The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds

Parkinson, Lisa; Cicerale, Sara

doi:10.3390/molecules21121734

Cited by 156 publications

(129 citation statements)

References 81 publications

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“…Phenolic compounds in VOO were shown to improve endothelial dysfunction and reduce oxidative stress plasma parameters, both playing a key role in the development of atherosclerosis [131,132]. Moreover, VOO phenolic compounds could counteract inflammation, which is an important trigger in the development of atherosclerosis though the expression of adhesion molecules.…”

Section: Associated Complications: Oxidative Stress Inflammationmentioning

confidence: 99%

Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders

2017

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Virgin olive oil (VOO) constitutes the main source of fat in the Mediterranean diet. VOO is rich in oleic acid, displaying health-promoting properties, but also contains minor bioactive components, especially phenolic compounds. Hydroxytyrosol (HT), the main polyphenol of olive oil, has been reported to be the most bioactive component. This review aims to compile the results of clinical, animal and cell culture studies evaluating the effects of HT on the features of Metabolic Syndrome (MetS) (body weight/adiposity, dyslipidemia, hypertension, and hyperglycemia/insulin resistance) and associated complications (oxidative stress and inflammation). HT was able to improve the lipid profile, glycaemia, and insulin sensitivity, and counteract oxidative and inflammatory processes. Experimental studies identified multiple molecular targets for HT conferring its beneficial effect on health in spite of its low bioavailability. However, rodent experiments and clinical trials with pure HT at biologically relevant concentrations are still lacking. Moreover, the roles of intestine and its gut microbiota have not been elucidated.

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Section: Associated Complications: Oxidative Stress Inflammationmentioning

confidence: 99%

Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders

2017

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“…Oleacein (2), monoaldehydic form of oleuropein aglycone (5), and their deuterated derivatives (2-d and 5-d) used as surrogates in UHPLC-QTOF-MS, were supplied by Vado Olivo S.A. (Jaén, Spain). The NMR spectra for the four compounds are shown in Supporting Information Figures S1-S6.…”

Section: Chemicals and Reagentsmentioning

confidence: 99%

“…Nevertheless, it is possible to resolve these limitations by applying a low flow of the drying gas, high voltage of the capillary and sometimes, using post-column addition of a polar solvent [33,34]. In this work, we have focused our attention on the analysis of oleacein (2) and the combination of oleuropein aglycone isomers (5)(6) [35] in olive oil using 2-d and 5-d as deuterated surrogates. It is noteworthy that many interesting biological properties have been attributed to these compounds, such as antioxidative, hypotensive, anti-inflammatory, and anticancer [36,37].…”

Section: Introductionmentioning

confidence: 99%

Quantification of oleacein and oleuropein aglycone in olive oil using deuterated surrogates by normal‐phase ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Luque-Muñoz

Tapia

Haı̈dour

et al. 2018

J of Separation Science

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An analytical method for the analysis of relevant secoiridoid‐based components in olive oil, oleacein and oleuropein aglycone, is described using for the first time deuterated surrogates. 0.2 g of sample was necessary to perform the analysis using liquid‐liquid extraction and ultrasound‐assisted extraction with a mixture of methanol/water (4:1, v/v). To avoid the formation of by‐products, normal‐phase ultra high performance liquid chromatography was chosen for the chromatographic separation. The selected mobile phase was a gradient mixture of tetrahydrofurane and hexane, and an ACE Excel 3 CN‐ES column as stationary phase. The detection and quantification was performed with a SYNAPT G2‐Si mass spectrometer. The calibration curves for oleacein and oleuropein aglycone were linear and quadratic, respectively. The validation was done at three levels of concentration. Relative errors from 0.1 to 10.5% and relative standard deviations lower than 9% were obtained. The method was applied to study different samples of olive oil.

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“…19 Not all phenolics are present in every EVOO and considerable variation has been noted in the concentration of such phenolic compounds (50 to 1000 mg kg −1 ). 5,20,21 The EVOO phenolic content is determined by several factors such as olive variety (cultivar), growing area, fruit ripening, cultivation techniques, processing and storage conditions. [22][23][24]…”

Section: Introductionmentioning

confidence: 99%

“…The oil produced from this first press is known as EVOO; it is of the highest quality and it also contains the highest levels of beneficial constituents. 5,6 The olive oil chemical composition consists of major components (triacylglycerol) that represent about 98-99% of the total oil weight, mainly oleic acid (MUFA) much higher (55-83%) than that of the…”

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confidence: 99%

Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds

2018

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Dietary habits have been strongly linked to the maintenance of intestinal epithelium homeostasis, whose alteration may contribute to the pathogenesis of inflammatory diseases and cancer. Polyphenols are among those dietary components suggested to be beneficial for gut health. Within a balanced Mediterranean type diet, a good portion of ingested polyphenols comes from olives and extra virgin olive oil (EVOO). Most of them reach the intestine, where they may be directly absorbed or metabolized under absorption. Others undergo an extensive gastrointestinal biotransformation, producing various metabolites that retain the potential beneficial effect of the parent compounds, or exert a more efficient biological action themselves. Ingested EVOO polyphenols (EVOOP) and their metabolites will be particularly concentrated in the intestinal lumen, where they might exert a significant local action. In this review we summarize the few studies that investigated the effect of EVOOP at the intestinal level, focusing on the possible mechanism of action in relation to their interaction with the microbiota, and their ability to potentially modulate the oxidative status of the intestinal epithelial layer, inflammation and immune response.

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The Health Benefiting Mechanisms of Virgin Olive Oil Phenolic Compounds

Cited by 156 publications

References 81 publications

Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders

Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related Disorders

Quantification of oleacein and oleuropein aglycone in olive oil using deuterated surrogates by normal‐phase ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry

Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds

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