The Helical Ventricular Myocardial Band of Torrent-Guasp

Kočica, Mladen J.; Corno, Antonio F.; Lačković, Vesna; Kanjuh, Vladimir

doi:10.1053/j.pcsu.2007.01.006

Cited by 30 publications

(16 citation statements)

References 119 publications

(105 reference statements)

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“…Interestingly, the left-sided patterning of adrenergic-derived cells in the adult myocardium does not coincide with any known gene expression localization profiles; however, it appears to share anatomical similarity with the ascending segment of the helical ventricular myocardial band (HVMB) described by Torrent-Guasp et al [31], [32]. Although controversial and not universally accepted [33], [34], the HVMB model describes the directional orientation and intricate looping of myocardium that occurs in order to form two independent ventricles that function as a single unit.…”

Section: Discussionmentioning

confidence: 95%

Distinctive Left-Sided Distribution of Adrenergic-Derived Cells in the Adult Mouse Heart

et al. 2011

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Adrenaline and noradrenaline are produced within the heart from neuronal and non-neuronal sources. These adrenergic hormones have profound effects on cardiovascular development and function, yet relatively little information is available about the specific tissue distribution of adrenergic cells within the adult heart. The purpose of the present study was to define the anatomical localization of cells derived from an adrenergic lineage within the adult heart. To accomplish this, we performed genetic fate-mapping experiments where mice with the cre-recombinase (Cre) gene inserted into the phenylethanolamine-n-methyltransferase (Pnmt) locus were cross-mated with homozygous Rosa26 reporter (R26R) mice. Because Pnmt serves as a marker gene for adrenergic cells, offspring from these matings express the β-galactosidase (βGAL) reporter gene in cells of an adrenergic lineage. βGAL expression was found throughout the adult mouse heart, but was predominantly (89%) located in the left atrium (LA) and ventricle (LV) (p<0.001 compared to RA and RV), where many of these cells appeared to have cardiomyocyte-like morphological and structural characteristics. The staining pattern in the LA was diffuse, but the LV free wall displayed intermittent non-random staining that extended from the apex to the base of the heart, including heavy staining of the anterior papillary muscle along its perimeter. Three-dimensional computer-aided reconstruction of XGAL+ staining revealed distribution throughout the LA and LV, with specific finger-like projections apparent near the mid and apical regions of the LV free wall. These data indicate that adrenergic-derived cells display distinctive left-sided distribution patterns in the adult mouse heart.

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Section: Discussionmentioning

confidence: 95%

Distinctive Left-Sided Distribution of Adrenergic-Derived Cells in the Adult Mouse Heart

et al. 2011

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“…Future research should focus on evaluation of spiral or oblique shaped configurations around the heart in advanced bench models such as dynamic setups or an ex vivo porcine cadaver model. The helical ventricular myocardial band cardiac fiber orientation should be acknowledged in these designs 13. This represents a physiologically more realistic model than the proof of principle in an in vitro mono-chamber bench model presented here.…”

Section: Future Perspectivesmentioning

confidence: 99%

Technical Feasibility and Design of a Shape Memory Alloy Support Device to Increase Ejection Fraction in Patients with Heart Failure

Aarnink

Halfwerk

Saïd

et al. 2019

Cardiovasc Eng Tech

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Purpose Heart failure is increasingly prevalent in the elderly. Treatment of patients with heart failure aims at improving their clinical condition, quality of life, prevent hospital (re)admissions and reduce mortality. Unfortunately, only a select group of heart failure patients with reduced ejection fraction are eligible for Cardiac Resynchronization Therapy where 30–40% remain non-responders and need left ventricular support. The aim of this study is to investigate if a shape memory alloy (SMA) is able to increase the ejection fraction of a mono-chamber static heart model by 5%. Methods A pediatric ventilation balloon was used as a heart model (mono-chamber). Flexinol ® , a SMA, was placed around the heart model in multiple configurations and activated using pulse width modulation techniques to determine influence of diameter and configuration on volume displacement. Furthermore, pressure within the heart model was measured with a custom-made pressure sensor. Results SMA with a diameter of 0.38 mm, placed in a spiral shape and activated with a duty cycle of 80% and a frequency of 50/min gave the highest ejection fraction increase of 3.5%. Conclusions This study demonstrated the feasibility of volume displacement in a static heart model by activation of SMA-wires. Configuration, duty cycle, frequency, pulse intervals and diameter were identified as important factors affecting the activation of SMA-wires on volume displacement. Future research should include the use of parallel SMA-wires, prototype testing in dynamic or ex vivo bench models. Electronic supplementary material The online version of this article (10.1007/s13239-018-00399-7) contains supplementary material, which is available to authorized users.

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“…The global organization of myocardial fibers explains the twisting motion and functional efficiency of the heart throughout the cardiac cycle. According to the Torrent-Guasp model, discerned through gross dissections, the ventricle consists of a helically organized myocardial band [ 39 ]. This band contains oblique, overlaying myocardial sheets with fiber angles rotating up to 104° from the endocardium (inner) to epicardium (outer) layer in the left ventricle of humans [ 40 ].…”

Section: Cardiac Mechanostructurementioning

confidence: 99%

Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction

Dwyer

Coulombe

2021

Bioactive Materials

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The mechanical environment and anisotropic structure of the heart modulate cardiac function at the cellular, tissue and organ levels. During myocardial infarction (MI) and subsequent healing, however, this landscape changes significantly. In order to engineer cardiac biomaterials with the appropriate properties to enhance function after MI, the changes in the myocardium induced by MI must be clearly identified. In this review, we focus on the mechanical and structural properties of the healthy and infarcted myocardium in order to gain insight about the environment in which biomaterial-based cardiac therapies are expected to perform and the functional deficiencies caused by MI that the therapy must address. From this understanding, we discuss epicardial therapies for MI inspired by the mechanics and anisotropy of the heart focusing on passive devices, which feature a biomaterials approach, and active devices, which feature robotic and cellular components. Through this review, a detailed analysis is provided in order to inspire further development and translation of epicardial therapies for MI.

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The Helical Ventricular Myocardial Band of Torrent-Guasp

Cited by 30 publications

References 119 publications

Distinctive Left-Sided Distribution of Adrenergic-Derived Cells in the Adult Mouse Heart

Distinctive Left-Sided Distribution of Adrenergic-Derived Cells in the Adult Mouse Heart

Technical Feasibility and Design of a Shape Memory Alloy Support Device to Increase Ejection Fraction in Patients with Heart Failure

Cardiac mechanostructure: Using mechanics and anisotropy as inspiration for developing epicardial therapies in treating myocardial infarction

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