The Hemodynamic Effects of Hypotensive Drugs in Man

Freis, Edward D.; Rose, John C.; Higgins, Thomas F.; Finnerty, Frank A.; Kelley, Robert T.; Partenope, Edward A.

doi:10.1161/01.cir.8.2.199

Cited by 134 publications

(36 citation statements)

References 7 publications

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“…The increase in cardiac output observed in rabbits using microspheres agrees with that in clinical studies by Wilkinson, Backman & Hecht (1952), Fries, Rose, Higgins, Finnerty, Kelley & Partenope (1953) and Stein & Hecht (1955). Similarly the large increases in renal and coronary flows agree with those found in man by Reubi (1950), Wilkinson et al (1952), Stein & Hecht (1955 and Crumpton, Rowe, Crosley, Maxwell & Huston (1953).…”

Section: Discussionsupporting

confidence: 86%

THE USE OF RADIOACTIVE MICROSPHERES TO COMPARE THE EFFECTS OF HYDRALAZINE, GUANETHIDINE AND SK&F 24260 ON THE REDISTRIBUTION OF CARDIAC OUTPUT IN ANAESTHETIZED RABBITS

Johnston

1975

British J Pharmacology

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IThe use of radioactive microspheres is described for the measurement of cardiac output in anaesthetized rabbits and its redistribution after the administration of drugs which lower blood pressure.2 Hydralazine increased peripheral vascular conductance by 123%. The vascular beds in which it had most effect were those of the carcass (mainly muscle) and the kidneys. 3 SK&F 24260,(1,4 dihydro-2, 6-dimethyl-4-(2-trifluormethylphenyl)-3,5,-pyridinedicarboxylic acid diethyl ester), had similar vasodilator actions. Its effect in the carcass contributed relatively more to the increase of total peripheral conductance. It also caused a remarkable degree of cerebral vasodilatation. 4 Guanethidine had a relatively small effect on total peripheral conductance and lowered blood pressure mainly by reducing stroke volume and cardiac output.

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Section: Discussionsupporting

confidence: 86%

THE USE OF RADIOACTIVE MICROSPHERES TO COMPARE THE EFFECTS OF HYDRALAZINE, GUANETHIDINE AND SK&F 24260 ON THE REDISTRIBUTION OF CARDIAC OUTPUT IN ANAESTHETIZED RABBITS

Johnston

1975

British J Pharmacology

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“…The pattern of change in renal function was qualitatively similar to that observed after certain other hypotensive agents including veratrum viride (9), the dihydrogenated alkaloids of ergot (22) and sodium nitrite given as a single, oral dose (23). The renal vasculature did not share in the decrease in vascular resistance associated with the fall in arterial pressure.…”

Section: Discussionsupporting

confidence: 69%

“…This pattern of change has been observed with hypotensive agents of all types tested in this laboratory (23) and therefore probably is secondary to the sudden alteration of arterial pressure rather than to any specific action of individual drugs on the kidney.…”

Section: Discussionsupporting

confidence: 58%

The Hemodynamic Effects of Hypotensive Drugs in Man. Iii. Hexamethonium 123

Freis¹,

Rose²,

Partenope³

et al. 1953

J. Clin. Invest.

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While searching for derivatives of d-tubocurarine, Barlow and Ing (1) and Paton and Zaimis (2) independently synthesized a series of polymethylene bistrimethylammonium salts. The latter investigators demonstrated that the pharmacological properties of this series were related to the length of the polymethylene chain; the decacompound produced neuromuscular block while the penta and hexa-compounds prevented the transmission of impulses across the synapses in all autonomic ganglia. They also carried out preliminary trials in man (3) but Arnold and Rosenheim were the first to use these agents in hypertension (4). Finally, Restall and Smirk demonstrated that it was possible to reduce blood pressure and obtain clinical improvement in hypertensive patients for long periods by the use of repeated parenteral doses of hexamethonium (5).Studies in this laboratory have confirmed the observations of Restall and Smirk and in addition have shown the potentiating effect of 1-hydrazinophthalazine (Apresoline) when alternated with doses of hexamethonium in patients with hypertension (6, 7). Our studies also suggested that hexamethonium may be useful in the treatment of

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“…The effects most frequently observed are a slight decrease in renal plasma flow and a more marked fall in the glomerular filtration rate, sodium clearance, and urine volume (Freis et al, 1953;Notter et al, 1956;Novack et al, 1961;Vorburger et al, 1968: Reubi, 1978. However, vasodilating drugs such as hydralazine and the pyrogenic substances increase the renal plasma flow (Goldring & Chasis, 1944;Imhof et al, 1956;Reubi, 1978).…”

Section: Introductionmentioning

confidence: 99%

Acute effects of combined vasodilation and beta‐adrenoceptor blockade with prizidilol on renal function.

Boehringer¹,

Weidmann²,

Link³

et al. 1983

Brit J Clinical Pharma

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1 The effects of a single oral dose of 600 mg of prizidilol on renal function were studied 5 to 6 h after dosing in six normal subjects and eight patients with essential hypertension. 2 Mean arterial blood pressure was reduced to 92% of the control value in normal subjects and to 75% in hypertensive patients. Heart rate increased slightly. 3 In normal subjects, effective renal plasma flow was increased to 107% of control values while glomerular filtration rate (83%), filtration fraction (79%), sodium (84%) and potassium (50%) clearances were significantly decreased. 4 In hypertensive subjects, effective renal plasma flow was increased to 120% of control values, while glomerular filtration rate (67%), filtration fraction (57%), sodium (27%) and potassium (72%) clearances were significantly decreased. 5 Plasma noradrenaline increased significantly in normal subjects (150%) and in patients (173%).Plasma renin activity, aldosterone and epinephrine levels did not change consistently. 6 The results indicate that the acute effects of prizidilol on blood pressure and renal function are more marked in hypertensive than in normotensive subjects. Prizidilol increases renal plasma flow like hydralazine and depresses glomerular filtration rate and fractional sodium excretion like endralazine. In addition to the fall in arterial pressure, efferent vasodilation and/or a specific effect on the glomerular ultrafiltration coefficient Kf may account for the striking decrease in filtration fraction.

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The Hemodynamic Effects of Hypotensive Drugs in Man

Cited by 134 publications

References 7 publications

THE USE OF RADIOACTIVE MICROSPHERES TO COMPARE THE EFFECTS OF HYDRALAZINE, GUANETHIDINE AND SK&F 24260 ON THE REDISTRIBUTION OF CARDIAC OUTPUT IN ANAESTHETIZED RABBITS

THE USE OF RADIOACTIVE MICROSPHERES TO COMPARE THE EFFECTS OF HYDRALAZINE, GUANETHIDINE AND SK&F 24260 ON THE REDISTRIBUTION OF CARDIAC OUTPUT IN ANAESTHETIZED RABBITS

The Hemodynamic Effects of Hypotensive Drugs in Man. Iii. Hexamethonium 123

Acute effects of combined vasodilation and beta‐adrenoceptor blockade with prizidilol on renal function.

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