The Hemodynamic Effects of Cocaine During Acute Controlled Hemorrhage in Conscious Rats

Abstract

Although transient, cocaine blunted the hypotensive response to acute controlled hemorrhage and resulted in tachycardia.

Physostigmine Does Not Effect Arousal but Produces Toxicity in an Animal Model of Severeγ-hydroxybutyrate Intoxication

“…Baseline HR was not measured in this protocol because the unanesthetized rat would not tolerate this external monitor. In a previous study, the HR in awake, unanesthetized male Sprague-Dawley rats was between 446 and 491 beats/min, 30 and another study reported an HR between 320 and 480 beats/min. 15 In this study, there appeared to be a slight slowing of the HR following administration of GBL compared with previous measurement.…”