The healthcare burden of disease progression in medicare patients with functional mitral regurgitation

McCullough, Peter A.; Mehta, Hirsch; Cork, David P.; Barker, Colin M.; Gunnarsson, Candace; Mollenkopf, Sarah; Houten, Joanna Van; Verta, Patrick

doi:10.1080/13696998.2019.1621325

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…Most patients with VHD are only diagnosed after developing complications, such as heart failure, which has a poor disease prognosis because VHD has a protracted asymptomatic period. [3] Additionally, the cost of medical care for patients increases with the severity of VHD; [4] therefore, a timely diagnosis is key to improving patient outcomes and reducing healthcare costs.…”

Section: Introductionmentioning

confidence: 99%

Automated valvular heart disease detection using heart sound with a deep learning algorithm

Jiang,

Song,

Yan

et al. 2024

IJC Heart & Vasculature

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Section: Introductionmentioning

confidence: 99%

Automated valvular heart disease detection using heart sound with a deep learning algorithm

Jiang,

Song,

Yan

et al. 2024

IJC Heart & Vasculature

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Effects of Sacubitril/Valsartan on Survival in Patients with Heart Failure and Significant Valvular Heart Disease

Lin,

Chao,

Chuang

et al. 2024

Clin Pharma and Therapeutics

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Although the benefits of sacubitril/valsartan in heart failure with reduced ejection fraction (HFrEF) are well established, patients with hemodynamically significant mitral regurgitation (MR) were excluded from pivotal trials. We aimed to assess the effects of sacubitril/valsartan on survival in patients with HFrEF and concomitant significant MR. All patients from a single center who underwent echocardiography between June 2008 and December 2020, with a left ventricular ejection fraction (LVEF) of less than 40% and hemodynamically significant MR were recruited. Patients were categorized according to drug use and year of the index echocardiogram into the angiotensin receptor/neprilysin inhibitor (ARNI), non‐ARNI before 2017, and non‐ARNI after 2017 groups. Patients in the ARNI and non‐ARNI after 2017 groups were compared directly, whereas patients in the non‐ARNI before 2017 group were matched to the ARNI group in a 3:1 ratio. The outcome of interest was all‐cause mortality. Death was compared between the groups using univariate and multivariate Cox proportional hazard models. After exclusion by criteria and matching, there remained 610 patients in the ARNI group, 434 in the non‐ARNI after 2017 group, and 1,722 in the non‐ARNI before 2017 group. During follow‐up, all‐cause mortality was significantly lower in the ARNI group compared with both non‐ARNI after 2017 and non‐ARNI before 2017 groups. Multivariate analysis of both pairs of comparison between groups found the use of ARNI to be significantly associated with increased survival. In patients with HFrEF and concomitant significant MR, treatment with sacubitril/valsartan was associated with lower risks of all‐cause death.

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Cost-effectiveness analysis of mitral valve repair with the MitraClip delivery system for patients with mitral regurgitation: a systematic review

et al. 2020

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The healthcare burden of disease progression in medicare patients with functional mitral regurgitation

Cited by 4 publications

References 23 publications

Automated valvular heart disease detection using heart sound with a deep learning algorithm

Automated valvular heart disease detection using heart sound with a deep learning algorithm

Effects of Sacubitril/Valsartan on Survival in Patients with Heart Failure and Significant Valvular Heart Disease

Cost-effectiveness analysis of mitral valve repair with the MitraClip delivery system for patients with mitral regurgitation: a systematic review

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