g were randomly allocated to 4 groups: Group I served as a control; Group II received a toxicity-inducing single dose of 15 μL of CCL4 on the 4th day after mating; Group III received 40 mg/kg GNL + CCL4 (with GNL from the 1st day of assimilation to delivery); and Group IV received GNL alone from the 1st day of assimilation to the end of the delivery period. GNL was evaluated for its protective effects on hepatotoxicity in CCL4-treated pregnant mice. Litter size, weight, survival rate, and resorption were recorded. In addition, H & E staining was done for liver and kidney pathology as well as biochemical markers and oxidative markers malondialdehyde, superoxide dismutase, and catalase were analyzed. Results: CCL4 significantly reduced survival rate and increased resorption after exposure. Alanine transaminase and aspartate aminotransferase concentrations in the serum, tissue MDA, blood urea nitrogen, and creatinine were increased after CCL4 exposure. GNL improved enzyme and antioxidant levels and prevented CCL4-induced hepatic injury in mice. Caspase-3 cleavage was decreased by GNL, which increased PI3K, phosphorylated AKT, Nrf2, and B-cell lymphoma 2. Conclusion: GNL demonstrates a protective effect against CCl4-induced hepatorenal toxicity, mediated through the activation of the PI3K/AKT signaling pathway and the upregulation of Nrf2. These findings highlight the potential therapeutic implications of GNL in mitigating oxidative stress and inflammation in liver and kidney tissues.

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Section: Discussionsupporting

confidence: 90%

The Inhibitory Effect of Geraniol on CCL4-induced Hepatorenal Toxicity in Pregnant Mice through the PI3K/AKT Signaling Pathway

Alzahrani,

Bekhet,

Ammar

et al. 2024

Saudi Journal of Medicine &Amp; Medical Sciences

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“…IL‐10, on the other hand, can assist in reducing the inflammatory injury in the liver by suppressing pro‐inflammatory mediators (TNF‐α, IL‐1β, and IL‐6). CCl 4 leads to a significant increase in the activity of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and Sorbitol dehydrogenase (SDH) due to damage to cell and subcellular membranes and their leakage from the cytoplasm into the systemic circulation (Kostic et al, 2022).…”

Section: Methods Of Study Designmentioning

confidence: 99%

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Thilagavathi

Begum

Varatharaj

et al. 2023

Phytotherapy Research

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Liver problems are a worldwide concern, and conventional medicinal therapies are ineffective. Hence, safeguarding the healthy liver is vital for good health and well‐being. Infections due to virus, immune problems, cancer, alcohol abuse, and an overdose of drugs are some of the causes of liver diseases. Antioxidants derived from medicinal plants and conventional dietary sources can protect the liver from damages caused by oxidative stress system and various chemicals. Plants and plant‐derived phytochemicals are appealing hepatoprotective agents since they have less side effects and still there is a lot of interest shown in using herbal tonics for treating liver disorders. This review therefore primarily focuses on newly discovered medicinal plants and compounds produced from plants that fall under the classifications of flavonoids, alkaloids, terpenoids, polyphenolics, sterols, anthocyanins, and saponin glycosides, all of which have the potential to be hepatoprotective. Hosta plantaginea, Ligusticum chuanxiong, Daniella oliveri, Garcinia mangostana, Solanum melongena, Vaccinium myrtillus, Picrorhiza kurroa, and Citrus medica are some potential plants having hepatoprotective effects. We conclude that these phytochemicals and the plant extracts listed above are used in the future to treat a variety of liver diseases, additional research is still needed to develop safer and more potent phytochemical drugs.

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“…The cytochrome P2E1 enzyme in the liver converts CCL 4 to the hazardous reactive trichloromethyl and trichloromethyl peroxide radicals [ 56 ]. These reactive radicals subsequently attach to unsaturated fatty acids in the membranes of hepatocytes, mitochondria, and the endoplasmic reticulum, initiating a chain lipid peroxidation process that causes hepatocyte and intracellular structural damage and death [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Novel drug therapy of acute hepatic failure induced in rats by a combination of tadalafil and Lepidium sativum

Sabra,

Mohammed,

Hassanein

et al. 2024

BMC Complement Med Ther

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Background Hepatocyte death and a systemic inflammatory response are the outcome of a complex chain of events mediated by numerous inflammatory cells and chemical mediators. The point of this study was to find out if tadalafil and/or Lepidium sativum (L. sativum) could help people who have been exposed to carbon tetrachloride (CCL4) and are experiencing acute moderate liver failure. This was especially true when the two were used together. Method and materials To cause mild liver failure 24 h before sacrifice, a single oral dosage of CCL4 (2.5 mL/kg b.w.) (50% in olive oil) was utilized. Furthermore, immunohistochemical expression of nuclear factor kappa B (NF-κB) as well as histological abnormalities were performed on liver tissue. Results The results showed that tadalafil and/or L. sativum, especially in combination, performed well to cure acute mild liver failure caused by CCL4. This was demonstrated by a decrease in NF-κB expression in the liver tissue and an improvement in organ damage markers observed in the blood and liver tissues. Furthermore, such therapy reduced interleukin1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels in the liver tissue. It’s worth noting that the tested combination resulted in greater liver improvement. Conclusions According to the findings, tadalafil and L. sativum, particularly in combination, have the ability to protect the liver from the negative effects of CCL4 exposure. Because of its capacity to improve liver function, restore redox equilibrium, and decrease inflammatory mediators, it is a prospective option for mitigating the negative effects of common environmental pollutants such as CCL4.

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The hepatoprotective effect of aminoguanidine in acute liver injury caused by CCl4 in rats

Cited by 7 publications

References 50 publications

The Inhibitory Effect of Geraniol on CCL4-induced Hepatorenal Toxicity in Pregnant Mice through the PI3K/AKT Signaling Pathway

The Inhibitory Effect of Geraniol on CCL4-induced Hepatorenal Toxicity in Pregnant Mice through the PI3K/AKT Signaling Pathway

Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds

Novel drug therapy of acute hepatic failure induced in rats by a combination of tadalafil and Lepidium sativum

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