The hair growth promoting effect of extract and its molecular regulation

Rho, Seok-Seon; Park, Su‐Jin; Hwang, Seong-Lok; Lee, Minho; Kim, Chang Deok; Lee, In-Ho; Chang, Sug-Youn; Rang, Moon-Jeong

doi:10.1016/j.jdermsci.2004.12.025

Cited by 93 publications

(80 citation statements)

References 36 publications

(43 reference statements)

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“…Genetic factors, cytokine imbalance, and oxidative stress can cause abnormal hair follicle cycling and subsequent hair loss (Rho et al, 2005;Aron et al, 2013). Many cytokines and receptors are involved in the cell cycle of human follicle dermal papilla cells, including the vascular endothelial cell growth factor (VEGF) (Shin et al, 2014), vascular endothelial cell growth factor receptor (VEGFR) (Li et al, 2012), fibroblast growth factor (FGF) (Rho et al, 2005), insulin-like growth factor (IGF) (Panchaprateep and Asawanonda, 2014), epidermal growth factor (EGF) (Bressan et al, 2014), keratinocyte growth factor (KGF) (Gopu et al, 2015), and transforming growth factor (TGF) (Kang et al, 2013;Shin et al, 2014). Some hair regeneration has been achieved by molecular effect and growth factors (Danilenko et al, 1996) and follicle dermal stem cells (Rahmani et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Enhanced VEGF Expression in Hair Follicle Dermal Papilla Cells by Centella asiatica Linn.

Saansoomchai¹,

Limmongkon²,

Surangkul³

et al. 2018

CMUJNS

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Centella asiatica Linn. (C. asiatica) extract has been shown to possess high antioxidant activity due to its phenols and flavonoids. This study tested the efficacy of 70%-ethanol (EtOH) crude extracts of C. asiatica and its fractions (H 2 O, EtOAc, CH 2 Cl 2 , and hexane) to modulate human follicle dermal papilla cells. In addition, we analyzed the extracts for major phytochemicals as well as free radical scavenging activity. Our results from ABTS and DPPH assays showed that the amounts of phenolic and flavonoid compounds in the extracts were both related to its free radical scavenging activity. While the EtOAc fraction of C. asiatica demonstrated the highest free radical scavenging activity, it was toxic to human follicle dermal papilla cells. The cell viability test was positive when cells were treated with EtOH crude extract and H 2 O fraction. VEGF gene expression, quantified by real-time PCR analysis of the EtOH crude extract, showed a significant level of induction, indicating that the growth promotion effect in human follicle dermal papilla cells was related to VEGF gene expression, which has a positive hair growth stimulating effect. The EtOH crude extract of C. asiatica may offer potential in hair growth promoting products.

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Section: Introductionmentioning

confidence: 99%

“…Some evidence has suggested that VEGF and VEGFR could induce the proliferation of human follicle dermal papilla cells through ERK activation (Li et al, 2012). TGF has been related to human follicle dermal papilla cell death involving free radicals (Soma et al, 2003;Rho et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Enhanced VEGF Expression in Hair Follicle Dermal Papilla Cells by Centella asiatica Linn.

Saansoomchai¹,

Limmongkon²,

Surangkul³

et al. 2018

CMUJNS

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“…In the past several years, there have been numerous attempts to develop new agents capable of preventing and/or treating pattern baldness. 3,11,12) Currently, natural extracts from several plants have been used for hair growth promotion, including Asiasari radix, 13) Eclipta alba, 14) essential oil of Chamaecyparis obtuse, 15) Zizyphus jujube, 16) and Sophora flavescens. 12) Rice (Oryza sativa) is one of the most important crops worldwide.…”

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confidence: 99%

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Choi

Jeon²,

Moon³

et al. 2014

Biological & Pharmaceutical Bulletin

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The potential hair growth-promoting activity of rice bran supercritical CO 2 extract (RB-SCE) and major components of RB-SCE, linoleic acid, policosanol, γ-oryzanol, and γ-tocotrienol, were evaluated with the histological morphology and mRNA expression levels of cell growth factors using real-time reverse transcriptase-polymerase chain reaction (PCR) in C57BL/6 mice. RB-SCE showed hair growth-promoting potential to a similar extent as 3% minoxidil, showing that the hair follicles were induced to be in the anagen stage. The numbers of the hair follicles were significantly increased. In addition, mRNA expression levels of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), and keratinocyte growth factor (KGF) were also significantly increased and that of transforming growth factor-β (TGF-β) decreased in RB-SCE-treated groups. Among the major components of RB-SCE, linoleic acid and γ-oryzanol induced the formation of hair follicles according to examination of histological morphology and mRNA expression levels of cell growth factors. In conclusion, our results demonstrate that RB-SCE, particularly linoleic acid and γ-oryzanol, promotes hair growth and suggests RB-SCE can be applied as hair loss treatment. Key words rice bran supercritical CO 2 extract; hair growth-promoting activity; in vivoAlthough hair loss is not a mortal disorder, it has a great impact on a person's self-respect, mental health, and overall quality of life. Approximately 50-60 hairs are normally lost per day, which does not have a noticeable effect on appearance; however, excess loss (>100) results in baldness. Androgenetic alopecia is the most common type of hair loss, affecting millions of both men and women.1) There are many causes of hair loss in men and women, including diseases, nutritional deficiency, aging, hormone imbalance, and stress. Androgenetic alopecia may occur as early as the teenage years, but typically begin in the later decades of life. 2,3) Hair loss affects at least half of all men by the age of 50 and up to 70% of 70-year-old men. 4)

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“…Several growth factors are reported to have important roles in hair growth. IGF-1, VEGF, keratinocyte growth factor (KGF), and HGF have stimulatory effects, whereas epidermal growth factor (EGF) and TGF-β have inhibitory effects on hair follicle growth (24). IGF-1 has important biological activities in various cell types, including hair follicles, such as promotion of growth and differentiation.…”

Section: Discussionmentioning

confidence: 99%

Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles

Hwang

Kim²,

Roh³

et al. 2011

Int J Mol Med

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Abstract. Hair regression and balding are distressing concerns for an increasing number of people due to changes in lifestyle and serious nutritional imbalances. Therapies for treatment of hair loss are needed. Among potential therapeutics, adenosine has been suggested as a potent regulator of hair growth. In this study, we investigated the effects of adenosine on hair follicles and dermal papilla (DP) cells, and the mechanism underlying the action of adenosine. Hair follicles are organs, including DP cells, that are responsible for the production of hair fibers by inducing and maintaining the hair growth phase (anagen). In a culture of DP cells in vitro, adenosine stimulated proliferation of DP cells by increasing thymidine uptake. Subsequently, adenosine activated and elongated the anagen phase by increasing the uptake of radiolabeled cysteine in an organ culture of mouse vibrissae hair follicles. We also confirmed that adenosine promoted the expression of several growth factors that are responsible for hair growth, including fibroblast growth factors (FGF)-7, FGF-2, insulin-like growth factor (IGF)-1, and vascular endothelial growth factor (VEGF) in a cDNA microarray with semi-quantitative RT-PCR. Transcriptional activation of β-catenin in DP cells was increased by adenosine in a luciferase assay. β-catenin is a co-activator of Wnt/β-catenin signaling that induces morphogenesis and differentiation of hair follicles and also acts to transactivate downstream signaling pathways, including the ERK pathway. Using Western blotting, we found that adenosine stimulated phosphorylation of ERK, CREB and AKT. These results suggest that adenosine stimulates growth of hair follicles by triggering the expression of growth factors and β-catenin, and by inducing their downstream target signaling pathways.

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The hair growth promoting effect of extract and its molecular regulation

Cited by 93 publications

References 36 publications

Enhanced VEGF Expression in Hair Follicle Dermal Papilla Cells by Centella asiatica Linn.

Enhanced VEGF Expression in Hair Follicle Dermal Papilla Cells by Centella asiatica Linn.

<i>In Vivo</i> Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid

Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles

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