The heart in chronic alcoholism: a noninvasive study

Askanas, A; Udoshi, Mallikarjun; Sadjadi, Seyed Alireza

doi:10.1016/0002-8703(80)90309-9

Cited by 98 publications

(34 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings are consistent with some prior studies using echocardiography. Askansas et al [6] and Mathews et al [8] also found increased LV mass in chronic alcoholics without overt evidence of organic heart disease, but no abnormalities in systolic function, as in this study. These results provide potential insight into the pathogenesis of ACM.…”

Section: Volumes Mass and Function Datasupporting

confidence: 86%

Magnetic Resonance Imaging for Assessing Ventricular Volume and Function in Alcoholic Cardiomyopathy

Soldo¹,

Norris²,

Gober³

et al. 1993

Am J Noninvas Cardiol

View full text Add to dashboard Cite

Alcoholic cardiomyopathy (ACM) is difficult to diagnose until clinical congestive heart failure (CHF) appears. Earlier recognition and treatment might halt progression to CHF. We used ECG-gated, fast-field echo, short-axis 1H magnetic resonance images (MRI) to evaluate left ventricular (LV) function in 4 normal subjects, 4 chronic alcoholic patients with CHF, and 4 chronic alcoholic patients. MRI images were analyzed to generate volume-versus-time curves. LV mass (LVM) and volume data were derived as follows: end-diastolic volume (EDV) and EDV index (EDVI) and end-systolic volume (ESV) and ESV index (ESVI); stroke volume (SV) and SV index (SVI), LVM and LVM index (LVMI) and ejection fraction (EF). In ACM patients, EDVI (121 ± 30 cm^3) and ESVI (90 ± 20 cm^3) were significantly increased (p < 0.001), and EF was significantly decreased (27 ± 9%) compared to normal patients (64 ± 6%; p < 0.001). In ACM and asymptomatic (ASX) patients, LVMI (64 ± 15, 72 + 9 g/m^2, respectively) was greater than in normals (48 ± 9 g/m^2; p < 0.01 and p < 0.001, respectively); this was the only parameter that differed in ASX versus normal subjects. MRI measurement of LV function and mass is an effective tool for documenting the clinical and subclinical effects of alcohol on the heart.

show abstract

Section: Volumes Mass and Function Datasupporting

confidence: 86%

Magnetic Resonance Imaging for Assessing Ventricular Volume and Function in Alcoholic Cardiomyopathy

Soldo¹,

Norris²,

Gober³

et al. 1993

Am J Noninvas Cardiol

View full text Add to dashboard Cite

show abstract

“…The alcoholics tend to have more myocardial hypertrophy, interstitial fibrosis, and electrical irritability [26, 27]. Although gross microscopic examination has not been able to distinguish chronic idiopathic DCM from the chronic DCM found in alcoholics [28], electron microscopy has shown that patients who have also been chronic alcoholics have swelling of the sarcoplasmic reticulum which is more severe and generalized rather than focal [29, 30].…”

Section: Genuine Alcoholic Cardiomyopathies: Symptomatic Typesmentioning

confidence: 99%

The Alcoholic Cardiomyopathies – Genuine and Pseudo

Constant

1999

Cardiology

View full text Add to dashboard Cite

Two types of genuine alcoholic cardiomyopathies can produce congestive heart failure, an acute fulminate hyperkinetic type with high cardiac output and a hypokinetic type with a low cardiac output, both of which respond to thiamine. When the chronic alcoholic develops a dilated cardiomyopathy with congestive heart failure without a history of significant malnutrition, then they do not respond to thiamine. This may be explained by a study in which mice given a myotropic virus plus alcohol developed more frequent and severe viral cardiomyopathies than those not fed alcohol. This suggests that a chronic dilated cardiomyopathy in an alcoholic may not be the direct result of the alcohol but secondary to a viral myocarditis. This suggests that the preferred terminology for a dilated cardiomyopathy in an alcoholic who does not respond to thiamine and good nutrition should simply be a dilated cardiomyopathy in an alcoholic. We should assume that the cardiomyopathy is possibly of viral etiology.

show abstract

“…Considering that the LVM decreased in our patients, the increase in myocardium compliance could have been a further cause for the improvement in left ventricular func tion [3,20], Our data suggest a reversibility of earlier stages of cardiac involvement when formerly chronic alcoholic individuals abstained from drinking for a long time. Experimental stud ies in animals are in accordance with our interpretation; the impairment of uptake and binding of calcium by the sarcoplasmic reticulum and the decrease in left ventricular diastolic compliance related to interstitial collagen accumulation diminish myocardial contractility [33,34], These changes reverse after some months of abstinence [33].…”

Section: Discussionmentioning

confidence: 56%

Improvement of Left Ventricular Function in Chronic Alcoholics following Abstinence from Ethanol

1989

View full text Add to dashboard Cite

Preclinical abnormalities of left ventricular function are frequently found in chronic alcoholics. In 12 chronic alcoholics without cardiomyopathy and in 12 healthy controls, systolic time intervals and echocardiograms were investigated before and after 12 months of abstinence from alcohol. In chronic alcoholics, an increase was found in the PEP/LVET ratio (0.31 ± 0.06; in controls 0.24 ± 0.05; t = 3.11; p < 0.005), the diastolic interventricular septal thickness (6.0 ± 2.0 mm/m²; in controls 4.1 ± 1.0; t = 2.95; p < 0.01), the left ventricular wall thickness (6.3 ± 1.0 mm/m²; in controls 4.9 ± 1.0; t = 3.43; p < 0.005) and the left ventricular diastolic dimension (29 ± 4 mm/m²; in controls 26 ± 3; t = 2.08;p < 0.05). The left ventricular mass (135 ± 33 g/m²; in controls 113 ± 40; t= 1.47) did not differ from the controls. After 12 months of abstinence a significant decrease was found in the PEP/LVET ratio (0.26 ± 0.05, i.e. -16%; t = 3.59; p < 0.005), the diastolic interventricular septal thickness (4.7 ± 0.9 mm/m², i.e. -22%; t = 2.73; p < 0.02), the left ventricular posterior wall thickness (5.6 ± 1.0 mm/m², i.e. -11 %; t = 4.08; p < 0.001) and the left ventricular mass (109 ± 24 g/m², i.e. -21 %; t = 6.53; p < 0.001). The left ventricular diastolic dimension (27 ± 2 mm/m², i.e. -7%; t = 1.3) did not change. In conclusion, in chronic alcoholics, the abstinence from alcohol can be followed by an improvement of left ventricular function.

show abstract

The heart in chronic alcoholism: a noninvasive study

Cited by 98 publications

References 13 publications

Magnetic Resonance Imaging for Assessing Ventricular Volume and Function in Alcoholic Cardiomyopathy

Magnetic Resonance Imaging for Assessing Ventricular Volume and Function in Alcoholic Cardiomyopathy

The Alcoholic Cardiomyopathies – Genuine and Pseudo

Improvement of Left Ventricular Function in Chronic Alcoholics following Abstinence from Ethanol

Contact Info

Product

Resources

About