The heart after idarubicin overdose. Cardiac death in a patient with acute promyelocitic leukaemia

Paolo, Marco Di; Aimo, Alberto; Barison, Andrea; Aquaro, Giovanni Donato; Roas, Laura; Emdin, M.

doi:10.1016/j.ijcard.2015.11.112

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…A whole-body standard autopsy was performed and the heart was explanted in an en bloc removal, according to the current guidelines for autopsy investigation of sudden death [ 12 ]. The heart was then excised and fixed in a formalin solution (10% neutral buffer, 4% formaldehyde) and maintained in ambient temperature [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

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Post-Mortem Cardiac Magnetic Resonance in Explanted Heart of Patients with Sudden Death

Aquaro

Guidi

Emdin

et al. 2022

IJERPH

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Background: We sought to evaluate the diagnostic accuracy of post-mortem cardiac magnetic resonance (PMCMR) of explanted hearts to detect the cardiac causes of sudden death. Methods: PMCMR was performed in formalin-fixed explanted hearts of 115 cases of sudden death. Histological sampling of myocardium was performed using two different approaches: (1) guideline-based sampling; (2) guideline-based plus PMCMR-driven sampling. Results: Forensic diagnosis of cardiac cause of death was ascertained in 72 (63%) patients. When the guideline-driven histological sampling was used, the PMCMR interpretation matched with final forensic diagnosis in 93 out of 115 cases (81%) with sensitivity of 88% (79–95%), specificity of 65% (47–80%), PPV of 84% (78–90%), NPV of 73% (58–84%), accuracy of 81% (72–88%), and AUC of 0.77 (0.68–0.84). When a PMCMR-driven approach was added to the guideline-based one, the matching increased to 102 (89%) cases with a PMCMR sensitivity of 89% (80–94%), a specificity of 86% (67–96%), PPV of 95% (89–98%), NPV of 73% (59–83%), accuracy of 89% (81–93%), and AUC of 0.88 (0.80–0.93). Conclusions: PMCMR has high accuracy to identify the cardiac cause of sudden death and may be considered a valid auxilium for forensic diagnosis. PMCMR could improve histological diagnosis in conditions with focal myocardial involvement or demonstrating signs of myocardial ischemia.

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Section: Methodsmentioning

confidence: 99%

“…The potentiality of PMCMR was demonstrated in studies evaluating individual cardiac disease such as myocardial infarction, acute ischemia, cardiomyopathies or myocardial toxic damage [ 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Post-Mortem Cardiac Magnetic Resonance in Explanted Heart of Patients with Sudden Death

Aquaro

Guidi

Emdin

et al. 2022

IJERPH

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Postmortem cardiac magnetic resonance in sudden cardiac death

et al. 2018

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Postmortem imaging is increasingly used in forensic practice as good complementary tool to conventional autopsy investigations. Over the last decade, postmortem cardiac magnetic resonance (PMCMR) imaging was introduced in forensic investigations of natural deaths related to cardiovascular diseases, which represent the most common causes of death in developed countries. Postmortem CMR application has yielded interesting results in ischemic myocardium injury investigations and in visualizing other pathological findings in the heart. This review presents the actual state of postmortem imaging for cardiovascular pathologies in cases of sudden cardiac death (SCD), taking into consideration both the advantages and limitations of PMCMR application.

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Idarubicin overdose

2016

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The heart after idarubicin overdose. Cardiac death in a patient with acute promyelocitic leukaemia

Cited by 3 publications

References 7 publications

Post-Mortem Cardiac Magnetic Resonance in Explanted Heart of Patients with Sudden Death

Post-Mortem Cardiac Magnetic Resonance in Explanted Heart of Patients with Sudden Death

Postmortem cardiac magnetic resonance in sudden cardiac death

Idarubicin overdose

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