The Heart and Great Vessels

Onwuka, Ekene; King, Nakesha; Heuer, Eric; Breuer, Christopher K.

doi:10.1101/cshperspect.a031922

Cited by 10 publications

(6 citation statements)

References 141 publications

(165 reference statements)

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“…Cardio-cerebrovascular disease, mainly including cardiovascular disease (CVD) and stroke, is the leading cause of mortality worldwide (1,2). In 2017, CVD and stroke led to 17.8 million and 6.2 million deaths globally, with an increase by 21.1% and 16.6% from 2007 to 2017, respectively (3).…”

Section: Introductionmentioning

confidence: 99%

The association of outdoor temperature with blood pressure, and its influence on future cardio-cerebrovascular disease risk in cold areas

Yu¹,

Jin

Wang³

et al. 2020

Journal of Hypertension

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Objectives To explore whether lower outdoor temperature increases cardio-cerebrovascular disease risk through regulating blood pressure and whether indoor heating in winter is beneficial to prevent cardio-cerebrovascular disease in cold areas. MethodsWe analyzed the data of 38589 participants in Harbin from the China Kadoorie Biobank (CKB) during 2004-2008, with an average of 7.14-year follow-up.Linear regression analysis was performed to estimate the relationship between outdoor temperature and blood pressure. Cox regression analysis and Logistic regression analysis were used to analyze the association of blood pressure with cardio-cerebrovascular events risk. Mediation analysis was performed to explore the role of blood pressure in the association between outdoor pressure and cardio-cerebrovascular events risk. ResultsThere was an increase of 6.7 mmHg in SBP and 2.1 mmHg in DBP for each 10℃ decrease in outdoor temperature when outdoor temperature was higher than 5℃.There was an inverse association between outdoor temperature and cardio-cerebrovascular events morbidity. The increases in blood pressure and cardio-cerebrovascular events morbidity were attenuated in months when central heating was fully provided. Participants with hypertension have higher risks of

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Section: Introductionmentioning

confidence: 99%

The association of outdoor temperature with blood pressure, and its influence on future cardio-cerebrovascular disease risk in cold areas

Yu¹,

Jin

Wang³

et al. 2020

Journal of Hypertension

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“…The arterial supply of the human heart is provided by the left and right coronary arteries. However, cases of the presence of only one coronary artery originating from the right (1,2) or left aortic sinus (3,4) have been described, which may be associated with congestive heart failure, myocardial infarction, or sudden cardiac death (5).…”

Section: Introductionmentioning

confidence: 99%

“…In some cases, the existence of two excessive arteries (third and fourth) has been reported, which originate independently from the right aortic sinus (1,13,14).…”

Section: Introductionmentioning

confidence: 99%

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Morphological analysis and clinical significance of the opening of the third coronary artery

Lujinovic

Dervišević

Ćosović

et al. 2022

JHSCI

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Introduction: The human heart is in most cases vascularized by two coronary arteries, the right coronary artery (RCA) and the left coronary artery. The supernumerary coronary artery, which arises independently from the right aortic sinus and passes through sub-epicardial adipose tissue of the pulmonary conus and anterior side of the right ventricle is called the third coronary artery (TCA). Methods: This study consisted of 28 formalin-fixed adult human cadaveric hearts. The presence of the TCA was determined. The position of the orifice of the right and excess arteries in relation to the sinotubular junction was determined, and then also the position of the orifice of the excess arteries “on the o’clock level” in relation to the orifice of the RCA. The radius of these orifices and their distance from the orifice of the RCA were measured. The angle between the aorta and TCA, as well as RCA and conus branch, was measured. Results: A total 11 of specimens had supernumerary arteries. A supernumerary artery was found in two hearts. The angle formed by the aorta with the TCA was 60.09 ± 17.57, while the angle between the aorta and the conus branch had an average value of 89.88 ± 15.92. The orifices of all supernumerary arteries were located below the level of the sinotubular junction. The average diameter of the TCA was 1.49 mm ± 0.41. The average distance between the TCA orifice and the RCA orifice was 2.21 mm ± 1.03. In 45.45% cases, the orifice of TCA was located at the 10 o’clock level. Conclusion: The present study highlights the presence of the TCA. It may constitute a significant collateral circulation contributing to apical and septal perfusion. Interpretation of signs and symptoms of coronary occlusion should therefore include possible contribution of this vascular channel.

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“…This structural integrity is usually accomplished via a strong, but non-resorbable, outer layer, most often formed from expanded Polytetrafluoroethylene (ePTFE, i.e., Gore-Tex ® ) and polyethylene terephthalate (PET, or Dacron ® ) and polyurethane (PU) [5,6]. These grafts do not have growth capacity [4,7]. Thus, the ideal tissue engineering vascular grafts (TEVG) would be fully biodegradable, thereby obviating the need for risky serial reoperation to upsize the graft in response to somatic overgrowth [2].…”

Section: Introductionmentioning

confidence: 99%

Influence of Electrical Field Collector Positioning and Motion Scheme on Electrospun Bifurcated Vascular Graft Membranes

et al. 2019

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Currently, electrospinning membranes for vascular graft applications has been limited, due to random fiber alignment, to use in mandrel-spun, straight tubular shapes. However, straight, circular tubes with constant diameters are rare in the body. This study presents a method to fabricate curved, non-circular, and bifurcated vascular grafts based on electrospinning. In order to create a system capable of electrospinning membranes to meet specific patient needs, this study focused on characterizing the influence of fiber source, electrical field collector position (inside vs. outside the mandrel), and the motion scheme of the mandrel (rotation vs. rotation and tilting) on the vascular graft membrane morphology and mechanical properties. Given the extensive use of poly(ε-caprolactone) (PCL) in tubular vascular graft membranes, the same material was used here to facilitate a comparison. Our results showed that the best morphology was obtained using orthogonal sources and collector positioning, and a well-timed rotation and tilting motion scheme. In terms of mechanical properties, our bifurcated vascular graft membranes showed burst pressure comparable to that of tubular vascular graft membranes previously reported, with values up to 5126 mmHg. However, the suture retention strength shown by the bifurcated vascular graft membranes was less than desired, not clinically viable values. Process improvements are being contemplated to introduce these devices into the clinical range.

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The Heart and Great Vessels

Cited by 10 publications

References 141 publications

The association of outdoor temperature with blood pressure, and its influence on future cardio-cerebrovascular disease risk in cold areas

The association of outdoor temperature with blood pressure, and its influence on future cardio-cerebrovascular disease risk in cold areas

Morphological analysis and clinical significance of the opening of the third coronary artery

Influence of Electrical Field Collector Positioning and Motion Scheme on Electrospun Bifurcated Vascular Graft Membranes

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