The Heart in Inflammatory Myopathies

Gelder, Howard Van; Charles‐Schoeman, Christina

doi:10.1016/j.rdc.2013.10.002

Cited by 29 publications

(21 citation statements)

References 25 publications

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“…Given the strong association between vascular events and myositis [20–22], we studied arterial and venous events as well as their traditional risk factors, including hypertension, diabetes and dyslipidemia, as potential correlates of musculoskeletal damage. Neither vascular events nor their traditional risk factors were shown to be associated with myositis.…”

Section: Discussionmentioning

confidence: 99%

Associated Variables of Myositis in Systemic Lupus Erythematosus: A Cross-Sectional Study

et al. 2017

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BackgroundThis study aimed to estimate the point prevalence of myositis and identify associated variables of myositis in systemic lupus erythematosus (SLE).Material/MethodsClinical date of patients hospitalized with lupus at the First Affiliated Hospital of Anhui Medical University and Anhui Provincial Hospital were collected. Patients were defined as having myositis if they reported the presence of persistent invalidating muscular weakness combined with increased levels of creatine phosphokinase (CPK) and abnormal electromyography (EMG).ResultsThe study sample comprised 1701 lupus patients, of which 44 had myositis. Patients with SLE-associated myositis are more likely to have skin rash, alopecia, pericarditis, vasculitis, anti-Sm, anti-RNP, anti-dsDNA, thrombocytopenia, leukopenia, low C3, low C4, high erythrocyte sedimentation rate (ESR), high D-dimer, and active disease. Multivariate logistic regression found positive associations between leukopenia, alopecia, and active disease with myositis. Negative associations between myositis with the use of corticosteroids or immunosuppressive drugs were revealed in univariate and multivariate analysis.ConclusionsThe point prevalence of myositis was 2.6% in SLE patients. The significant association of alopecia, leukopenia, and active disease with myositis suggests that organ damage, hematological abnormality, and high disease activity promote the progression of myositis in lupus patients.

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Section: Discussionmentioning

confidence: 99%

Associated Variables of Myositis in Systemic Lupus Erythematosus: A Cross-Sectional Study

et al. 2017

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“…Amongst the CTDs, cardiac involvement is most prevalent in SSc [106] and IIM, in which cardiac disease is the third to most frequent cause of death after lung disease and malignancies [107]. Subclinical disease is more frequent than clinically relevant cardiac disease.…”

Section: Cardiac Diseasementioning

confidence: 99%

Comorbidities in interstitial lung diseases

2017

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Fibrosing lung disorders include a large number of diseases with diverse behaviour. Patients can die because of the progression of their illness, remain stable or even improve after appropriate treatment has been instituted. Comorbidities, such as acute and chronic infection, gastro-oesophageal reflux, pulmonary hypertension, lung cancer, cardiovascular diseases, and obstructive sleep apnoea, can pre-exist or develop at any time during the course of the disease and, if unidentified and untreated, may impair quality of life, impact upon the respiratory status of the patients, and ultimately lead to disease progression and death. Therefore, early identification and accurate treatment of comorbidities is essential.

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“…described that subclinical cardiac abnormalities were significantly more often found in patients with newly diagnosed IIM compared with control subjects . In fact, electrocardiographic abnormalities and arrhythmias are the most common cardiac disorders described in these patients, although myocardial dysfunction, coronary heart disease and myocarditis (which is typically asymptomatic or mild, as in our patient) have also been previously reported . Interestingly, despite SRP‐associated NM being initially connected to an increased incidence of cardiac involvement, this issue is not currently confirmed and remains controversial .…”

Section: What Is the Diagnosis?mentioning

confidence: 57%

“…On the other hand, NM can be complicated by many extramuscular symptoms or diseases, such as dysphagia, interstitial lung disease or heart disorders. Although clinically evident heart disease associated with IIM is uncommon, the emerging evidence of subclinical cardiac disease and the fact that cardiovascular diseases (CVD) represents a major cause of death among these patients, suggests the prevalence of heart involvement in IIM may be underestimated and may reach 72% . In this sense, Diederichsen et al .…”

Section: What Is the Diagnosis?mentioning

confidence: 99%