The hemolytic activity of some trialkyltin and triphenyltin compounds

Byington, Keith H.; Yeh, Richard; Forte, Leonard R.

doi:10.1016/0041-008x(74)90194-x

Cited by 61 publications

(14 citation statements)

References 12 publications

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“…Different types of rat cell, such as red blood cells [5,21], hepatocytes (unpublished observations) and in particular bone marrow cells and thymocytes [5] were shown to be very sensitive to the membrane damaging properties of TBTC. Using a phosphate-buffered saline/gluc buffer, exposure of thymocytes to TBTC resulted in cell loss at concentrations higher than 2 #M and membrane damage from a level of 1 #M (incubated for 2 h or more; Fig.…”

Section: Discussionmentioning

confidence: 89%

Effects of tri-n-butyltin chloride on energy metabolism, macromolecular synthesis, precursor uptake and cyclic AMP production in isolated rat thymocytes

Snoeij

Punt

Penninks

et al. 1986

Biochimica et Biophysica Acta (BBA) - Bioenergetics

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The inhibitor of oxidative phosphorylation tri-n-butyltin chloride (TBTC) causes membrane damage and disintegration of isolated rat thymocytes at concentrations higher than 1 ixM. From a concentration of 0.1 I~M, TBTC disturbs energy metabolism as indicated by an increase in methylglucose uptake, glucose consumption and lactate production and by a decrease in cellular ATP levels. Over the same TBTC concentration range, the incorporation of DNA, RNA and protein precursors are markedly reduced. Moreover the production of cyclic AMP upon stimulation of the cells with prostaglandin E 1 is effectively inhibited. These effects cannot be explained by an inhibition of nucleoside kinase activity, amino acid uptake or adenylate cyclase activity. The effects of TBTC on macromolecular synthesis and cyclic AMP production are possibly due to a disturbance of the cellular energy state.

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Section: Discussionmentioning

confidence: 89%

Effects of tri-n-butyltin chloride on energy metabolism, macromolecular synthesis, precursor uptake and cyclic AMP production in isolated rat thymocytes

Snoeij

Punt

Penninks

et al. 1986

Biochimica et Biophysica Acta (BBA) - Bioenergetics

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“…In a concentration range of 10 -5 to 2 × 10 -4 M, the lipophilic homologs, tripropyltin, tributyltin, triphenyltin, and tricyclohexyltin caused lysis of red blood cells of many animal species (Byington et al, 1974;Snoeij et al, 1986a). At even lower concentrations (10 -6 to 10 -5 M), membrane integrity of rat bone marrow cells and rat thymocytes was affected by tributyltin (Snoeij et al, 1986a).…”

Section: Effects On Cellular Functionsmentioning

confidence: 97%

Biological activity of organotin compounds—An overview

Snoeij

Penninks

Seinen

1987

Environmental Research

344

131

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As a consequence of the rapid expansion of the uses and applications of the organotin compounds, the concern about their environmental and health effects is increasing. The main subject of this overview is the current understanding of the mammalian toxicity of the organotin compounds. Four different types of target organ toxicity, namely neurotoxicity, hepatotoxicity, immunotoxicity, and cutaneous toxicity, are discussed in more detail. The effects of the organotin compounds on the mitochondfial and cellular level are summarized and discussed in relation to the mode of action of these compounds on the central nervous system, the liver and bile duct, the immune system, and the skin. © 1987 Academic Press, Inc. ORGANOTIN COMPOUNDS: APPLICATIONS AND TOXICITY Organotin CompoundsTin can be present as an element in a wide variety of both inorganic and organometallic compounds. Organometallic tin compounds or organotins are characterized by the presence of at least one covalent carbon-tin bond. Although tin may exist either in the Sn 2+ or in the Sn 4+ oxidation state, almost all organotins have a tetravalent structure. Depending on the number of organic moieties, the organotin compounds are classified as mono-, di-, tri-, and tetraorganotins. In compounds of industrial importance, methyl, butyl, octyl, and phenyl groups form the organic substituents, while the anion is usually chloride, fluoride, oxide, hydroxide, carboxylate, or thiolate. All alkyltin compounds refered to in this article contain unbranched saturated hydrocarbon side chains (n-alkyltins).

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“…Hemolytic anemia has been observed in rats that have been injected with triphenyltin [28]. Rat hemoglobin avidly binds organic tin, while other ruminant, hu public health, we have shown that cord RBC hexokinase is more resistant to the effects of TTB than adult RBC hexokinase.…”

Section: Discussionmentioning

confidence: 77%

Effect of Triethyltin on Enzyme Activity in Human Adult and Cord Red Cells

Patritti-Laborde¹,

Lachant²,

Tomoda³

et al. 1986

Enzyme

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Since organotin compounds represent an environmental health hazard, we determined the effect of triethyltin bromide (TTB) on red blood cell (RBC) enzyme activity. TTB produced a concentration-dependent inhibition of hexokinase and pyrimidine 5'-nucleotidasc for both adult and cord RBC. D-Glucose, but not ATP or MgCl(2), prevented the hexokinase inhibition by TTB. Glucose-6-phosphate dehydrogenase, adenylate kinase, and hypoxanthine- guanine phosphoribosyltransferase were also inhibited by TTB. Cord RBC enzymes were more resistant to the effects of TTB than were adult RBC enzymes. Although TTB is a potent inhibitor of hexokinase, physiologic concentrations of glucose appear to protect the RBC during clinical tin intoxication.

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The hemolytic activity of some trialkyltin and triphenyltin compounds

Cited by 61 publications

References 12 publications

Effects of tri-n-butyltin chloride on energy metabolism, macromolecular synthesis, precursor uptake and cyclic AMP production in isolated rat thymocytes

Effects of tri-n-butyltin chloride on energy metabolism, macromolecular synthesis, precursor uptake and cyclic AMP production in isolated rat thymocytes

Biological activity of organotin compounds—An overview

Effect of Triethyltin on Enzyme Activity in Human Adult and Cord Red Cells

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