The haemodynamic response to hyperinsulinaemia in hypertensive subjects

Lind, Lars; Andersson, Per-Erik; Fugmann, Andreas; Hänni, Arvo; Reneland, Richard; Linde, Torbjörn; Lithell, Hans

doi:10.1038/sj.jhh.1000723

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Actions Of Insulin On Resistance Vessels In Skeletal Muscle1

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2003

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“…However, not all studies have shown increases in total flow with insulin 9, 10. Moreover, the increase in glucose uptake induced by insulin has been observed to generally precede in time the increases in total flow 1, 11. Beyond that, investigators reasoned that if glucose uptake has a significant flow‐dependent component, then augmenting flow during insulin exposure should further promote glucose uptake.…”

Section: Actions Of Insulin On Resistance Vessels In Skeletal Musclementioning

confidence: 99%

The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake

Clerk

Vincent

Lindner

et al. 2003

Diabetes Metabolism Res

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Whether a discrete vascular action of insulin in skeletal muscle integrally participates in insulin-mediated glucose disposal has been extensively examined but remains a contentious issue. Here, we review some of the data both supporting and questioning the role of insulin-mediated increases in limb blood flow in glucose metabolism. We advance the hypothesis that controversy has arisen, at least in part, from a failure to recognize that insulin exerts at least three separate actions on the peripheral vasculature, each with its own characteristic dose and time responsiveness. We summarize how, viewed in this manner, certain points of contention can be resolved. We also advance the hypothesis that an action on the precapillary arteriole may play the dominant role in mediating perfusion-dependent effects of insulin on glucose metabolism in muscle.

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