The Hepatitis Viral Status in Patients With Hepatocellular Carcinoma

Chang, I–Shou; Huang, Shiu-Feng; Chen, Pei‐Jer; Chen, Chi‐Ling; Chen, Chao‐Long; Wu, Chien-Hung; Tsai, Cheng-Chung; Lee, Po‐Huang; Chen, Miin‐Fu; Lee, Chuan–Mo; Yu, Hsien‐Chung; Lo, Gin‐Ho; Yeh, Chi-Ju; Hong, Chih-Chen; Eng, Hock‐Liew; Wang, John; Tseng, Hui‐Hwa; Hsiao, Cheng-Hsiang; Wu, Hung‐Ming; Yen, Tsong; Liaw, Yun–Fan

doi:10.1097/md.0000000000003284

Cited by 34 publications

(28 citation statements)

References 31 publications

(38 reference statements)

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“…The incidence levels of alcoholism and cirrhosis differed significantly between the whole group of 2,153 patients with HBV‐HCC and the matched 420 patients with HBV‐HCC ( P = 0.0150). This difference may be due to the significant variation in the age distribution between the 2,153 patients with HBV‐HCC and the 411 patients with NBNC‐HCC ( P = 0.0000) 26. In contrast, the incidence levels of alcoholism and cirrhosis did not differ significantly between the entire HCV‐HCC patient cohort and the selected 420 patients with HCV‐HCC ( P = 0.5460).…”

Section: Resultsmentioning

confidence: 92%

“…High HBV DNA and HCV RNA levels were defined as ≥2 × 10 4 IU/mL and ≥ 2.3 × 10 4 IU/mL, respectively 26. No significant differences were observed in the viral titer distribution between the entire group of patients (2,153) with HBV‐HCC and the selected 420 patients with HBV‐HCC ( P = 0.9161) or between the entire group of patients with HCV‐HCC and the selected 420 patients with HCV‐CC ( P = 0.2481) (http://onlinelibrary.wiley.com/doi/10.1002/hep4.1182/full).…”

Section: Resultsmentioning

confidence: 99%

“…The TLCN published a detailed viral marker study of 3,843 patients with HCC recruited from 2005 to 2011 in the TLCN 26. HCC was diagnosed in these patients through histopathological examination (87.3%) and radiology (12.7%).…”

Section: Methodsmentioning

confidence: 99%

“…The TLCN has published a detailed viral hepatitis marker study of 3,843 patients with HCC recruited from 2005 to 2011 26. During the recruitment, blood samples of all 3,843 patients with HCC were routinely examined for viral markers, including HBV surface antigen (HBsAg), HBV DNA, HBV genotype, and anti‐HCV antibody.…”

mentioning

confidence: 99%

“…In published reports, the diagnosis of NBNC‐HCC only required negative results for both HBsAg and anti‐HCV,27, 28, 29, 30, 31, 32, 33, 34 and tests for serum HBV DNA were not performed. In this study, we added HBV DNA criteria (undetectable) for the diagnosis of NBNC‐HCC because among the 2,153 patients with HBV‐HCC and the 310 patients with B+C‐HCC in our detailed viral marker study report, we identified 202 patients (8.20%) who tested negative for HBsAg but positive for HBV DNA 26. The HBsAg‐negative but HBV DNA‐positive patients were considered to have occult HBV infection.…”

mentioning

confidence: 99%

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Metabolic risk factors are associated with non‐hepatitis B non‐hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B

Huang

Chang

Hong

et al. 2018

Hepatology Communications

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Metabolic risk factors, such as obesity, fatty liver, high lipidemia, and diabetes mellitus are associated with increased risk for nonviral hepatocellular carcinoma (HCC); however, few nonviral HCC studies have stratified patients according to underlying etiologies. From 2005 to 2011, 3,843 patients with HCC were recruited into the Taiwan Liver Cancer Network. Of these patients, 411 (10.69%) who were negative for hepatitis B virus (HBV), surface antigen, HBV DNA, and anti‐hepatitis C virus (HCV) antibody were classified as non‐HBV non‐HCV (NBNC)‐HCC. Detailed clinical analyses of these patients were compared with age‐ and sex‐matched patients with HBV‐HCC or HCV‐HCC for the associated metabolic risk factors. For this comparison, 420 patients with HBV‐HCC and 420 patients with HCV‐HCC were selected from the 3,843 patients with HCC. Multivariate analyses showed fatty liver (by echography), high triglyceride levels (>160 mg/dL), and diabetes mellitus history to be significantly associated only with NBNC‐HCC and not with the matched patients with HBV‐ or HCV‐HCC. When the patients with HCC were further divided into four groups based on history of alcoholism and cirrhotic status, the group without alcoholism and without cirrhosis exhibited the strongest association with the metabolic risk factors. Based on trend analyses, patients with NBNC‐HCC with or without alcoholism were significantly different from the matched patients with HBV‐ or HCV‐HCC, except for patients with alcoholism and cirrhosis, in having more than two of the above three risk factors. Conclusion: Metabolic risk factors are significantly associated with nonviral HCC, especially for patients without alcoholism in Taiwan. Because the prevalence of viral HCC is decreasing due to the success of universal vaccination and antiviral therapy, strategies for cancer prevention, prediction, and surveillance for HCC will require modification. (Hepatology Communications 2018;2:747‐759)

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Metabolic risk factors are associated with non‐hepatitis B non‐hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B

Huang

Chang

Hong

et al. 2018

Hepatology Communications

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The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level

Akinyemiju¹,

Abera²,

Ahmed³

et al. 2017

JAMA Oncol

1,472

672

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Global Burden of Disease Liver Cancer Collaboration IMPORTANCE Liver cancer is among the leading causes of cancer deaths globally. The most common causes for liver cancer include hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and alcohol use.OBJECTIVE To report results of the Global Burden of Disease (GBD) 2015 study on primary liver cancer incidence, mortality, and disability-adjusted life-years (DALYs) for 195 countries or territories from 1990 to 2015, and present global, regional, and national estimates on the burden of liver cancer attributable to HBV, HCV, alcohol, and an "other" group that encompasses residual causes.DESIGN, SETTINGS, AND PARTICIPANTS Mortality was estimated using vital registration and cancer registry data in an ensemble modeling approach. Single-cause mortality estimates were adjusted for all-cause mortality. Incidence was derived from mortality estimates and the mortality-to-incidence ratio. Through a systematic literature review, data on the proportions of liver cancer due to HBV, HCV, alcohol, and other causes were identified. Years of life lost were calculated by multiplying each death by a standard life expectancy. Prevalence was estimated using mortality-to-incidence ratio as surrogate for survival. Total prevalence was divided into 4 sequelae that were multiplied by disability weights to derive years lived with disability (YLDs). DALYs were the sum of years of life lost and YLDs.MAIN OUTCOMES AND MEASURES Liver cancer mortality, incidence, YLDs, years of life lost, DALYs by etiology, age, sex, country, and year. RESULTS There were 854 000 incident cases of liver cancer and 810 000 deaths globally in 2015, contributing to 20 578 000 DALYs. Cases of incident liver cancer increased by 75% between 1990 and 2015, of which 47% can be explained by changing population age structures, 35% by population growth, and −8% to changing age-specific incidence rates. The male-to-female ratio for age-standardized liver cancer mortality was 2.8. Globally, HBV accounted for 265 000 liver cancer deaths (33%), alcohol for 245 000 (30%), HCV for 167 000 (21%), and other causes for 133 000 (16%) deaths, with substantial variation between countries in the underlying etiologies.CONCLUSIONS AND RELEVANCE Liver cancer is among the leading causes of cancer deaths in many countries. Causes of liver cancer differ widely among populations. Our results show that most cases of liver cancer can be prevented through vaccination, antiviral treatment, safe blood transfusion and injection practices, as well as interventions to reduce excessive alcohol use. In line with the Sustainable Development Goals, the identification and elimination of risk factors for liver cancer will be required to achieve a sustained reduction in liver cancer burden. The GBD study can be used to guide these prevention efforts.

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Time trend and age‐specific gender difference in the incidence of liver cancer from 2009 to 2018 in Taiwan

Chen

Chang

2022

Adv in Digestive Medicine

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Liver cancer has a significant impact on global health. Taiwan is a country with a high incidence rate of liver cancer. Efforts in primary prevention and treatment of chronic hepatitis B and C are projected to decrease the liver cancer incidence in Taiwan. We used the Taiwan Cancer Registry data to explore the time trend of liver cancer incidence over the last decade, which showed a decreasing trend of 21% in males and 26.1% in females from 2009 to 2018. Both genders aged 30‐39 years had the greatest decrease in liver cancer incidence, while those >70 years old had the least decrease. Our study also showed gender disparity in liver cancer with a persistent male predominance over time. In the past decade, the liver cancer incidence had a 2.5 to 2.7 sex ratio (male to female) and varied gender differences at different ages. Sex ratios peaked at age 40‐49 years and gradually decreased as age increases. The pattern of age‐specific gender differences was similar between 2009 and 2018. This finding implies that female sex hormones may play a protective role in the development of liver cancer.

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The Hepatitis Viral Status in Patients With Hepatocellular Carcinoma

Cited by 34 publications

References 31 publications

Metabolic risk factors are associated with non‐hepatitis B non‐hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B

Metabolic risk factors are associated with non‐hepatitis B non‐hepatitis C hepatocellular carcinoma in Taiwan, an endemic area of chronic hepatitis B

The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level

Time trend and age‐specific gender difference in the incidence of liver cancer from 2009 to 2018 in Taiwan

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