The hallmarks of GSK-3 in morphogenesis and embryonic development metabolism in arthropods

Waltero, Camila Fernanda; Martins, Renato Parkinson; Calixto, Christiano; Fonseca, Rodrigo Nunes da; Abreu, Leonardo; Vaz, Itabajara da Silva; Logullo, Carlos

doi:10.1016/j.ibmb.2019.103307

Cited by 5 publications

(3 citation statements)

References 114 publications

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“…These multiple actions can be explained by its capacity to interact with some different substrates. Studies reported that about 100 proteins are phosphorylated by GSK-3 (Sutherland, 2011; Waltero et al ., 2020). In the tick R. microplus , only an isoform from the enzyme was identified, GSK-3 β , and the ovaries represent the main transcription site.…”

Section: Resultsmentioning

confidence: 99%

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Molecular targets for the development of new acaricides against Rhipicephalus microplus: a review

et al. 2022

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The cattle tick Rhipicephalus microplus is an ectoparasite with high economic importance to bovine culture, mainly in tropical and subtropical regions. The resistance of the tick from the commercial acaricides has hindered its control, thus motivating the search for new strategies. The purpose of this study was to perform a critical review about the main molecular targets of R. microplus that are useful for the discovery of new acaricides. Bibliographic search was conducted in the databases PubMed, ScienceDirect and CAB Direct, using the following descriptors: ‘Rhipicephalus microplus’, ‘Boophilus microplus’, ‘molecular targets’ and ‘action’, published between 2010 and 2021. Out of the 212 publications identified, 17 articles were selected for study inclusion. This review described 14 molecular targets and among these 4 are targets from commercial acaricides. Most of them are enzymes to catalyse important reactions to tick survival, related to energetic metabolism, mechanisms of biotransformation and neurotransmission. The data will be helpful in the development of new more effective and selective acaricides.

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Section: Resultsmentioning

confidence: 99%

“…In the tick R. microplus , only an isoform from the enzyme was identified, GSK-3 β , and the ovaries represent the main transcription site. GSK-3 β inhibition may lead to a reduction of oviposition and egg viability (Waltero et al ., 2020).…”

Section: Resultsmentioning

confidence: 99%

Molecular targets for the development of new acaricides against Rhipicephalus microplus: a review

et al. 2022

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“…Therefore, glycogen metabolism in insects is closely related to the formation and utilization of trehalose. Glycogen synthase kinase 3 (GSK3) is a serine–threonine kinase that acts as an important regulator of metabolism and development in diverse organisms [ 15 ]. Numerous studies have confirmed that GSK3 plays an essential role in regulating glucose metabolism [ 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Silencing of Glycogen Synthase Kinase 3 Significantly Inhibits Chitin and Fatty Acid Metabolism in Asian Citrus Psyllid, Diaphorina citri

Zhang

2022

IJMS

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Glycogen is a predominant carbohydrate reserve in various organisms, which provides energy for different life activities. Glycogen synthase kinase 3 (GSK3) is a central player that catalyzes glucose and converts it into glycogen. In this study, a GSK3 gene was identified from the D. citri genome database and named DcGSK3. A reverse transcription quantitative PCR (RT-qPCR) analysis showed that DcGSK3 was expressed at a high level in the head and egg. The silencing of DcGSK3 by RNA interference (RNAi) led to a loss-of-function phenotype. In addition, DcGSK3 knockdown decreased trehalase activity, glycogen, trehalose, glucose and free fatty acid content. Moreover, the expression levels of the genes associated with chitin and fatty acid synthesis were significantly downregulated after the silencing of DcGSK3. According to a comparative transcriptomics analysis, 991 differentially expressed genes (DEGs) were identified in dsDcGSK3 groups compared with dsGFP groups. A KEGG enrichment analysis suggested that these DEGs were primarily involved in carbon and fatty acid metabolism. The clustering analysis of DEGs further confirmed that chitin and fatty acid metabolism-related DEGs were upregulated at 24 h and were downregulated at 48 h. Our results suggest that DcGSK3 plays an important role in regulating the chitin and fatty acid metabolism of D. citri.

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PEPCK and glucose metabolism homeostasis in arthropods

Martins da Silva,

de Oliveira Daumas Filho,

Calixto

et al. 2023

Insect Biochemistry and Molecular Biology

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The hallmarks of GSK-3 in morphogenesis and embryonic development metabolism in arthropods

Cited by 5 publications

References 114 publications

Molecular targets for the development of new acaricides against Rhipicephalus microplus: a review

Molecular targets for the development of new acaricides against Rhipicephalus microplus: a review

Silencing of Glycogen Synthase Kinase 3 Significantly Inhibits Chitin and Fatty Acid Metabolism in Asian Citrus Psyllid, Diaphorina citri

PEPCK and glucose metabolism homeostasis in arthropods

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