The Hepatic Sinusoidal Endothelial Cell: Morphology, Function, and Pathobiology

DeLeve, Laurie D.

doi:10.1002/9780470747919.ch26

Cited by 7 publications

(7 citation statements)

References 132 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The liver is responsible, in part, for clearance of high molecular weight circulating proteins [21], and more severe hepatic dysfunction in the renal failure group, theoretically, could have contributed to a prolonged adduct elimination halflife in these subjects. However, subjects in both groups appeared similar with regard to peak ALT activity, peak serum APAP-CYS levels, and time until peak serum APAP-CYS concentrations.…”

Section: Discussionmentioning

confidence: 99%

Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose

et al. 2014

View full text Add to dashboard Cite

Elevated concentrations of serum acetaminophenprotein adducts, measured as protein-derived acetaminophen-cysteine (APAP-CYS), have been used to support a diagnosis of APAP-induced liver injury when histories and APAP levels are unhelpful. Adducts have been reported to undergo first-order elimination, with a terminal half-life of about 1.6 days. We wondered whether renal failure would affect APAP-CYS elimination half-life and whether continuous venovenous hemodiafiltration (CVVHDF), commonly used in liver failure patients, would remove adducts to lower their serum concentrations. Terminal elimination half-lives of serum APAP-CYS were compared between subjects with and without renal failure in a prospective cohort study of 168 adults who had ingested excessive doses of APAP. APAP-CYS concentrations were measured in plasma ultrafiltrate during CVVHDF at times of elevated serum adduct concentrations. Paired samples of urine and serum APAP-CYS concentrations were examined to help understand the potential importance of urinary elimination of serum adducts. APAP-CYS elimination half-life was longer in 15 renal failure subjects than in 28 subjects with normal renal function (41.3±2.2 h versus 26.8±1.1 h [mean ± SEM], respectively, p < 0.001). CVVHDF failed to remove detectable amounts of APAP-CYS in any of the nine subjects studied. Sixty-eight percent of 557 urine samples from 168 subjects contained no detectable APAP-CYS, despite levels in serum up to 16.99 μM. Terminal elimination half-life of serum APAP-CYS was prolonged in patients with renal failure for reasons unrelated to renal urinary adduct elimination, and consideration of prolonged elimination needs to be considered if attempting back-extrapolation of adduct concentrations. CVVHDF did not remove detectable APAP-CYS, suggesting approximate APAP-protein adduct molecular weights≥50,000 Da Toxicol. (2015) 11:169-178 DOI 10.1007 in the minority of instances was most compatible with renal adduct production and protein shedding into urine rather than elimination of serum adducts.

show abstract

Section: Discussionmentioning

confidence: 99%

Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose

et al. 2014

View full text Add to dashboard Cite

show abstract

“…In the presence of hepatic injury, LSEC become rapidly de-regulated and start dedifferentiation towards a capillarized phenotype, accompanied by the production and release of soluble factors that rapidly travel to neighbouring cells affecting their phenotype [26]. As an example, it has been demonstrated that LSEC-derived fibronectin affects HSC phenotype, promoting their activation [27].…”

Section: - Sinusoidal Crosstalk In Fibrosis Cirrhosis and Portal Hymentioning

confidence: 99%

Sinusoidal communication in liver fibrosis and regeneration

Marrone

Shah

Gracia‐Sancho

2016

Journal of Hepatology

251

208

View full text Add to dashboard Cite

Cellular crosstalk is a process through which a message is transmitted within an individual cell (intracellular crosstalk) or between different cells (intercellular crosstalk). Intercellular crosstalk within the liver microenvironment is critical for the maintenance of normal hepatic functions and for cells survival. Hepatic cells are closely connected to each other, work in synergy, and produce molecules that modulate their differentiation and activity. This review summarises the current knowledge regarding paracrine communication networks in parenchymal and non-parenchymal cells in liver fibrosis due to chronic injury, and regeneration after partial hepatectomy.

show abstract

“…Those allow the circulation of oxygen, nutrients and other products between the bloodstream and the liver parenchyma, while maintaining a certain barrier function. Besides this key role, they also participate in other essential processes like inflammation, endocytosis and vascular tone regulation [6][7][8].…”

Section: Sinusoidal Cell Componentsmentioning

confidence: 99%

Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical

Boyer‐Díaz¹,

Morata²,

Aristu-Zabalza³

et al. 2020

Nutrients

View full text Add to dashboard Cite

Chronic liver disease constitutes a growing public health issue worldwide, with no safe and effective enough treatment clinical scenarios. The present review provides an overview of the current knowledge regarding advanced chronic liver disease (ACLD), focusing on the major contributors of its pathophysiology: inflammation, oxidative stress, fibrosis and portal hypertension. We present the benefits of supplementation with docosahexaenoic acid triglycerides (TG-DHA) in other health areas as demonstrated experimentally, and explore its potential as a novel nutraceutical approach for the treatment of ACLD and portal hypertension based on published pre-clinical data.

show abstract

The Hepatic Sinusoidal Endothelial Cell: Morphology, Function, and Pathobiology

Cited by 7 publications

References 132 publications

Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose

Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose

Sinusoidal communication in liver fibrosis and regeneration

Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical

Contact Info

Product

Resources

About