The hematological parameters in testicular cancer

Çalışkan, Selahattin; Kaba, Selçuk; Özsoy, Emrah; Koca, Orhan; Akyüz, Mehmet; Öztürk, Metin İshak

doi:10.1016/j.jons.2017.10.002

Cited by 5 publications

(6 citation statements)

References 14 publications

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“…In clinical practice, TGCT has been divided into two main categories, seminomatous germ cell tumor (SGCT) and non-seminomatous germ cell tumor (NSGCT) [10]. As indicated earlier, the most common form of testicular tumor is Germ cell tumor (GCT), accounting for more than 95% of all testicular malignancies [11]. Three types of GCTs are generally recognized in the testes: (i) Type I -Yolk sac and teratomas of infants, (ii) Type II -Seminomatous and nonseminomatous of elderly patients, and (iii) Type III -Spermatocytic seminomas [10].…”

Section: Introductionmentioning

confidence: 99%

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Current Insights into Interethnic Variability in Testicular Cancers: Population Pharmacogenetics, Clinical Trials, Genetic Basis of Chemotherapy- Induced Toxicities and Molecular Signal Transduction

Vasistha

Kothari

Mishra

et al. 2020

CTMC

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: Testicular cancer is an aggressive malignancy with a rising incidence rate across the globe. Testicular germ cell tumors are the most common diagnoses, and surgical removal of the testes is often a radical necessity along with chemotherapy and radiotherapy. While seminomas are receptive to radiotherapy as well as chemotherapy, non-seminomatous germ cell tumors respond to chemotherapy only. Due to the singular nature of testicular cancers with associated orchiectomy and mortality, it is important to study the molecular basis and genetic underpinnings of this group of cancers across male populations globally. In this review, we shed light on the population pharmacogenetics of testicular cancer, pediatric and adult tumors, current clinical trials, genetic determinants of chemotherapy-induced toxicity in testicular cancer as well as the molecular signal transduction pathways operating in this malignancy. Taken together, our discussions will help in enhancing our understanding of genetic factors in testicular carcinogenesis and chemotherapy-induced toxicity, augment our knowledge of this aggressive cancer at the cellular and molecular level, as well as improve precision medicine approaches to combat this disease.

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Section: Introductionmentioning

confidence: 99%

“…While seminomas are receptive to both radiotherapy and chemotherapy, non-seminomatous GCTs respond to chemotherapy only [11]. Testicular cancer in men accounts for approximately 1-2% of tumors [12].…”

Section: Introductionmentioning

confidence: 99%

Current Insights into Interethnic Variability in Testicular Cancers: Population Pharmacogenetics, Clinical Trials, Genetic Basis of Chemotherapy- Induced Toxicities and Molecular Signal Transduction

Vasistha

Kothari

Mishra

et al. 2020

CTMC

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“…Apart from serum ferritin, we also focused on the NLR--a novel proposed indicator of systemic inflammation in recent years. NLR Frontiers in Molecular Biosciences frontiersin.org was proved to have significant prognostic value among various diseases with inflammatory risk, such as CVD, COVID-19, renal cell carcinoma and sepsis (Afari and Bhat, 2016;Çalışkan et al, 2018;Huang et al, 2020;Pirsalehi et al, 2020). In addition, the research by Yilmaz et al indicated that high NLR was associated markedly with the existence of uric acid and proteinuria in CKD patients (Yilmaz et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Serum ferritin and neutrophil-to-lymphocyte ratio predict all-cause mortality in patients receiving maintenance hemodialysis: a prospective study

He,

Li,

et al. 2024

Front. Mol. Biosci.

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Introduction: Maintenance hemodialysis is an effective treatment for end-stage renal disease patients. A critical factor contributing to the deterioration and death of maintenance hemodialysis patients is inflammation. Therefore, we focused on two inflammatory markers, serum ferritin and neutrophil-to-lymphocyte ratio, to speculate whether they could predict the prognosis of maintenance hemodialysis patients.Patients and methods: We followed 168 patients with maintenance hemodialysis from July 2019 to July 2022 with the endpoint of all-cause death or follow-up completion. Receiver operating characteristic curves were plotted to assess the values of serum ferritin, neutrophil-to-lymphocyte ratio and serum ferritin combined with neutrophil-to-lymphocyte ratio to predict the outcomes of maintenance hemodialysis patients. Kaplan-Meier survival curves were constructed to compare survival rates over time.Results: Receiver operating characteristic curves demonstrated that the best cut-off value of serum ferritin for predicting the prognosis of maintenance hemodialysis patients was 346.05 μg/L, and that of neutrophil-to-lymphocyte ratio was 3.225. Furthermore, a combination of both had a more excellent predicting value than either index (p < 0.05). Kaplan-Meier survival curve analyses revealed that low serum ferritin levels and low neutrophil-to-lymphocyte ratio had a higher probability of survival than high ferritin levels and high neutrophil-to-lymphocyte ratio, separately.Conclusion: Elevated serum ferritin and neutrophil-to-lymphocyte ratio are closely related to all-cause mortality among maintenance hemodialysis patients, for which they may be predictors of all-cause mortality. Additionally, the combination of the two has a much higher predictor value for the prognosis of maintenance hemodialysis patients.

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“…Recent literature highlights that the association between systemic inflammation and tumor development is confirmed in various solid organ cancers [ 7 ]. Since complete blood count can signify underlying systemic inflammation, the Neutrophil to Lymphocyte Ratio (NLR) invariably serves as an indicator of tissue inflammation in cancer [ 8 ]. The NLR measures the systemic inflammatory and immunological responses.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in penile cancer: A systematic review and meta-analysis

Saputra¹,

Hidayatullah²,

Kloping³

et al. 2022

Annals of Medicine &Amp; Surgery

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The hematological parameters in testicular cancer

Cited by 5 publications

References 14 publications

Current Insights into Interethnic Variability in Testicular Cancers: Population Pharmacogenetics, Clinical Trials, Genetic Basis of Chemotherapy- Induced Toxicities and Molecular Signal Transduction

Current Insights into Interethnic Variability in Testicular Cancers: Population Pharmacogenetics, Clinical Trials, Genetic Basis of Chemotherapy- Induced Toxicities and Molecular Signal Transduction

Serum ferritin and neutrophil-to-lymphocyte ratio predict all-cause mortality in patients receiving maintenance hemodialysis: a prospective study

Prognostic value of neutrophil-to-lymphocyte ratio (NLR) in penile cancer: A systematic review and meta-analysis

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