The Hemodynamic Effect of Total Liquid Ventilation in Piglets With Reduced Cardiac Function After Cardiopulmonary Bypass

Jiang, Lijun; Yu, Cong; He, Jiamin; Ni, Chengyao; Wang, Qiang

doi:10.1111/j.1525-1594.2010.01169.x

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Severe cardiac injury and cardiac dysfunction are the main consequences of CPB surgery . Consistent with these findings, our data showed that the levels of cardiac injury biomarkers, including plasma creatine kinase MB and troponin I, significantly elevated 2 hours after CPB (Figure A,B).…”

Section: Resultssupporting

confidence: 87%

Activation of AMPK alleviates cardiopulmonary bypass‐induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder

Wang

Cao

Yin

et al. 2018

Cardiovascular Therapeutics

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Summary Recent years, studies have demonstrated that hyperglycemia is one of the main manifestations after cardiac surgeries, which contributes to myocardial injuries and increases the chance of subsequent complications and mortality in such patients. However, strategies targeting at glucose metabolic disorder after cardiac surgeries to attenuate myocardial injuries are inadequately studied. In this study, a rat model of cardiopulmonary bypass (CPB) was applied to investigate the role of Adenosine 5'‐monophosphate‐activated protein kinase (AMPK) in modulating myocardial glucose metabolic‐induced cardiac injuries after cardiac surgery. The results revealed that CPB elicited significant cardiac dysfunction, and pronouncedly elevated the markers of myocardial injuries including serum creatine kinase MB and cardiac troponin I. Additionally, blunted myocardial glucose uptake after CPB was associated with decreased membrane glucose transporter 4 (GLUT4) content. However, pretreatment of AMPK agonist 5‐aminoimidazole‐4‐carboxamide1‐β‐D‐ribofuranoside (AICAR) at the beginning of CPB activated AMPK, enhanced phosphorylation of Akt substrate 160 (AS160), and increased myocardial membrane content of GLUT4. Meanwhile, improved myocardial glucose uptake and more importantly alleviated cardiac injury were also observed after CPB pretreated with AICAR. Moreover, the application of a mutant form of AS160 (AS160‐4P) abolished the beneficial effect of AICAR, as evidenced by impaired cardiac glucose uptake, reduced myocardial membrane GLUT‐4 translocation, increased cardiac injury markers, and deterioration of cardiac function after CPB. In conclusion, it was suggested in this study that preactivation of AMPK by AICAR improved myocardial glucose uptake by promoting AS160 dependent myocardial membrane GLUT‐4 translocation, which ultimately provided a potent cardioprotective effect.

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Section: Resultssupporting

confidence: 87%

Activation of AMPK alleviates cardiopulmonary bypass‐induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder

Wang

Cao

Yin

et al. 2018

Cardiovascular Therapeutics

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“…Other articles focused on the use of liquid ventilation after cardiac arrest (n = 8), (Yoshida et al, 2005;Staffey et al, 2008;Riter et al, 2009;Albaghdadi et al, 2011;Chenoune et al, 2011;Darbera et al, 2013;Tissier et al, 2014;Kohlhauer et al, 2015) during coronary artery occlusion (CAO, n = 5) (Tissier et al, 2007(Tissier et al, , 2009(Tissier et al, , 2013Chenoune et al, 2010;Darbera et al, 2012) or for lung preservation (n = 2) (Yang et al, 2005;Jiang et al, 2006). Two additional articles evaluated the hemodynamic tolerance of TLV Jiang et al, 2011).…”

Section: Resultsmentioning

confidence: 98%

“…A study also investigated the cardiovascular tolerance of hypothermic TLV in a piglet model of cardiopulmonary bypass ( Jiang et al, 2011). The authors demonstrated that mean pulmonary arterial pressure was not altered by TLV compared to Control conditions.…”

Section: Applications In Resuscitationmentioning

confidence: 96%

Liquid Ventilation for the Induction of Ultrafast Hypothermia in Resuscitation Sciences: A Review

Kohlhauer

Berdeaux

Kerber

et al. 2016

Therapeutic Hypothermia and Temperature Management

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Liquid ventilation was initially proposed for lung lavage and respiratory support. More recently, it was also investigated as an experimental strategy for ultrafast cooling or organ preservation during ischemic disorders. The goal of this article is to identify and review the studies that investigated liquid ventilation in the field of resuscitation sciences. An exhaustive analysis of the literature was performed using the Medline database up to 15th September 2015. Articles were selected according to their relevance. All articles focusing on respiratory support were excluded. On the basis of 76 retrieved studies from the Medline database, 29 were included in this review. All studies were experimental reports and most of them investigated the cooling properties of liquid ventilation in animal models of experimental cardiac arrest or coronary artery occlusion in rabbits or pigs. Animal studies demonstrated a wide range of potential applications of total liquid ventilation in resuscitation sciences. This strategy is able to provide ultrafast cooling, independent of the body weight. In animal models of cardiopulmonary resuscitation, it was shown to provide potent benefits widely linked to cooling rapidity.

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“…Lijun Jiang et al. (72) of Zhejiang University, Hangzhou, China investigated the hemodynamic effect of total liquid ventilation (TLV) in piglets with preexisting cardiac dysfunction. After onset of cardiopulmonary dysfunction induced by CPB, piglets were randomly treated with TLV or conventional gas ventilation for 240 min.…”

Section: Cardiopulmonary Support and Membrane Oxygenationmentioning

confidence: 99%

Artificial Organs 2011: A Year in Review

Malchesky¹

2012

Artificial Organs

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In this Editor's Review, articles published in 2011 are organized by category and briefly summarized. As the official journal of The International Federation for Artificial Organs, The International Faculty for Artificial Organs, and the International Society for Rotary Blood Pumps, Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level."Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ replacement, recovery, and regeneration from all over the world. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers, the quality expected from such a journal would not be possible. We also express our special thanks to our Publisher, Wiley-Blackwell, for their expert attention and support in the production and marketing of Artificial Organs. In this Editor's Review, that historically has been widely well-received by our readership, we aim to provide a brief reflection of the currently available worldwide knowledge that is intended to advance and better human life while providing insight for continued application of technologies and methods of organ replacement, recovery, and regeneration. We look forward to recording further advances in the coming years.

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The Hemodynamic Effect of Total Liquid Ventilation in Piglets With Reduced Cardiac Function After Cardiopulmonary Bypass

Cited by 4 publications

References 14 publications

Activation of AMPK alleviates cardiopulmonary bypass‐induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder

Activation of AMPK alleviates cardiopulmonary bypass‐induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder

Liquid Ventilation for the Induction of Ultrafast Hypothermia in Resuscitation Sciences: A Review

Artificial Organs 2011: A Year in Review

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