The Heart: Pressure-Propulsion Pump or Organ of Impedance?

Furst, Branko

doi:10.1053/j.jvca.2015.02.022

Cited by 17 publications

(16 citation statements)

References 70 publications

(26 reference statements)

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“…This implicated both peristaltic and impedance pumping mechanisms (Butcher et al 2007;Kozlovsky et al 2016). Better understanding of the biomechanics underlying blood flow has important clinical implications, for example, for surgery after aortic dissection or myocardial infarct (for review, see Furst 2015).…”

Section: Atrial Chamber Separationmentioning

confidence: 99%

The Chicken as a Model Organism to Study Heart Development

Wittig

Münsterberg

2019

Cold Spring Harb Perspect Biol

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Section: Atrial Chamber Separationmentioning

confidence: 99%

The Chicken as a Model Organism to Study Heart Development

Wittig

Münsterberg

2019

Cold Spring Harb Perspect Biol

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“…3). The phenomenon of circulation persisting at the organ and tissue level after the recordable LVMA supports the concept that blood possesses its own kinetic energy determined by the metabolic demands of the tissues and calls for a revision of the conventional, pressurepropulsion circulation model (Furst 2015, Alexander 2017, Forouhar et al 2006. Intravital microscopy of early embryonic circulations has confirmed that a low-pressure circulation already exists before the functional integrity of the heart (Forouhar et al 2006).…”

Section: Discussionmentioning

confidence: 81%

Novel Patterns of Left Ventricular Mechanical Activity During Experimental Cardiac Arrest in Pigs

Škulec¹,

Astapenko²,

Parizkova³

et al. 2018

Physiol Res

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We conducted an experimental study to evaluate the presence of coordinated left ventricular mechanical myocardial activity (LVMA) in two types of experimentally induced cardiac arrest: ventricular fibrillation (VF) and pulseless electrical activity (PEA). Twenty anesthetized domestic pigs were randomized 1:1 either to induction of VF or PEA. They were left in nonresuscitated cardiac arrest until the cessation of LVMA and microcirculation. Surface ECG, presence of LVMA by transthoracic echocardiography and sublingual microcirculation were recorded. One minute after induction of cardiac arrest, LVMA was identified in all experimental animals. In the PEA group, rate of LVMA was of 106±12/min. In the VF group, we identified two patterns of LVMA. Six animals exhibited contractions of high frequency (VFhigh group), four of low frequency (VFlow group) (334±12 vs. 125±32/min, p<0.001). A time from cardiac arrest induction to asystole (19.2±7.2 vs. 7.3±2.2 vs. 8.3±5.5 min, p=0.003), cessation of LVMA (11.3±5.6 vs. 4.4±0.4 vs. 7.4±2.9 min, p=0.027) and cessation of microcirculation (25.3±12.6 vs. 13.4±2.4 vs. 23.2±8.7 min, p=0.050) was significantly longer in VFlow group than in VFhigh and PEA group, respectively. Thus, LVMA is present in both VF and PEA type of induced cardiac arrest and moreover, VF may exhibit various patterns of LVMA.

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“…In this more holistic model, the diastolic filling, i.e., the flowrestraining function of the heart, is equally as important as the pressure generation and systolic ejection of blood. 197,[201][202][203] Further evidence in support of this anthroposophical view is recent research in embryonic cardiovascular physiology that documents vigorous circulation of blood prior to the development of functional heart values 204 (this and related findings are summarized in Chaps. 1-10 of Furst's monograph).…”

Section: The Heart and Circulationmentioning

confidence: 99%

Anthroposophic Medicine: A Short Monograph and Narrative Review—Foundations, Essential Characteristics, Scientific Basis, Safety, Effectiveness and Misconceptions

Bartelme

2020

Glob Adv Health Med

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Introduction Anthroposophic medicine is a form of integrative medicine that originated in Europe but is not well known in the US. It is comprehensive and heterogenous in scope and remains provocative and controversial in many academic circles. Assessment of the nature and potential contribution of anthroposophic medicine to whole person care and global health seems appropriate. Methods Because of the heterogenous and multifaceted character of anthroposophic medicine, a narrative review format was chosen. A Health Technology Assessment of anthroposophic medicine in 2006 was reviewed and used as a starting point. A Medline search from 2006 to July 2020 was performed using various search terms and restricted to English. Books, articles, reviews and websites were assessed for clinical relevance and interest to the general reader. Abstracts of German language articles were reviewed when available. Reference lists of articles and the author’s personal references were also consulted. Results The literature on anthroposophic medicine is vast, providing new ways of thinking, a holistic view of the world, and many integrating concepts useful in medicine. In the last ∼20 years there has been a growing research base and implementation of many anthroposophical concepts in the integrated care of patients. Books and articles relevant to describing the foundations, scientific status, safety, effectiveness and criticisms of anthroposophic medicine are discussed. Discussion An objective and comprehensive analysis of anthroposophic medicine finds it provocative, stimulating and potentially fruitful as an integrative system for whole person care, including under-recognized life processes and psychospiritual aspects of human beings. It has a legitimate, new type of scientific status as well as documented safety and effectiveness in some areas of its multimodal approach. Criticisms and controversies of anthroposophic medicine are often a result of lack of familiarity with its methods and approach and/or come from historically fixed ideas of what constitutes legitimate science.

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The Heart: Pressure-Propulsion Pump or Organ of Impedance?

Cited by 17 publications

References 70 publications

The Chicken as a Model Organism to Study Heart Development

The Chicken as a Model Organism to Study Heart Development

Novel Patterns of Left Ventricular Mechanical Activity During Experimental Cardiac Arrest in Pigs

Anthroposophic Medicine: A Short Monograph and Narrative Review—Foundations, Essential Characteristics, Scientific Basis, Safety, Effectiveness and Misconceptions

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