The hair growth promoting effect of Sophora flavescens extract and its molecular regulation

Roh, Seok-Seon; Kim, Chang Deok; Hwang, Seong-Lok; Rang, Moon-Jeong; Yoon, Yeo-Kyeong

doi:10.1016/s0923-1811(02)00060-9

Cited by 73 publications

(60 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Determination of Hair Growth-Promoting Activity Hair growth-promoting activity of the RB-SCE was examined using the method reported by Roh et al 12) with some modifications. Briefly, mouse hair was removed from a 2 cm×3 cm dorsal area of mice by carefully shaving with an electric clipper.…”

Section: Oryza Sativa Bran Preparation and Materialsmentioning

confidence: 99%

“…3,11,12) Currently, natural extracts from several plants have been used for hair growth promotion, including Asiasari radix, 13) Eclipta alba, 14) essential oil of Chamaecyparis obtuse, 15) Zizyphus jujube, 16) and Sophora flavescens. 12) Rice (Oryza sativa) is one of the most important crops worldwide. It is a staple food for over half of the world's population with approximately 95% of rice produced in Asia and about 600 million tons of rice produced annually worldwide.…”

mentioning

confidence: 99%

See 1 more Smart Citation

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Choi

Jeon²,

Moon³

et al. 2014

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

The potential hair growth-promoting activity of rice bran supercritical CO 2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-promoting potential to a similar extent as 3% minoxidil, showing that the hair follicles were induced to be in the anagen stage. The numbers of the hair follicles were significantly increased. In addition, mRNA expression levels of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and keratinocyte growth factor (KGF) were also significantly increased and that of transforming growth factor-β (TGF-β) decreased in RB-SCE-treated groups. Among the major components of RB-SCE, linoleic acid and γ-oryzanol induced the formation of hair follicles according to examination of histological morphology and mRNA expression levels of cell growth factors. In conclusion, our results demonstrate that RB-SCE, particularly linoleic acid and γ-oryzanol, promotes hair growth and suggests RB-SCE can be applied as hair loss treatment. Key words rice bran supercritical CO 2 extract; hair growth-promoting activity; in vivoAlthough hair loss is not a mortal disorder, it has a great impact on a person's self-respect, mental health, and overall quality of life. Approximately 50-60 hairs are normally lost per day, which does not have a noticeable effect on appearance; however, excess loss (>100) results in baldness. Androgenetic alopecia is the most common type of hair loss, affecting millions of both men and women.1) There are many causes of hair loss in men and women, including diseases, nutritional deficiency, aging, hormone imbalance, and stress. Androgenetic alopecia may occur as early as the teenage years, but typically begin in the later decades of life. 2,3) Hair loss affects at least half of all men by the age of 50 and up to 70% of 70-year-old men. 4)

show abstract

Section: Oryza Sativa Bran Preparation and Materialsmentioning

confidence: 99%

mentioning

confidence: 99%

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Choi

Jeon²,

Moon³

et al. 2014

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…8 Root extract of Sophora flavescens has been reported to stimulate hair growth. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] In this study, formula II and III, each containing 0.5% and 1% of ethyl acetate fraction have faster hair growth than positive control (Figure 1). The mechanism of hair growth from the ethyl acetate fraction is still unclear, but the activity of hair growth resulting from the ethyl acetate fraction N. scutellarium leaves is suggested due to flavonoids.…”

Section: Hair Lengthmentioning

confidence: 86%

Hair Growth Promoting Activity of Nothopanax scutellarium Merr. Leaves

Rifkia¹,

Jufri²,

Mun’im³

2017

JYP

View full text Add to dashboard Cite

Objective: The aims of this study were to know the safety using Hen's eggs-chorioallantoic membrane (HET-CAM) test method and hair growth promoting activity of the ethyl acetate fraction of Nothopanax scutellarium leaves. Methods: Safety test was measured by scoring and categorizing irritation onHET-CAM. Meanwhile, activity test was conducted by applying the hair tonic of the ethylacetate fraction on the back of the rabbits, and the length of hair was measured in the 1 st , 2 nd and 3 rd week.In the 3 rd week, the hair growth was weighed and hair diameter also was measuredusing scanning electron microscope (SEM). Results:The result showed that 0.2 gram of ethyl acetate fraction of N.scutellarium leaves have mild irritation effect, whereas the formulation contained with 0.5% and 1% of fraction increased hair growth and hair diameter. Conclusion: The ethyl acetate fraction of N. scutellarium have mild irritan effect, and the hair tonic demonstrated hair growth promoting activity.

show abstract

“…The principal role of 5 α-reductase being conversion of testosterone to dihydrotestosterone (DHT). Inhibition of DHT formation serves as a strategy for the treatment of alopecia and prostate hyperplasia [1,2]. There are synthetic medicines, such as finasteride, dutasteride, alfatradiol but these compounds have been reported to have adverse effects which necessitate the interest in finding better 5 α-reductase inhibitors from natural resources.…”

Section: Introductionmentioning

confidence: 99%

Herbal Hair Gel Formulation having 5α-Reductase Inhibitory Activity and its Standardization by HPTLC

Chakraborty¹,

Bhattacharjee²

2016

J Anal Bioanal Tech

View full text Add to dashboard Cite

The present work has been undertaken with the aim to formulate hair growth gel formulation containing extracts of Hibiscus rosa sinensis flower 1%, Eclipta alba whole plant 1% and Solanum nigrum plant berries 0.5% which are preferably used in case of Alopecia, i.e., baldness pattern as an effective herbal therapy showing 5 α-reductase inhibitory activity. The formulated gel was evaluated for parameters such as pH which was found to be 6.68, viscosity 4731 cps, spreadability 11.05 (g-cm/sec) whereas consistent homogeneity was found with no skin irritation. Simultaneous quantification of bioactive markers was done by HPTLC. Quercetin, β-sitosterol and linoleic acid were selected as bioactive markers for quantification of Hibiscus rosa sinensis flower, Eclipta alba whole plant and Solanum nigrum plant berries extract respectively in the formulation. The aforementioned markers have 5 α-reductase inhibitory activity. β-sitosterol, quercetin and linoleic acid was found to be 0.1377, 0.120 and 0.379% w/w respectively in the formulated gel.

show abstract

The hair growth promoting effect of Sophora flavescens extract and its molecular regulation

Cited by 73 publications

References 26 publications

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Hair Growth Promoting Activity of Nothopanax scutellarium Merr. Leaves

Herbal Hair Gel Formulation having 5α-Reductase Inhibitory Activity and its Standardization by HPTLC

Contact Info

Product

Resources

About