The Hannover experience: Surgical treatment of tongue cancer - A clinical retrospective evaluation over a 30 years period

Kokemueller, Horst; Rana, Majeed; Rublack, Jennifer; Eckardt, A.; Tavassol, Frank; Schumann, Paul; Lindhorst, Daniel; Ruecker, Martin; Gellrich, Nils‐Claudius

doi:10.1186/1758-3284-3-27

Cited by 31 publications

(37 citation statements)

References 43 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Outcome results and comparison with the non-IMRT literature of patients treated for recurrent OCC after initial surgery only are shown in Table 4[8-11]. …”

Section: Resultsmentioning

confidence: 99%

Follow up after IMRT in oral cavity cancer: update

et al. 2012

View full text Add to dashboard Cite

PurposeExcept for early stages (T1/2 N0), the prognosis for patients with oral cavity cancer (OCC) is known to be worse than for those with pharyngeal carcinoma. While definitive intensity modulated radiation therapy (IMRT)-chemotherapy affords loco-regional control rates (LRC) of approximately 80% in advanced pharyngeal cancer, corresponding rates are reported to be much lower for OCC. The aim of this work was to evaluate loco-regional disease control and overall survival (OAS) in a relatively large OCC patient cohort treated in the IMRT era.Methods and materialsBetween October 2002 and June 2011, 160 OCC patients were treated with curative intention IMRT at our department. 122 patients (76%) were referred with primary disease and 38 patients (24%) with a recurrent OCC at least 3 months after surgery alone. Definitive IMRT was performed in 44/160 patients (28%), whilst 116 patients underwent previous surgery. Simultaneous systemic therapy was administered in 72%.ResultsPatients with postoperative IMRT (+/−systemic therapy) with R0-1 status (n = 99) reached significantly higher LRC/OAS rates than patients following IMRT for macroscopic disease (n = 61), with 84%/80% versus 38%/33% at 3 years, respectively (p < 0.0001). This was found in patients treated for initial, as well as recurrent, disease. Less than 2% persisting grade 3/4 late effects were observed.ConclusionsIMRT for R0-1 situations translated into a highly significant superior LRC and OAS compared to the IMRT cohort treated for macroscopic disease. Treatment was well tolerated.

show abstract

“…Outcome results and comparison with the non-IMRT literature of patients treated for recurrent OCC after initial surgery only are shown in Table 4[8-11]. …”

Section: Resultsmentioning

confidence: 99%

Follow up after IMRT in oral cavity cancer: update

et al. 2012

View full text Add to dashboard Cite

show abstract

“…A study in Hannover found that there is an increase of fiveyear survival which is 54.5% on patients who received surgery, compared to 13.7% without the surgery. This is possibly caused by 83.5% patients had tumor size T1 and T2 (Kokemueller et al, 2011). At DNCH, surgery therapy was done to 45.6% patients because more than half of the patients were already in stage 3 and 4 that were non-operable.…”

Section: Discussionmentioning

confidence: 99%

Profile and Survival of Tongue Cancer Patients in "Dharmais" Cancer Hospital, Jakarta

Sutandyo

Ramli

Sari

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

The therapies applied were surgery (45.6%), radiation (63.6%) and chemotherapy (57.6%). The survival rate after one year is 60.6% and after two years was 12.1%. In addition, median survival of tongue cancer patients was 20 months (95% confidence interval 9.07-30.9). The significant factor affecting survival was size of tumor with a hazard ratio of 3.18 (95% CI, 1.02-9.93; p 0.046) for largest versus smallest categories. Conclusions: In each year, the number of tongue cancer incidents in Indonesia is increasing. The age of tongue cancer patients in Indonesia is younger compared to other countries. Moreover, the survival rates are not high.

show abstract

“…Despite the tremendous improvements in surgery, radiotherapy and chemotherapy over the last decade, the prognosis for patients with tongue squamous cell carcinoma (TSCC) has remained relatively unchanged for the past 3 decades[1]. This is because patients continue to succumb to metastatic disease at regional and distant sites.…”

Section: Introductionmentioning

confidence: 99%

Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling

Su²,

Cai³

et al. 2012

Free Radical Biology and Medicine

View full text Add to dashboard Cite

Our previous studies had revealed that the dysregulation of manganese superoxide dismutase (SOD2) expression was a frequent event in tongue squamous cell carcinoma (TSCC) and may be associated with enhanced metastatic potential. To further evaluate the mechanism of SOD2-mediated metastasis in TSCC, TSCC cell lines with different metastatic potential (i.e., the highly metastatic UM1 line and the UM2 line, which displays fewer metastases) were used. Compared to UM2 cells, UM1 cells exhibited significantly higher SOD2 activity and intracellular H2O2, higher protein levels of Snail, MMP-1 and pERK1/2, lower protein levels of E-cadtherin, and not difference of catalase activity. Upon knockdown of SOD2 by RNA interference, UM1 cells displayed significantly reduced migration and invasion abilities, reduced activities of SOD2, lower intracellular H2O2, decreased protein levels of Snail, MMP-1 and pERK1/2, and increased protein levels of E-cadtherin. Migration and invasion ability of UM2 and SOD2 shRNA-transfected UM1 cells were enhanced by H2O2 treatment and accompanied by increased protein levels of Snail, MMP-1 and pERK1/2, and decreased protein levels of E-cadtherin. Moreover the migration and invasion ability of UM1 cells were decreased after catalase treatment. Thus, we conclude that the SOD2-dependent production of H2O2 contributes to both the migration and invasion of TSCC via the Snail signaling pathway through increased Snail, MMP-1 and pERK1/2 protein levels, and the repression of the E-cadtherin protein.

show abstract

The Hannover experience: Surgical treatment of tongue cancer - A clinical retrospective evaluation over a 30 years period

Cited by 31 publications

References 43 publications

Follow up after IMRT in oral cavity cancer: update

Follow up after IMRT in oral cavity cancer: update

Profile and Survival of Tongue Cancer Patients in "Dharmais" Cancer Hospital, Jakarta

Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling

Contact Info

Product

Resources

About