The hagfish heart

Davison, William

doi:10.1201/b18935-10

Cited by 4 publications

(4 citation statements)

References 47 publications

(63 reference statements)

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“…The remarkable design of this discrete brain region has been overlooked, with tanycytes being a key component of this design. Sower 37 to suggest that the hagfish may have both a diffusional model of regulation of the pituitary and a "pre-median eminence" endowed with a modest portal circulation. This ancestral median eminence consists of neurosecretory axons and ependymal cells with a long process (ancestors of tanycytes?)…”

Section: Infund Ibul Ar Rece Ss Of the Third Ventriclementioning

confidence: 99%

“…90 In these species, the only cell types present in both neural lobe and median eminence are tanycytes whose processes traverse the whole gland to form a cuff on the blood capillaries (see section 5). The fine structure of these primitive tanycytes (including their content of lipid droplets), [36][37][38][39][40]90 and their response to certain experimental conditions, 38 suggest that they are a common ancestor of β-tanycytes and pituicytes.…”

Section: Pitu I C Y Te S: the Forg Ot Ten Partnermentioning

confidence: 99%

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Tanycytes: A rich morphological history to underpin future molecular and physiological investigations

Rodríguez

Guerra

Peruzzo

et al. 2019

J Neuroendocrinology

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Tanycytes are located at the base of the brain and retain characteristics from their developmental origins, such as radial glial cells, throughout their life span. With transport mechanisms and modulation of tight junction proteins, tanycytes form a bridge connecting the cerebrospinal fluid with the external limiting basement membrane. They also retain the powers of self‐renewal and can differentiate to generate neurones and glia. Similar to radial glia, they are a heterogeneous family with distinct phenotypes. Although the four subtypes so far distinguished display distinct characteristics, further research is likely to reveal new subtypes. In this review, we have re‐visited the work of the pioneers in the field, revealing forgotten work that is waiting to inspire new research with today's cutting‐edge technologies. We have conducted a systematic ultrastructural study of α‐tanycytes that resulted in a wealth of new information, generating numerous questions for future study. We also consider median eminence pituicytes, a closely‐related cell type to tanycytes, and attempt to relate pituicyte fine morphology to molecular and functional mechanism. Our rationale was that future research should be guided by a better understanding of the early pioneering work in the field, which may currently be overlooked when interpreting newer data or designing new investigations.

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Section: Infund Ibul Ar Rece Ss Of the Third Ventriclementioning

confidence: 99%

Section: Pitu I C Y Te S: the Forg Ot Ten Partnermentioning

confidence: 99%

Tanycytes: A rich morphological history to underpin future molecular and physiological investigations

Rodríguez

Guerra

Peruzzo

et al. 2019

J Neuroendocrinology

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“…In vertebrates, a symphony of physiological events is required to regulate sexual behavior and reproduction, and these mechanisms are driven by an interconnected biological system made up of the hypothalamus in the brain, the pituitary gland, and the gonads (testes/ovaries) [7,[35][36][37]. This hypothalamic-pituitary-gonadal (HPG) axis can be disrupted in multiple, complex ways [7,[38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Stress-mediated convergence of splicing landscapes in male and female rock doves

et al. 2020

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Background: The process of alternative splicing provides a unique mechanism by which eukaryotes are able to produce numerous protein products from the same gene. Heightened variability in the proteome has been thought to potentiate increased behavioral complexity and response flexibility to environmental stimuli, thus contributing to more refined traits on which natural and sexual selection can act. While it has been long known that various forms of environmental stress can negatively affect sexual behavior and reproduction, we know little of how stress can affect the alternative splicing associated with these events, and less still about how splicing may differ between sexes. Using the model of the rock dove (Columba livia), our team previously uncovered sexual dimorphism in the basal and stress-responsive gene transcription of a biological system necessary for facilitating sexual behavior and reproduction, the hypothalamic-pituitary-gonadal (HPG) axis. In this study, we delve further into understanding the mechanistic underpinnings of how changes in the environment can affect reproduction by testing the alternative splicing response of the HPG axis to an external stressor in both sexes. Results: This study reveals dramatic baseline differences in HPG alternative splicing between males and females. However, after subjecting subjects to a restraint stress paradigm, we found a significant reduction in these differences between the sexes. In both stress and control treatments, we identified a higher incidence of splicing activity in the pituitary in both sexes as compared to other tissues. Of these splicing events, the core exon event is the most abundant form of splicing and more frequently occurs in the coding regions of the gene. Overall, we observed less splicing activity in the 3'UTR (untranslated region) end of transcripts than the 5'UTR or coding regions. Conclusions: Our results provide vital new insight into sex-specific aspects of the stress response on the HPG axis at an unprecedented proximate level. Males and females uniquely respond to stress, yet exhibit splicing patterns suggesting a convergent, optimal splicing landscape for stress response. This information has the potential to inform evolutionary theory as well as the development of highly-specific drug targets for stressinduced reproductive dysfunction.

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“…In vertebrates, a symphony of physiological events is required to regulate sexual behavior and reproduction, and these mechanisms are driven by an interconnected biological system made up of the hypothalamus in the brain, the pituitary gland, and the gonads (testes/ovaries) (Sower, Freamat & Kavanaugh, 2009;Nozaki, 2013;MacManes et al, 2017;Calisi et al, 2018). This hypothalamic-pituitary-gonadal (HPG) axis can be disrupted in multiple, complex ways (Johnson et al, 1992;Toufexis et al, 2014;Geraghty & Kaufer, 2015;Calisi et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Stress-mediated convergence of splicing landscapes in male and female Rock Doves

Lang

MacManes

Calisi

et al. 2019

Preprint

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Background: The process of alternative splicing provides a unique mechanism by which eukaryotes are able to produce numerous protein products from the same gene. Heightened variability in the proteome has been thought to potentiate increased behavioral complexity and response flexibility to environmental stimuli, thus contributing to more refined traits on which natural and sexual selection can act. While it has been long known that various forms of environmental stress can negatively affect sexual behavior and reproduction, we know little of how stress can affect the alternative splicing associated with these events, and less still about how splicing may differ between sexes. Using the model of the rock dove (Columba livia), our team previously uncovered sexual dimorphism in the basal and stress-responsive gene transcription of a biological system necessary for facilitating sexual behavior and reproduction, the hypothlamic-pituitary-gonadal (HPG) axis. In this study, we delve further into understanding the mechanistic underpinnings of how changes in the environment can affect reproduction by testing the alternative splicing response of the HPG axis to an external stressor in both sexes.Results: This study reveals dramatic baseline differences in HPG alternative splicing between males and females. However, post submitting subjects to a restraint stress paradigm, we found a significant reduction in these differences between the sexes. In both stress and control treatments, we identified a higher incidence of splicing activity in the pituitary in both sexes as compared to other tissues. Of these splicing events, the core exon event is the most abundant form of splicing and more frequently occurs in the coding regions of the gene. Overall, we observed less splicing activity in the 3'UTR end of transcripts than the 5'UTR or coding regions. Conclusions:Our results provide vital new insight into sex-specific aspects of the stress response on the HPG axis at an unprecedented proximate level. Males and females uniquely respond to stress, yet exhibit splicing patterns suggesting a convergent, optimal splicing landscape for stress response. This information has the potential to inform evolutionary theory as well as the development of highly-specific drug targets for stress-induced reproductive dysfunction.

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The hagfish heart

Cited by 4 publications

References 47 publications

Tanycytes: A rich morphological history to underpin future molecular and physiological investigations

Tanycytes: A rich morphological history to underpin future molecular and physiological investigations

Stress-mediated convergence of splicing landscapes in male and female rock doves

Stress-mediated convergence of splicing landscapes in male and female Rock Doves

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